OLIVACINE

CC1=NC=CC2=C(C)C3=C(C=C12)C4=C(N3)C=CC=C4

InChIKey=ZIXGXMMUKPLXBB-UHFFFAOYSA-N

InChI=1S/C17H14N2/c1-10-12-7-8-18-11(2)14(12)9-15-13-5-3-4-6-16(13)19-17(10)15/h3-9,19H,1-2H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Plasmodium falciparum (isolate K1 / Thailand) 8 Target ID: CHEMBL612856 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23092722	Inhibitor 8504		1.4 µM [IC50]
Plasmodium falciparum 3D7 7 Target ID: CHEMBL2366922 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23092722	Inhibitor 8504		1.2 µM [IC50]

PubMed

Title	Date	PubMed
Total Synthesis of Olivacine and Ellipticine via a Lactone Ring-Opening and Aromatization Cascade.	2019-06-21	31117560
Synthesis and Activity against Mycobacterium tuberculosis of Olivacine and Oxygenated Derivatives.	2018-06-09	29890747
Total synthesis of ellipticine quinones, olivacine, and calothrixin B.	2014-01-17	24372379
Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ellipticine, olivacine, cryptolepine and a synthetic cryptolepine analog.	2012-12-15	23092722
The olivacine derivative s 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide) induces CYP1A and its own metabolism in human hepatocytes in primary culture.	2004-01	14709624

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:19:35 GMT 2025` Edited by `admin` on `Mon Mar 31 21:19:35 GMT 2025`
Record UNII	5WSL5LL2C3
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

NSC-70134

Preferred Name

English

OLIVACINE

Common Name

English

OLIVACINE [MI]

Common Name

English

1,5-DIMETHYL-6H-PYRIDO(4,3-B)CARBAZOLE

Systematic Name

English

OLIVACIN

Common Name

English

GUATAMBUININE

Common Name

English

Code System Code Type Description

WIKIPEDIA

Olivacine