Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H8Cl2O2S |
| Molecular Weight | 287.162 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(Cl)C=C2
InChI
InChIKey=GPAPPPVRLPGFEQ-UHFFFAOYSA-N
InChI=1S/C12H8Cl2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H
| Molecular Formula | C12H8Cl2O2S |
| Molecular Weight | 287.162 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DCDPS, 4,4'-dichlorodiphenyl sulfone, is a monomer used for polymerization into polysulfone homopolymers and copolymers. High performance sulfones are categorized by high transparency and high temperature performance. Sulfones are used as replacements for metals and glass in a wide range of medical, automotive, aerospace and consumer products. There was no evidence of carcinogenic activity of 4,4'-dichlorodiphenyl sulfone sulfone in male F344/N rats exposed to 10, 30, or 100 ppm or in female F344/N rats exposed to 30, 100, or 300 ppm. There was no evidence of carcinogenic activity of p,p'-dichlorodiphenyl sulfone in male or female B6C3F1 mice exposed to 30, 100, or 300 ppm. Exposure to 4,4'-dichlorodiphenyl sulfone for 2 years caused increased incidences of nonneoplastic lesions of the liver in male and female rats and mice.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Synthesis and drug release properties of poly(ethylene oxide) segmented polysulfone copolymers. | 2008-05-08 |
|
| Bis[4-(2-hydroxy-ethyl-amino)phen-yl] sulfone. | 2007-12-06 |
|
| Temporal trend of bis(4-chlorophenyl) sulfone, methylsulfonyl-DDE and -PCBs in Baltic guillemot (Uria aalge) egg 1971-2001--a comparison to 4,4'-DDE and PCB trends. | 2006-05 |
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| New organochlorine contaminants and metabolites in plasma and eggs of glaucous gulls (Larus hyperboreus) from the Norwegian Arctic. | 2005-10 |
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| Explanation of the glasslike anomaly in the low-temperature specific heat of incommensurate phases. | 2004-12-10 |
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| Enantiomeric specificity of methylsulfonyl-PCBs and distribution of bis(4-chlorophenyl) sulfone, PCB, and DDE methyl sulfones in grey seal tissues. | 2004-10-01 |
|
| Bis(4-chlorophenyl) sulfone (BCPS) in Swedish marine and fresh water wildlife-a screening study. | 2004-07 |
|
| Indications of hormonally active substances in municipal solid waste leachate: mobilization and effect studies from Sweden and Norway. | 2004 |
|
| The role of DDE, PCB, coplanar PCB and eggshell parameters for reproduction in the white-tailed sea eagle (Haliaeetus albicilla) in Sweden. | 2002-08 |
|
| A physiologically based pharmacokinetic model of p,p'-dichlorodiphenylsulfone. | 2002-06-15 |
|
| Dynamics of the pinned modulation wave in incommensurate bis (4-chlorophenyl) sulfone (BCPS). | 2002-01-07 |
|
| Nonylphenols, nonylphenol-ethoxylates, linear alkylbenzenesulfonates (LAS) and bis (4-chlorophenyl)-sulfone in the German Bight of the North Sea. | 2001-11 |
|
| Toxicology and carcinogenesis studies of p,p'-dichlorophenyl sulfone (CAS No. 80-07-9) in F344/N rats and B6C3F1 mice (feed studies). | 2001-09 |
|
| Structural characterization of quinoxaline homopolymers and quinoxaline/ether sulfone copolymers by matrix-assisted laser desorption ionization mass spectrometry. | 2001-05-01 |
|
| Toxicology and carcinogenesis studies of p,p'-dichlorodiphenyl sulfone in rats and mice. | 2001-03 |
Sample Use Guides
Groups of 10 male and 10 female B6C3F1 mice were fed diets containing 0, 30, 100, 300, 1,000, or 3,000 ppm 4,4'-dichlorodiphenyl sulfone (equivalent to average daily doses of approximately 3.5, 15, 50, 165, or 480 mg/kg) for 14 weeks. All mice survived until the end of the study. Mean body weights of groups exposed to 300 ppm or greater were significantly less than those of the controls. Liver weights of groups exposed to 300 ppm or greater were significantly increased. Centrilobular hypertrophy of the liver was observed in most males exposed to 100 ppm or greater and in all females exposed to 1,000 or 3,000 ppm, and the severities generally increased with increasing exposure concentration.
Route of Administration:
Oral
In a 500 mL three-necked round bottom flask fitted with a Dean-Stark trap, a condenser, a nitrogen inlet, and a thermometer, 0.1 mol of hydroquinone, 0.1 mol of 4,4’-dichlorodiphenyl sulfone, and 0.15 mol of K2CO3 were dissolved in a mixture of NMP-toluene (2:1) by heating (raised to 190 °C) and continuous stirring.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:50:11 GMT 2025
by
admin
on
Mon Mar 31 22:50:11 GMT 2025
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| Record UNII |
5U49794253
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| Record Status |
Validated (UNII)
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| Record Version |
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80-07-9
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5233
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5U49794253
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6625
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23899
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201-247-9
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DTXSID9024986
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4,4'-Dichlorodiphenyl sulfone
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