DIETHYLAMINE SALICYLATE

US Previously Marketed

First approved in 1958

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H6O3.C4H11N
Molecular Weight	211.2576
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCNCC.OC(=O)C1=C(O)C=CC=C1

InChI

InChIKey=JGMKRAUEFASZKH-UHFFFAOYSA-N

InChI=1S/C7H6O3.C4H11N/c8-6-4-2-1-3-5(6)7(9)10;1-3-5-4-2/h1-4,8H,(H,9,10);5H,3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C4H11N
Molecular Weight	73.1368
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C7H6O3
Molecular Weight	138.1207
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/uk/algesal-spc-11538.html
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/14757512 | https://www.ncbi.nlm.nih.gov/pubmed/12356424

Diethylamine salicylate is a salicylic acid salt, that is a cost-effective and simple, first-line treatment for rheumatic and minor musculoskeletal conditions including lumbago, fibrositis, sciatica, bruises, and strains. Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclooxygenase-2 201 Target ID: CHEMBL230 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5284360	Inhibitor 8504
Cyclooxygenase-1 131 Target ID: CHEMBL221 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5284360	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 619 Sources: https://www.drugs.com/uk/algesal-spc-11538.html	Primary		Approved 8583	Algesal Approved Use Unknown

Doses

Dose	Population	Adverse events
10 % 3 times / day multiple, topical Recommended Dose: 10 %, 3 times / day Route: topical Route: multiple Dose: 10 %, 3 times / day Sources: https://www.medicines.org.uk/emc/product/4815/smpc#POSOLOGY https://www.mims.com/philippines/drug/info/diethylamine%20salicylate?mtype=generic	unhealthy Health Status: unhealthy Sources: https://www.medicines.org.uk/emc/product/4815/smpc#POSOLOGY https://www.mims.com/philippines/drug/info/diethylamine%20salicylate?mtype=generic	Sources: https://www.medicines.org.uk/emc/product/4815/smpc#POSOLOGY https://www.mims.com/philippines/drug/info/diethylamine%20salicylate?mtype=generic

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-050801	http://www.3bsc.com/index/pro_info.php?id=88496
Aaron Chemicals	AR0072YJ	http://www.aaronchem.com/4419-92-5
Acorn PharmaTech	ACN-043120	http://www.acornpharmatech.com/
AHH Chemical co.,ltd	MT-09041	http://www.ahhchemical.com/product/MT-09041.html
AK Scientific, Inc. (AKSCI)	7849AF	http://www.aksci.com/item_detail.php?cat=7849AF
Alfa Chemistry	4419-92-5	https://www.alfa-chemistry.com/diethylamine-salicylate-cas-4419-92-5-item-292014.htm
Alichem	19095786	http://www.alichem.com/en/products/4419-92-5.html
Ambeed	A232281	https://www.ambeed.com/products/4419-92-5.html
Ark Pharm	AK397674	http://www.arkpharminc.com/products/4419-92-5.html
BLD Pharm	BD124834	http://www.bldpharm.com/products/4419-92-5.html
BOC Sciences	4419-92-5	https://www.bocsci.com/diethylamine-salicylate-cas-4419-92-5-item-118151.html
ChemMol	99095375	http://www.chemmol.com/chemmol/99095375.html
Chemspace	CSSB00020656914	https://chem-space.com/CSSB00020656914
Clearsynth	CS-P-04135	https://www.clearsynth.com/en/CSP04135.html
Debye Scientific	DB-051194	http://www.debyesci.com/cas_4419-92-5.html
eNovation Chemicals	D514772	https://www.enovationchem.com/ProductDetails.asp?ProductID=D514772
eNovation Chemicals	D957614	https://www.enovationchem.com/ProductDetails.asp?ProductID=D957614
Finetech	FT-0624875	http://www.finetechnology-ind.com/prod/detail/pub/4419-92-5.html
Hairui	HR125538	http://www.hairuichem.com/en/product/4419-92-5.html
LGC Standards	LGCFOR3461.00	https://www.lgcstandards.com/US/en/p/LGCFOR3461.00
LGC Standards	MM3461.00	https://www.lgcstandards.com/US/en/p/MM3461.00
MolPort	MolPort-039-141-153	https://www.molport.com/shop/molecule-link/MolPort-039-141-153
MuseChem	R036430	https://www.musechem.com/product/R036430.html

PubMed

Title	Date	PubMed
Differentiated in vivo skin penetration of salicylic compounds in hairless rats measured by cutaneous microdialysis.	2004-02	14757512

Patents

Sample Use Guides

In Vivo Use Guide

Topical As 10% cream: Apply 2-3 times/day.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:32:35 GMT 2025` Edited by `admin` on `Mon Mar 31 21:32:35 GMT 2025`
Record UNII	5V7PT38BJU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIETHYLAMINE SALICYLATE

Systematic Name

English

DIETHYLAMINE SALICYLATE [MART.]

Preferred Name

English

DIETHYLAMMONIUM SALICYLATE

Systematic Name

English

Diethylamine salicylate [WHO-DD]

Common Name

English

Code System Code Type Description

CAS

4419-92-5