Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C32H35F3N4O5S.C7H8O3S |
| Molecular Weight | 816.906 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC=C(C=C1)S(O)(=O)=O.CCCS(=O)(=O)N2CCN(CC3=CC=C(NC(=O)C4=CC=C(C=C4)C5=CC(NC(=O)C6CC6)=CC=C5OC(F)(F)F)C=C3)CC2
InChI
InChIKey=LLZXGLMVVXUEOP-UHFFFAOYSA-N
InChI=1S/C32H35F3N4O5S.C7H8O3S/c1-2-19-45(42,43)39-17-15-38(16-18-39)21-22-3-11-26(12-4-22)36-30(40)24-7-5-23(6-8-24)28-20-27(37-31(41)25-9-10-25)13-14-29(28)44-32(33,34)35;1-6-2-4-7(5-3-6)11(8,9)10/h3-8,11-14,20,25H,2,9-10,15-19,21H2,1H3,(H,36,40)(H,37,41);2-5H,1H3,(H,8,9,10)
| Molecular Formula | C7H8O3S |
| Molecular Weight | 172.202 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C32H35F3N4O5S |
| Molecular Weight | 644.704 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
A-689 (AZD-7295) was the lead compound from Arrow Therapeutics' second series of hepatitis C virus (HCV) NS5a inhibitors. AZD-7295 is a selective inhibitor of HCV NS5A within vitroantiviral activity of 7nM and 1.24mM against HCV genotype1b and 1a replicons respectively, with significant liver concentrationin preclinical studies. AZD-7295 was well tolerated at repeated doses ofup to 700 mg daily. AZD-7295 shows potent antiviral activity ingenotype 1b patients. Genotype 1a and genotype 3 patients showedno antiviral effects.
Originator
Approval Year
Sample Use Guides
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 19:14:19 GMT 2025
by
admin
on
Wed Apr 02 19:14:19 GMT 2025
|
| Record UNII |
5SQP3W5X7K
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
Download
| Name | Type | Language | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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5SQP3W5X7K
Created by
admin on Wed Apr 02 19:14:19 GMT 2025 , Edited by admin on Wed Apr 02 19:14:19 GMT 2025
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |
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