U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 15:14:23 GMT 2025
Edited
by admin
on Wed Apr 02 15:14:23 GMT 2025
Protein Type BISPECIFIC ANTIBODY
Protein Sub Type IGG1|KAPPA
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
5Y27P3LNU6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Etakafusp Alfa
INN  
Official Name English
AB-248
Preferred Name English
humanized immunoglobulin G1-kappa anti-(human CD8) fused at the C-terminus of one heavy chain, via peptide linker <sup>449</sup> SGGGGSGGGGSGGGGS<sup>464</sup>, to a variant of human interleukin-2, glycoform alfa
Common Name English
Immunoglobulin G1 [236-alanine,237-alanine,239-alanine,356-cysteine,368-serine,370-alanine,409-valine,de-449-lysine], anti-(human CD8 antigen) (human-Mus musculus monoclonal AB248 ?1-chain) fusion protein with peptide linker ((SGGGG)3S) fusion protein wi
Common Name English
etakafusp alfa [INN]
Common Name English
AB248
Code English
gamma 1 heavy chain (1-448) [VH (Homo sapiens IGHV1-69*01 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.10] (31-35.50-66.99-108)) (1-119) -Homo sapiens IGHG1*03v (CH1 (120-217), hinge (218-232), CH2 L <sup>236</sup> >A, L <sup>237</sup> >A, G<sup>239</sup> >A (233-
Common Name English
Code System Code Type Description
CAS
2852680-28-3
Created by admin on Wed Apr 02 15:14:23 GMT 2025 , Edited by admin on Wed Apr 02 15:14:23 GMT 2025
PRIMARY
SMS_ID
300000054782
Created by admin on Wed Apr 02 15:14:23 GMT 2025 , Edited by admin on Wed Apr 02 15:14:23 GMT 2025
PRIMARY
FDA UNII
5Y27P3LNU6
Created by admin on Wed Apr 02 15:14:23 GMT 2025 , Edited by admin on Wed Apr 02 15:14:23 GMT 2025
PRIMARY
INN
12919
Created by admin on Wed Apr 02 15:14:23 GMT 2025 , Edited by admin on Wed Apr 02 15:14:23 GMT 2025
PRIMARY
NCI_THESAURUS
C192789
Created by admin on Wed Apr 02 15:14:23 GMT 2025 , Edited by admin on Wed Apr 02 15:14:23 GMT 2025
PRIMARY
From To
2_263 2_323
4_134 4_194
4_23 4_88
3_134 3_194
3_23 3_88
2_222 4_214
2_146 2_202
2_22 2_96
1_263 1_323
1_231 2_231
1_228 2_228
1_222 3_214
1_146 1_202
1_22 1_96
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_299
N 2_299
O 1_467
Related Record Type Details
Etakafusp Alfa
ACTIVE MOIETY
PRECLINICAL

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS Q PIDOLIC ACID SZB83O1W42
AMINO ACID REMOVAL [2_449] C-TERMINUS K LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966