Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H5NS2 |
| Molecular Weight | 167.251 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
SC1=NC2=C(S1)C=CC=C2
InChI
InChIKey=YXIWHUQXZSMYRE-UHFFFAOYSA-N
InChI=1S/C7H5NS2/c9-7-8-5-3-1-2-4-6(5)10-7/h1-4H,(H,8,9)
| Molecular Formula | C7H5NS2 |
| Molecular Weight | 167.251 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionSources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6bead357-f409-47aa-8cdd-d8676b7a5960https://www.cdc.gov/niosh/docs/2014-142/pdfs/2014-142.pdf | https://hazmap.nlm.nih.gov/category-details?table=copytblagents&id=7051 | http://www.emeraldmaterials.com/cms/polyadd/fis_ftp.downloadMSDS?p_filename=NAMBT_GOOD-RITE_%20SODIUM%20MBT%20Corrosion%20Inhibitor_GHS%20Internatl_English_POLADD.pdfCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19158128
https://www.ncbi.nlm.nih.gov/pubmed/12732904
Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6bead357-f409-47aa-8cdd-d8676b7a5960https://www.cdc.gov/niosh/docs/2014-142/pdfs/2014-142.pdf | https://hazmap.nlm.nih.gov/category-details?table=copytblagents&id=7051 | http://www.emeraldmaterials.com/cms/polyadd/fis_ftp.downloadMSDS?p_filename=NAMBT_GOOD-RITE_%20SODIUM%20MBT%20Corrosion%20Inhibitor_GHS%20Internatl_English_POLADD.pdf
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19158128
https://www.ncbi.nlm.nih.gov/pubmed/12732904
Sodium 2-Mercaptobenzothiazole (sodium MBT) is utilized as a
corrosion inhibitor and fungicide. By analogy to MBT, sodium MBT
is identified as a skin sensitizer. Sodium 2-Mercaptobenzothiazole is also used to make rubber accelerators, as a preservative for latex paint and wood, a metal chelator, and a thermal stabilizer (methyl methacrylate copolymers, acrylonitrile polymers, polyester fibers, anion exchange resins, polyoxyphenylene, and silicon fluids), also used in electroplating (silver, nickel, and cobalt), to separate sulfide ore from copper ore, for dyeing textiles, in transmission fluids, and to prevent discoloration of freeze dried bananas; uses of 50% aqueous solution include as a corrosion inhibitor for nonferrous metals in antifreeze and coolants and in paper mill systems; used as a biocide in metalworking fluids and paper manufacturing.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Contact dermatitis in students practicing sports: incidence of rubber sensitisation. | 2001 Apr |
|
| [Residual chemicals in natural rubber products for food contact use]. | 2001 Jun |
|
| [Occupational diseases among personnel of Polish hospitals, 2001]. | 2002 |
|
| Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers. | 2002 Dec |
|
| Organometallic radical-initiated cleavage of the metal chelate and thiazole rings in a cyclopentadienylchromium complex. | 2002 Jul 31 |
|
| Diagnostic screening for contact allergy to mercaptobenzothiazole derivatives. | 2002 Jun |
|
| Indirect extraction-spectrophotometric determination of 2-(thiocyanomethylthiol)benzothiazole in chrome tanning liquors after its breakdown to 2-mercaptobenzothiazole. | 2002 Mar 4 |
|
| Synthesis, structural characterization and in vitro cytotoxicity of organotin(IV) derivatives of heterocyclic thioamides, 2-mercaptobenzothiazole, 5-chloro-2-mercaptobenzothiazole, 3-methyl-2-mercaptobenzothiazole and 2-mercaptonicotinic acid. | 2003 Aug 1 |
|
| Common shoe allergens undetected by commercial patch-testing kits: dithiodimorpholine and isocyanates. | 2003 Jun |
|
| Studies in polyphenol chemistry and bioactivity. 4.(1) Synthesis of trimeric, tetrameric, pentameric, and higher oligomeric epicatechin-derived procyanidins having all-4beta,8-interflavan connectivity and their inhibition of cancer cell growth through cell cycle arrest. | 2003 Mar 7 |
|
| Determination of 2-mercaptobenzothiazole (MBT) in tannery wastewater by high performance liquid chromatography with amperometric detection. | 2004 Nov |
|
| Metabolism of 2-mercaptobenzothiazole by Rhodococcus rhodochrous. | 2004 Oct |
|
| A wood preservative metabolite in river water. | 2005 |
|
| Comparative aquatic toxicity evaluation of 2-(thiocyanomethylthio)benzothiazole and selected degradation products using Ceriodaphnia dubia. | 2005 Apr |
|
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. | 2005 Mar 24 |
|
| In vitro induction of polyploidy and chromatid exchanges by culture medium extracts of natural rubbers compounded with 2-mercaptobenzothiazole as a positive control candidate for genotoxicity tests. | 2005 Nov 1 |
|
| Electroreduction of the antifouling agent TCMTB and its electroanalytical determination in tannery wastewaters. | 2005 Oct 15 |
|
| MIP-1beta, a novel biomarker for in vitro sensitization test using human monocytic cell line. | 2006 Aug |
|
| FTIR, Raman spectra and ab initio calculations of 2-mercaptobenzothiazole. | 2006 Feb |
|
| Preparation of 2-mercaptobenzothiazole-derivatized mesoporous silica and removal of Hg(ii) from aqueous solution. | 2006 Jan |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
|
| Respective contributions of polar vs enthalpy effects in the addition/fragmentation of mercaptobenzoxazole-derived thiyl radicals and analogues to double bonds. | 2006 Oct 19 |
|
| Predicting the efficiencies of 2-mercaptobenzothiazole collectors used as chelating agents in flotation processes: a density-functional study. | 2006 Sep |
|
| 20 Years of standard patch testing in an eczema population with focus on patients with multiple contact allergies. | 2007 Aug |
|
| [Occupational contact dermatitis in metal workers and gender effect]. | 2007 Jul-Sep |
|
| Acetylcholinesterase-polyaniline biosensor investigation of organophosphate pesticides in selected organic solvents. | 2007 Mar-Apr |
|
| Epidemio-allergological study in 155 cases of footwear dermatitis. | 2007 Sep-Oct |
|
| Mercaptobenzothiazole allergenicity-role of the thiol group. | 2008 |
|
| A collaborative epidemiological investigation into the criminal fake artesunate trade in South East Asia. | 2008 Feb |
|
| A combined patch-clamp and electrorotation study of the voltage- and frequency-dependent membrane capacitance caused by structurally dissimilar lipophilic anions. | 2008 Jan |
|
| Positive patch-test reactions to mixed dialkyl thioureas: cross-sectional data from the North American Contact Dermatitis Group, 1994 to 2004. | 2008 Jul-Aug |
|
| The oxidative degradation of 2-mercaptobenzothiazole at the interface of beta-MnO2 and water. | 2008 Jun 15 |
|
| Simultaneous square wave voltammetric determination of 2-mercaptobenzothiazole and 2-mercaptobenzoxazole by partial least squares method in water samples. | 2008 Mar 1 |
|
| Photodegradation of 2-mercaptobenzothiazole in the gamma-Fe(2)O(3)/oxalate suspension under UVA light irradiation. | 2008 May 1 |
|
| North American Contact Dermatitis Group patch-test results, 2003-2004 study period. | 2008 May-Jun |
|
| Reactivity of in vitro activated human T lymphocytes to p-phenylenediamine and related substances. | 2008 Oct |
|
| Bladder cancer risks in workers manufacturing chemicals for the rubber industry. | 2008 Oct |
|
| Re-creation of historical chrysotile-containing joint compounds. | 2008 Sep |
|
| Synthesis, characterization, and biological studies of organotin(IV) derivatives with o- or p-hydroxybenzoic acids. | 2009 |
|
| A polynuclear d10-d10 metal complex with unusual near-infrared luminescence and high thermal stability. | 2009 Apr 6 |
|
| Rhenium(I) tricarbonyl complexes with poly(azolyl)borates generated in situ from an organometallic precursor containing the B-H...Re coordination motif. | 2009 May 4 |
Patents
Sample Use Guides
only for animals: Apply generously to affected areas once or twice daily. Rub into skin with fingertips.
Route of Administration:
Topical
| Substance Class |
Chemical
Created
by
admin
on
Edited
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by
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on
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| Record UNII |
5RLR54Z22K
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| Record Status |
Validated (UNII)
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| Record Version |
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Code | English | ||
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| Classification Tree | Code System | Code | ||
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EPA PESTICIDE CODE |
51701
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NDF-RT |
N0000185508
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CFR |
21 CFR 524.1376
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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DB11496
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m7205
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PRIMARY | Merck Index | ||
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1358845
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PRIMARY | RxNorm | ||
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C45678
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CONCEPT | Industrial Aid | ||
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4025
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697993
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2041
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21 CFR 176.300
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34292
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5RLR54Z22K
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100000076525
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N0000175629
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PRIMARY | Increased Histamine Release [PE] | ||
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DTXSID1020807
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Mercaptobenzothiazole
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C005563
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205-736-8
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C83512
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149-30-4
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N0000184306
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PRIMARY | Cell-mediated Immunity [PE] | ||
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SUB14518MIG
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5RLR54Z22K
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N0000171131
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PRIMARY | Allergens [Chemical/Ingredient] |
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SALT/SOLVATE -> PARENT |
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
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