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GIVOSIRAN SODIUM
5XE21E41RT
US Approved Rx (2019)
First approved in 2019
General
Record Details
Names
6
Identifiers
7
Subunits
2
Sugars
2
Linkages
2
Relationships
1
Active Moiety
1
Modifications
1
Characteristic Attributes
1
GIVOSIRAN SODIUM
5XE21E41RT
US Approved Rx (2019)
First approved in 2019
General
Approval Year
2019
334
Record Details
Substance Class
Nucleic Acid
Sequence Type
OLIGONUCLEOTIDE
Record UNII
5XE21E41RT
Record Status
Validated (UNII)
Record Version
27
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Names
6
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5
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100
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entries
Name
Type
Language
Name
Type
Language
GIVOSIRAN SODIUM
Common Name
English
GIVLAARI
Preferred Name
English
GIVOSIRAN SODIUM [MI]
Common Name
English
GIVOSIRAN SODIUM [ORANGE BOOK]
Common Name
English
Givosiran sodium [WHO-DD]
Common Name
English
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2
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Identifiers
7
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entries
Code System
Code
Type
Description
Code System
Code
Type
Description
MERCK INDEX
m12182
PRIMARY
FDA UNII
5XE21E41RT
PRIMARY
SMS_ID
100000183968
PRIMARY
DRUG BANK
DBSALT002906
PRIMARY
DAILYMED
5XE21E41RT
PRIMARY
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Subunits
2
Sugars
2
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Sugar
Site Range
Site Count
Sugar
Site Range
Site Count
2'-Fluoro-Ribose
1_2-1_4;1_6;1_8;1_10;1_12;1_14;1_16;1_18;1_20;2_7;2_9;2_11;2_13;2_15
16 / 45
2'-O-Methyl-Ribose
1_1;1_5;1_7;1_9;1_11;1_13;1_15;1_17;1_19;1_21-1_23;2_1-2_6;2_8;2_10;2_12;2_14;2_16-2_22
29 / 45
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Linkages
2
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Linkage
Site Range
Site Count
Linkage
Site Range
Site Count
Sodium Phosporothioate
1_2-1_3;1_22-1_23;2_4-2_5
6 / 43
1_4-1_21;2_4-2_22
37 / 43
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Relationships
1
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Related Record
Type
Details
Related Record
Type
Details
ROV204583W
Givosiran
PARENT -> SALT/SOLVATE
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Active Moiety
1
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Related Record
Type
Details
Related Record
Type
Details
ROV204583W
Givosiran
ACTIVE MOIETY
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Modifications
1
Structural Modifications
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entries
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
NUCLEOTIDE SUBSTITUTION
[2_22]
GIVOSIRAN SODIUM TRIGLYCAN-END GROUP
8142CN1H73
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Characteristic Attributes
1
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entries
Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
MOL_WEIGHT:NUMBER(CALCULATED)
CHEMICAL
NUMBER 17245 Da (average)
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