DIETHYLAMINE SALICYLATE

US Previously Marketed

First approved in 1958

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H6O3.C4H11N
Molecular Weight	211.2576
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCNCC.OC(=O)C1=C(O)C=CC=C1

InChI

InChIKey=JGMKRAUEFASZKH-UHFFFAOYSA-N

InChI=1S/C7H6O3.C4H11N/c8-6-4-2-1-3-5(6)7(9)10;1-3-5-4-2/h1-4,8H,(H,9,10);5H,3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C4H11N
Molecular Weight	73.1368
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C7H6O3
Molecular Weight	138.1207
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/uk/algesal-spc-11538.html
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/14757512 | https://www.ncbi.nlm.nih.gov/pubmed/12356424

Diethylamine salicylate is a salicylic acid salt, that is a cost-effective and simple, first-line treatment for rheumatic and minor musculoskeletal conditions including lumbago, fibrositis, sciatica, bruises, and strains. Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclooxygenase-2 196 Target ID: CHEMBL230 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5284360	Inhibitor 8297
Cyclooxygenase-1 127 Target ID: CHEMBL221 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5284360	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.drugs.com/uk/algesal-spc-11538.html	Primary		Approved 8429	Algesal Approved Use Unknown

Doses

Dose	Population	Adverse events
10 % 3 times / day multiple, topical Recommended Dose: 10 %, 3 times / day Route: topical Route: multiple Dose: 10 %, 3 times / day Sources: https://www.medicines.org.uk/emc/product/4815/smpc#POSOLOGY https://www.mims.com/philippines/drug/info/diethylamine%20salicylate?mtype=generic	unhealthy Health Status: unhealthy Condition: Musculoskeletal pain Sources: https://www.medicines.org.uk/emc/product/4815/smpc#POSOLOGY https://www.mims.com/philippines/drug/info/diethylamine%20salicylate?mtype=generic	Sources: https://www.medicines.org.uk/emc/product/4815/smpc#POSOLOGY https://www.mims.com/philippines/drug/info/diethylamine%20salicylate?mtype=generic

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-050801	http://www.3bsc.com/index/pro_info.php?id=88496
AHH Chemical co.,ltd	MT-09041	http://www.ahhchemical.com/product/MT-09041.html
AK Scientific, Inc. (AKSCI)	7849AF	http://www.aksci.com/item_detail.php?cat=7849AF
Aaron Chemicals	AR0072YJ	http://www.aaronchem.com/4419-92-5
Acorn PharmaTech	ACN-043120	http://www.acornpharmatech.com/
Alfa Chemistry	4419-92-5	https://www.alfa-chemistry.com/diethylamine-salicylate-cas-4419-92-5-item-292014.htm
Alichem	19095786	http://www.alichem.com/en/products/4419-92-5.html
Ambeed	A232281	https://www.ambeed.com/products/4419-92-5.html
Ark Pharm	AK397674	http://www.arkpharminc.com/products/4419-92-5.html
BLD Pharm	BD124834	http://www.bldpharm.com/products/4419-92-5.html
BOC Sciences	4419-92-5	https://www.bocsci.com/diethylamine-salicylate-cas-4419-92-5-item-118151.html
ChemMol	99095375	http://www.chemmol.com/chemmol/99095375.html
Chemspace	CSSB00020656914	https://chem-space.com/CSSB00020656914
Clearsynth	CS-P-04135	https://www.clearsynth.com/en/CSP04135.html
Debye Scientific	DB-051194	http://www.debyesci.com/cas_4419-92-5.html
Finetech	FT-0624875	http://www.finetechnology-ind.com/prod/detail/pub/4419-92-5.html
Hairui	HR125538	http://www.hairuichem.com/en/product/4419-92-5.html
LGC Standards	LGCFOR3461.00	https://www.lgcstandards.com/US/en/p/LGCFOR3461.00
LGC Standards	MM3461.00	https://www.lgcstandards.com/US/en/p/MM3461.00
MolPort	MolPort-039-141-153	https://www.molport.com/shop/molecule-link/MolPort-039-141-153
MuseChem	R036430	https://www.musechem.com/product/R036430.html
eNovation Chemicals	D514772	https://www.enovationchem.com/ProductDetails.asp?ProductID=D514772
eNovation Chemicals	D957614	https://www.enovationchem.com/ProductDetails.asp?ProductID=D957614

PubMed

Title	Date	PubMed
Differentiated in vivo skin penetration of salicylic compounds in hairless rats measured by cutaneous microdialysis.	2004 Feb	14757512

Patents

Sample Use Guides

In Vivo Use Guide

Topical As 10% cream: Apply 2-3 times/day.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:43:26 GMT 2023` Edited by `admin` on `Sat Dec 16 05:43:26 GMT 2023`
Record UNII	5V7PT38BJU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIETHYLAMINE SALICYLATE

Systematic Name

English

DIETHYLAMINE SALICYLATE [MART.]

Common Name

English

DIETHYLAMMONIUM SALICYLATE

Systematic Name

English

Diethylamine salicylate [WHO-DD]

Common Name

English

Code System Code Type Description

CAS

4419-92-5