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Details

Stereochemistry ACHIRAL
Molecular Formula C12H8Cl2O2S
Molecular Weight 287.162
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 4,4'-DICHLORODIPHENYL SULFONE

SMILES

ClC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(Cl)C=C2

InChI

InChIKey=GPAPPPVRLPGFEQ-UHFFFAOYSA-N
InChI=1S/C12H8Cl2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H

HIDE SMILES / InChI

Molecular Formula C12H8Cl2O2S
Molecular Weight 287.162
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

DCDPS, 4,4'-dichlorodiphenyl sulfone, is a monomer used for polymerization into polysulfone homopolymers and copolymers. High performance sulfones are categorized by high transparency and high temperature performance. Sulfones are used as replacements for metals and glass in a wide range of medical, automotive, aerospace and consumer products. There was no evidence of carcinogenic activity of 4,4'-dichlorodiphenyl sulfone sulfone in male F344/N rats exposed to 10, 30, or 100 ppm or in female F344/N rats exposed to 30, 100, or 300 ppm. There was no evidence of carcinogenic activity of p,p'-dichlorodiphenyl sulfone in male or female B6C3F1 mice exposed to 30, 100, or 300 ppm. Exposure to 4,4'-dichlorodiphenyl sulfone for 2 years caused increased incidences of nonneoplastic lesions of the liver in male and female rats and mice.

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Sample Use Guides

In Vivo Use Guide
Groups of 10 male and 10 female B6C3F1 mice were fed diets containing 0, 30, 100, 300, 1,000, or 3,000 ppm 4,4'-dichlorodiphenyl sulfone (equivalent to average daily doses of approximately 3.5, 15, 50, 165, or 480 mg/kg) for 14 weeks. All mice survived until the end of the study. Mean body weights of groups exposed to 300 ppm or greater were significantly less than those of the controls. Liver weights of groups exposed to 300 ppm or greater were significantly increased. Centrilobular hypertrophy of the liver was observed in most males exposed to 100 ppm or greater and in all females exposed to 1,000 or 3,000 ppm, and the severities generally increased with increasing exposure concentration.
Route of Administration: Oral
In Vitro Use Guide
In a 500 mL three-necked round bottom flask fitted with a Dean-Stark trap, a condenser, a nitrogen inlet, and a thermometer, 0.1 mol of hydroquinone, 0.1 mol of 4,4’-dichlorodiphenyl sulfone, and 0.15 mol of K2CO3 were dissolved in a mixture of NMP-toluene (2:1) by heating (raised to 190 °C) and continuous stirring.
Substance Class Chemical
Record UNII
5U49794253
Record Status Validated (UNII)
Record Version