5HPP-33

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H21NO3
Molecular Weight	323.3856
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C1=CC=CC(C(C)C)=C1N2C(=O)C3=C(C=C(O)C=C3)C2=O

InChI

InChIKey=LAKWINYVWJPHQW-UHFFFAOYSA-N

InChI=1S/C20H21NO3/c1-11(2)14-6-5-7-15(12(3)4)18(14)21-19(23)16-9-8-13(22)10-17(16)20(21)24/h5-12,22H,1-4H3

HIDE SMILES / InChI

Molecular Formula	C20H21NO3
Molecular Weight	323.3856
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Tubulin polymerization 1 Target ID: Tubulin polymerization Sources: https://www.ncbi.nlm.nih.gov/pubmed/15603947	Inhibitor 8297
NF-kappaB activation 1 Target ID: NF-kappaB activation Sources: https://www.ncbi.nlm.nih.gov/pubmed/17845850 \| https://www.ncbi.nlm.nih.gov/pubmed/23018603	Inhibitor 8297

PubMed

Title	Date	PubMed
A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities.	2006 Feb	16505120
Structure-activity relationship studies of thalidomide analogs with a taxol-like mode of action.	2013 Dec 15	24169233
Embryonic vascular disruption adverse outcomes: Linking high-throughput signaling signatures with functional consequences.	2017 Aug	28414088

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:34:25 GMT 2023` Edited by `admin` on `Sat Dec 16 09:34:25 GMT 2023`
Record UNII	5SZ69PBV5B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

5HPP-33

Code

English

2-(2,6-DIISOPROPYLPHENYL)-5-HYDROXYISOINDOLINE-1,3-DIONE

Systematic Name

English

2-(2,6-BIS(1-METHYLETHYL)PHENYL)-5-HYDROXY-1H-ISOINDOLE-1,3(2H)-DIONE

Systematic Name

English

1H-ISOINDOLE-1,3(2H)-DIONE, 2-(2,6-BIS(1-METHYLETHYL)PHENYL)-5-HYDROXY-

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID1046970

Created by admin on Sat Dec 16 09:34:25 GMT 2023 , Edited by admin on Sat Dec 16 09:34:25 GMT 2023

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PUBCHEM

11723708

Created by admin on Sat Dec 16 09:34:25 GMT 2023 , Edited by admin on Sat Dec 16 09:34:25 GMT 2023

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CAS

105624-86-0

Created by admin on Sat Dec 16 09:34:25 GMT 2023 , Edited by admin on Sat Dec 16 09:34:25 GMT 2023

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FDA UNII

5SZ69PBV5B

Created by admin on Sat Dec 16 09:34:25 GMT 2023 , Edited by admin on Sat Dec 16 09:34:25 GMT 2023

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