Abamectin is a mixture of avermectins containing avermectin B1a and avermectin B1b. These two components, B1a and B1b have very similar biological and toxicological properties. The avermectins are insecticidal or anthelmintic compounds derived from the soil bacterium Streptomyces avermitilis. Abamectin is used to control insect and mite pests of a range of agronomic, fruit, vegetable and ornamental crops and it is used by homeowners for control of fire ants. Abamectin acts on insects by interfering with neural and neuromuscular transmission. Abamectin attenuated ethanol-induced gastric ulceration. Chemical structure and effects on GABAARs and P2X4Rs receptor function play key roles in the ability of avermectin to reduce ethanol intake
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The cytotoxicity of abamectin to the Gill Cell Line of Flounder (FG cell line) was examined. It was revealed that the proliferation of the cells was inhibited at all concentrations of abamectin tested. The cell density was 3.38×10^3 cells mm-2 after culture for 8 days. When the cells were cultured in the presence of 5, 10, 15 and 20 μmolL-1 abamectin for the same periods, the cell densities were reduced to 2.99×10^3 , 2.50×10^3 , 2.16×10^3 and 1.59×10^3 cells mm-2, respectively.
