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Details

Stereochemistry ACHIRAL
Molecular Formula 2C29H44N8O3.C4H4O4
Molecular Weight 1221.4951
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of GILTERITINIB FUMARATE

SMILES

OC(=O)\C=C\C(O)=O.CCC1=C(NC2CCOCC2)N=C(NC3=CC=C(N4CCC(CC4)N5CCN(C)CC5)C(OC)=C3)C(=N1)C(N)=O.CCC6=C(NC7CCOCC7)N=C(NC8=CC=C(N9CCC(CC9)N%10CCN(C)CC%10)C(OC)=C8)C(=N6)C(N)=O

InChI

InChIKey=UJOUWHLYTQFUCU-WXXKFALUSA-N
InChI=1S/2C29H44N8O3.C4H4O4/c2*1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36;5-3(6)1-2-4(7)8/h2*5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34);1-2H,(H,5,6)(H,7,8)/b;;2-1+

HIDE SMILES / InChI

Molecular Formula C29H44N8O3
Molecular Weight 552.7115
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://ash.confex.com/ash/2016/webprogram/Paper92543.html | http://www.activebiochem.com/Product/Gilteritinib.html | https://www.ncbi.nlm.nih.gov/pubmed/26279055 | https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/211349Orig1s000MultidisciplineR.pdf

Gilteritinib, also known as ASP2215, is a potent FLT3/AXL inhibitor, which showed potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations. In in vitro, among the 78 tyrosine kinases tested, Gilteritinib inhibited FLT3, LTK, ALK, and AXL kinases by over 50% at 1 nM with an IC50 value of 0.29 nM for FLT3, approximately 800-fold more potent than for c-KIT, the inhibition of which is linked to a potential risk of myelosuppression. Gilteritinib inhibited the growth of MV4-11 cells, which harbor FLT3-ITD, with an IC50 value of 0.92 nM, accompanied with inhibition of pFLT3, pAKT, pSTAT5, pERK, and pS6. Gilteritinib decreased tumor burden in bone marrow and prolonged the survival of mice intravenously transplanted with MV4-11 cells. In previous preclinical studies, gilteritinib has demonstrated superior antitumor effects when given in combination with AraC and either DNR or IDR compared with combination chemotherapy. In November 2018, the FDA approved gilteritinib for treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation as detected by an FDA-approved test.

CNS Activity

Curator's Comment: Concentrations were highest in the liver, then spleen, kidneys, adrenal glands and lung; and lowest in the plasma, followed by the testes, brain and blood

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
XOSPATA

Approved Use

XOSPATA is a kinase inhibitor indicated for the treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation as detected by an FDA-approved test.

Launch Date

1.54327686E12
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
137 ng/mL
300 mg single, oral
dose: 300 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
1257 ng/mL
300 mg 1 times / day multiple, oral
dose: 300 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
216 ng/mL
450 mg single, oral
dose: 450 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
216.38 ng/mL
120 mg single, oral
dose: 120 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
1528 ng/mL
450 mg 1 times / day multiple, oral
dose: 450 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
374 ng/mL
120 mg 1 times / day steady-state, oral
dose: 120 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
374 ng/mL
120 mg 1 times / day steady-state, oral
dose: 120 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
GILTERITINIB unknown
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
107.6 ng/mL
40 mg 1 times / day steady, oral
dose: 40 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
136.7 ng/mL
120 mg single, oral
dose: 120 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
1462 ng/mL
200 mg 1 times / day steady, oral
dose: 200 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
1525 ng/mL
300 mg 1 times / day steady, oral
dose: 300 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
1528 ng/mL
450 mg 1 times / day steady, oral
dose: 450 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
168.2 ng/mL
200 mg single, oral
dose: 200 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
204.3 ng/mL
300 mg single, oral
dose: 300 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
207.6 ng/mL
450 mg single, oral
dose: 450 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
24.9799999999999 ng/mL
40 mg single, oral
dose: 40 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
374.2 ng/mL
120 mg 1 times / day steady, oral
dose: 120 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
376.4 ng/mL
80 mg 1 times / day steady, oral
dose: 80 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
75.29 ng/mL
80 mg single, oral
dose: 80 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
2446 ng × h/mL
300 mg single, oral
dose: 300 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
28711 ng × h/mL
300 mg 1 times / day multiple, oral
dose: 300 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
3324 ng × h/mL
450 mg single, oral
dose: 450 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
3340.23 ng × h/mL
120 mg single, oral
dose: 120 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
37468 ng × h/mL
450 mg 1 times / day multiple, oral
dose: 450 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
6943 ng × h/mL
120 mg 1 times / day steady-state, oral
dose: 120 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
6943 ng × h/mL
120 mg 1 times / day steady-state, oral
dose: 120 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
GILTERITINIB unknown
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
1216 ng*h/mL
80 mg single, oral
dose: 80 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
2480 ng*h/mL
120 mg single, oral
dose: 120 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
2482 ng*h/mL
40 mg 1 times / day steady, oral
dose: 40 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
3022 ng*h/mL
200 mg single, oral
dose: 200 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
31005 ng*h/mL
300 mg 1 times / day steady, oral
dose: 300 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
31428 ng*h/mL
200 mg 1 times / day steady, oral
dose: 200 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
3324 ng*h/mL
450 mg single, oral
dose: 450 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
34768 ng*h/mL
450 mg 1 times / day steady, oral
dose: 450 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
360 ng*h/mL
40 mg single, oral
dose: 40 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
4163 ng*h/mL
300 mg single, oral
dose: 300 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
6943 ng*h/mL
120 mg 1 times / day steady, oral
dose: 120 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
6958 ng*h/mL
80 mg 1 times / day steady, oral
dose: 80 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
1216 ng*h/mL
80 mg single, oral
dose: 80 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
1990 ng*h/mL
40 mg 1 times / day steady, oral
dose: 40 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
2480 ng*h/mL
120 mg single, oral
dose: 120 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
2544 ng*h/mL
450 mg single, oral
dose: 450 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
3024 ng*h/mL
200 mg single, oral
dose: 200 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
31749 ng*h/mL
300 mg 1 times / day steady, oral
dose: 300 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
32248 ng*h/mL
200 mg 1 times / day steady, oral
dose: 200 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
35506 ng*h/mL
450 mg 1 times / day steady, oral
dose: 450 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
360.4 ng*h/mL
40 mg single, oral
dose: 40 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
4181 ng*h/mL
300 mg single, oral
dose: 300 mg
route of administration: oral
experiment type: single
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
6943 ng*h/mL
120 mg 1 times / day steady, oral
dose: 120 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
7111 ng*h/mL
80 mg 1 times / day steady, oral
dose: 80 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
159 h
300 mg 1 times / day multiple, oral
dose: 300 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
84 h
120 mg single, oral
dose: 120 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
113 h
120 mg 1 times / day steady-state, oral
dose: 120 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
113 h
120 mg 1 times / day steady-state, oral
dose: 120 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
GILTERITINIB unknown
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
45.8499999999999 h
120 mg 1 times / day steady, oral
dose: 120 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
141.9 h
200 mg 1 times / day steady, oral
dose: 200 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
142.2 h
300 mg 1 times / day steady, oral
dose: 300 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
151.8 h
40 mg 1 times / day steady, oral
dose: 40 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
86.11 h
80 mg 1 times / day steady, oral
dose: 80 mg
route of administration: oral
experiment type: steady
co-administered:
GILTERITINIB plasma
Homo sapiens
population: unhealthy
age:
sex:
food status:
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
6%
300 mg single, oral
dose: 300 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
6%
300 mg 1 times / day multiple, oral
dose: 300 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
6%
450 mg single, oral
dose: 450 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
6%
450 mg 1 times / day multiple, oral
dose: 450 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
GILTERITINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
6%
120 mg 1 times / day steady-state, oral
dose: 120 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
GILTERITINIB unknown
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
6%
GILTERITINIB plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
300 mg 1 times / day multiple, oral
MTD
Dose: 300 mg, 1 times / day
Route: oral
Route: multiple
Dose: 300 mg, 1 times / day
Sources:
unhealthy, 62 years (range: 21–90 years)
n = 252
Health Status: unhealthy
Condition: relapsed AML | refractory FLT3 mutation-positive AML
Age Group: 62 years (range: 21–90 years)
Sex: M+F
Population Size: 252
Sources:
300 mg single, oral
MTD
unhealthy, 62 years (range: 21–90 years)
n = 252
Health Status: unhealthy
Condition: relapsed AML | refractory FLT3 mutation-positive AML
Age Group: 62 years (range: 21–90 years)
Sex: M+F
Population Size: 252
Sources:
450 mg 1 times / day multiple, oral
Dose: 450 mg, 1 times / day
Route: oral
Route: multiple
Dose: 450 mg, 1 times / day
Sources:
unhealthy, 62 years (range: 21–90 years)
n = 252
Health Status: unhealthy
Condition: relapsed AML | refractory FLT3 mutation-positive AML
Age Group: 62 years (range: 21–90 years)
Sex: M+F
Population Size: 252
Sources:
450 mg single, oral
Dose: 450 mg
Route: oral
Route: single
Dose: 450 mg
Sources:
unhealthy, 62 years (range: 21–90 years)
n = 252
Health Status: unhealthy
Condition: relapsed AML | refractory FLT3 mutation-positive AML
Age Group: 62 years (range: 21–90 years)
Sex: M+F
Population Size: 252
Sources:
120 mg 1 times / day steady, oral
Recommended
Dose: 120 mg, 1 times / day
Route: oral
Route: steady
Dose: 120 mg, 1 times / day
Sources:
unhealthy
n = 292
Health Status: unhealthy
Condition: relapsed AML | refractory AML
Population Size: 292
Sources:
Disc. AE: Pneumonia, Sepsis...
AEs leading to
discontinuation/dose reduction:
Pneumonia (2%)
Sepsis (2%)
Dyspnea (1%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Dyspnea 1%
Disc. AE
120 mg 1 times / day steady, oral
Recommended
Dose: 120 mg, 1 times / day
Route: oral
Route: steady
Dose: 120 mg, 1 times / day
Sources:
unhealthy
n = 292
Health Status: unhealthy
Condition: relapsed AML | refractory AML
Population Size: 292
Sources:
Pneumonia 2%
Disc. AE
120 mg 1 times / day steady, oral
Recommended
Dose: 120 mg, 1 times / day
Route: oral
Route: steady
Dose: 120 mg, 1 times / day
Sources:
unhealthy
n = 292
Health Status: unhealthy
Condition: relapsed AML | refractory AML
Population Size: 292
Sources:
Sepsis 2%
Disc. AE
120 mg 1 times / day steady, oral
Recommended
Dose: 120 mg, 1 times / day
Route: oral
Route: steady
Dose: 120 mg, 1 times / day
Sources:
unhealthy
n = 292
Health Status: unhealthy
Condition: relapsed AML | refractory AML
Population Size: 292
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG


OverviewOther

Other InhibitorOther SubstrateOther Inducer








Drug as perpetrator​Drug as victimTox targets

Tox targets

PubMed

PubMed

TitleDatePubMed
FLT3 Inhibitors for Treating Acute Myeloid Leukemia.
2016 Oct
Patents

Patents

Sample Use Guides

120 mg orally once-daily
Route of Administration: Oral
Gilteritinib inhibited the growth of MV4-11 cells, which harbor FLT3-ITD, with an IC50 value of 0.92 nM
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:53:34 UTC 2023
Edited
by admin
on Sat Dec 16 08:53:34 UTC 2023
Record UNII
5RZZ0Z1GJT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GILTERITINIB FUMARATE
USAN   WHO-DD  
USAN  
Official Name English
Gilteritinib fumarate [WHO-DD]
Common Name English
GILTERITINIB HEMIFUMARATE
Common Name English
GILTERITINIB FUMARATE [USAN]
Common Name English
XOSPATA
Brand Name English
2-PYRAZINECARBOXAMIDE, 6-ETHYL-3-((3-METHOXY-4-(4-(4-METHYL-1-PIPERAZINYL)-1-PIPERIDINYL)PHENYL)AMINO)-5-((TETRAHYDRO-2H-PYRAN-4-YL)AMINO)-, (2E)-2-BUTENEDIOATE (2:1)
Systematic Name English
ASP2215 HEMIFUMARATE
Code English
GILTERITINIB FUMARATE [JAN]
Common Name English
ASP-2215 HEMIFUMARATE
Code English
GILTERITINIB FUMARATE [ORANGE BOOK]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1967
Created by admin on Sat Dec 16 08:53:35 UTC 2023 , Edited by admin on Sat Dec 16 08:53:35 UTC 2023
Code System Code Type Description
CAS
1254053-84-3
Created by admin on Sat Dec 16 08:53:35 UTC 2023 , Edited by admin on Sat Dec 16 08:53:35 UTC 2023
PRIMARY
RXCUI
2105823
Created by admin on Sat Dec 16 08:53:35 UTC 2023 , Edited by admin on Sat Dec 16 08:53:35 UTC 2023
PRIMARY
PUBCHEM
76970819
Created by admin on Sat Dec 16 08:53:35 UTC 2023 , Edited by admin on Sat Dec 16 08:53:35 UTC 2023
PRIMARY
CHEBI
145372
Created by admin on Sat Dec 16 08:53:35 UTC 2023 , Edited by admin on Sat Dec 16 08:53:35 UTC 2023
PRIMARY
FDA UNII
5RZZ0Z1GJT
Created by admin on Sat Dec 16 08:53:35 UTC 2023 , Edited by admin on Sat Dec 16 08:53:35 UTC 2023
PRIMARY
ChEMBL
CHEMBL3301622
Created by admin on Sat Dec 16 08:53:35 UTC 2023 , Edited by admin on Sat Dec 16 08:53:35 UTC 2023
PRIMARY
DRUG BANK
DBSALT002819
Created by admin on Sat Dec 16 08:53:35 UTC 2023 , Edited by admin on Sat Dec 16 08:53:35 UTC 2023
PRIMARY
DAILYMED
5RZZ0Z1GJT
Created by admin on Sat Dec 16 08:53:35 UTC 2023 , Edited by admin on Sat Dec 16 08:53:35 UTC 2023
PRIMARY
USAN
BC-52
Created by admin on Sat Dec 16 08:53:35 UTC 2023 , Edited by admin on Sat Dec 16 08:53:35 UTC 2023
PRIMARY
SMS_ID
100000181875
Created by admin on Sat Dec 16 08:53:35 UTC 2023 , Edited by admin on Sat Dec 16 08:53:35 UTC 2023
PRIMARY
EPA CompTox
DTXSID001027950
Created by admin on Sat Dec 16 08:53:35 UTC 2023 , Edited by admin on Sat Dec 16 08:53:35 UTC 2023
PRIMARY
NCI_THESAURUS
C119665
Created by admin on Sat Dec 16 08:53:35 UTC 2023 , Edited by admin on Sat Dec 16 08:53:35 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY