Nardosinone

[H][C@@]12CC(=O)C3=CCC[C@@H](C)[C@]3(C)[C@]1([H])C(C)(C)OO2

InChIKey=KXGHHSIMRWPVQM-JWFUOXDNSA-N

InChI=1S/C15H22O3/c1-9-6-5-7-10-11(16)8-12-13(15(9,10)4)14(2,3)18-17-12/h7,9,12-13H,5-6,8H2,1-4H3/t9-,12-,13+,15+/m1/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Targets

Primary Target	Pharmacology	Condition	Potency
nitric oxide production involved in inflammatory response 17 Target ID: GO:0002537 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22079762	Inhibitor 8297		11.1 µM [IC50]

PubMed

Title	Date	PubMed
Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages.	2012 Jan 1	22079762

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:57:31 GMT 2023` Edited by `admin` on `Sat Dec 16 08:57:31 GMT 2023`
Record UNII	5VA93HYL8U
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

Nardosinone

Common Name

English

Nardosinon

Common Name

English

5H-Naphtho[2,1-c][1,2]dioxol-5-one, 1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, [3aR-(3aα,9α,9aα,9bα)]-

Systematic Name

English

(3aR,9R,9aR,9bS)-1,3a,4,7,8,9,9a,9b-Octahydro-1,1,9,9a-tetramethyl-5H-naphtho[2,1-c][1,2]dioxol-5-one

Systematic Name

English

5H-Naphtho[2,1-c][1,2]dioxol-5-one, 1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)-

Systematic Name

English

Code System Code Type Description

FDA UNII

5VA93HYL8U