4-(6-HYDROXY-2-NAPHTHYL)-1,3-BENZENEDIOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H12O3
Molecular Weight	252.2647
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 4-(6-HYDROXY-2-NAPHTHYL)-1,3-BENZENEDIOL

Structure Search

SMILES

OC1=CC(O)=C(C=C1)C2=CC3=C(C=C2)C=C(O)C=C3

InChI

InChIKey=BXZJBSHLEZAMOP-UHFFFAOYSA-N

InChI=1S/C16H12O3/c17-13-4-3-10-7-12(2-1-11(10)8-13)15-6-5-14(18)9-16(15)19/h1-9,17-19H

HIDE SMILES / InChI

Molecular Formula	C16H12O3
Molecular Weight	252.2647
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Akt signaling pathway 1 Target ID: Akt signaling pathway Sources: https://www.ncbi.nlm.nih.gov/pubmed/27840966	Inhibitor 8504
Apoptosis 156 Target ID: map04210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27840966 \| https://www.ncbi.nlm.nih.gov/pubmed/24316714	Activator 1447

PubMed

Title	Date	PubMed
HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model.	2017-08	28656256
Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells.	2017-01	27840966
The resveratrol analog HS-1793 enhances radiosensitivity of mouse-derived breast cancer cells under hypoxic conditions.	2016-10	27498957
Interferon gamma induced by resveratrol analog, HS-1793, reverses the properties of tumor associated macrophages.	2014-10	25042796
In Vitro Genotoxicity Assessment of a Novel Resveratrol Analogue, HS-1793.	2014-09	25343016
Protective activity of a novel resveratrol analogue, HS-1793, against DNA damage in 137Cs-irradiated CHO-K1 cells.	2014-05	24403520
HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells.	2014-02	24316714
A novel resveratrol analogue, HS-1793, inhibits hypoxia-induced HIF-1α and VEGF expression, and migration in human prostate cancer cells.	2013-12	24100602
HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage.	2013-07-15	23735745
The novel resveratrol analogue HS-1793 induces apoptosis via the mitochondrial pathway in murine breast cancer cells.	2012-11	22940714
Resveratrol analog, HS-1793 enhance anti-tumor immunity by reducing the CD4+CD25+ regulatory T cells in FM3A tumor bearing mice.	2012-11	22884509
An analogue of resveratrol HS-1793 exhibits anticancer activity against MCF-7 cells via inhibition of mitochondrial biogenesis gene expression.	2012-10	23104437
Resveratrol analogue HS-1793 induces the modulation of tumor-derived T cells.	2012-04	22969934
A novel resveratrol derivative, HS1793, overcomes the resistance conferred by Bcl-2 in human leukemic U937 cells.	2009-04-15	19426672

Substance Class	Chemical Created by `admin` on `Wed Apr 02 13:33:51 GMT 2025` Edited by `admin` on `Wed Apr 02 13:33:51 GMT 2025`
Record UNII	5YWK2UV4R5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HS-1793

Preferred Name

English

4-(6-HYDROXY-2-NAPHTHYL)-1,3-BENZENEDIOL

Systematic Name

English

1,3-BENZENEDIOL, 4-(6-HYDROXY-2-NAPHTHALENYL)-

Systematic Name

English

4-(6-OXIDANYLNAPHTHALEN-2-YL)BENZENE-1,3-DIOL

Systematic Name

English

Code System Code Type Description

CAS

927885-00-5

Created by admin on Wed Apr 02 13:33:51 GMT 2025 , Edited by admin on Wed Apr 02 13:33:51 GMT 2025

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FDA UNII

5YWK2UV4R5

Created by admin on Wed Apr 02 13:33:51 GMT 2025 , Edited by admin on Wed Apr 02 13:33:51 GMT 2025

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PUBCHEM

16215105

Created by admin on Wed Apr 02 13:33:51 GMT 2025 , Edited by admin on Wed Apr 02 13:33:51 GMT 2025

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