GIVOSIRAN SODIUM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 10:18:42 UTC 2023` Edited by `admin` on `Sat Dec 16 10:18:42 UTC 2023`
Nucleic Acid Subtype
Sequence Type	OLIGONUCLEOTIDE
Record UNII	5XE21E41RT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GIVOSIRAN SODIUM

Common Name

English

GIVOSIRAN SODIUM [MI]

Common Name

English

GIVOSIRAN SODIUM [ORANGE BOOK]

Common Name

English

Givosiran sodium [WHO-DD]

Common Name

English

GIVOSIRAN SODIUM [JAN]

Common Name

English

GIVLAARI

Brand Name

English

Code System Code Type Description

MERCK INDEX

m12182

Created by admin on Sat Dec 16 10:18:42 UTC 2023 , Edited by admin on Sat Dec 16 10:18:42 UTC 2023

PRIMARY

FDA UNII

5XE21E41RT

Created by admin on Sat Dec 16 10:18:42 UTC 2023 , Edited by admin on Sat Dec 16 10:18:42 UTC 2023

PRIMARY

DRUG BANK

DBSALT002906

Created by admin on Sat Dec 16 10:18:42 UTC 2023 , Edited by admin on Sat Dec 16 10:18:42 UTC 2023

PRIMARY

DAILYMED

5XE21E41RT

Created by admin on Sat Dec 16 10:18:42 UTC 2023 , Edited by admin on Sat Dec 16 10:18:42 UTC 2023

PRIMARY

RXCUI

2265859

Created by admin on Sat Dec 16 10:18:42 UTC 2023 , Edited by admin on Sat Dec 16 10:18:42 UTC 2023

PRIMARY

NCI_THESAURUS

C175519

Created by admin on Sat Dec 16 10:18:42 UTC 2023 , Edited by admin on Sat Dec 16 10:18:42 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_2-1_4;1_6;1_8;1_10;1_12;1_14;1_16;1_18;1_20;2_7;2_9;2_11;2_13;2_15	16 / 45
2'-O-Methyl-Ribose	1_1;1_5;1_7;1_9;1_11;1_13;1_15;1_17;1_19;1_21-1_23;2_1-2_6;2_8;2_10;2_12;2_14;2_16-2_22	29 / 45

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2-1_3;1_22-1_23;2_4-2_5	6 / 43
	1_4-1_21;2_4-2_22	37 / 43

Related Record Type Details


					ROV204583W

Givosiran

PARENT -> SALT/SOLVATE

Related Record Type Details


					ROV204583W

Givosiran

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[2_22]				GIVOSIRAN SODIUM TRIGLYCAN-END GROUP	8142CN1H73

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL