C-C CHEMOKINE RECEPTOR TYPE 2

Approval Year

Substance Class	Protein
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	5XA76PCG9F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

C-C CHEMOKINE RECEPTOR TYPE 2

Common Name

English

CCR-2

Preferred Name

English

MCP-1R

Common Name

English

MCP-1-R

Common Name

English

MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR

Common Name

English

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Code System

Code

Type

Description

FDA UNII

5XA76PCG9F

PRIMARY

UNIPROT

P41597

PRIMARY

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Subunit 0

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From	To
1_32	1_277
1_113	1_190

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Glycosylation Type

HUMAN

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Glycosylation Link Type	Site
N	1_14

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Related Record

Type

Details


					3UAA36FHF1

BMS-741672

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

1.1 NANOMOLAR [0.4 to 1.8] (average)


					380F68J5PH

ILACIRNON

INHIBITOR -> TARGET

Amount:

2.3 NANOMOLAR (average)


					P3LKY4ZL5O

MK-0812

INHIBITOR -> TARGET

Interaction Type:

BINDING

Qualification:

IC50

Amount:

5 NANOMOLAR (average)


					4XG66BMN0D

PLOZALIZUMAB

INHIBITOR -> TARGET

Amount:


					08379P260O

TIPELUKAST

INHIBITOR OF EXPRESSION->TARGET

Amount:

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_26]				TYROSINE O-SULFATE	29166358BF
AMINO ACID SUBSTITUTION	[1_139]				DEXFOSFOSERINE	VI4F0K069V

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL

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