MONOCROTOPHOS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H14NO5P
Molecular Weight	223.1635
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC(=O)\C=C(/C)OP(=O)(OC)OC

InChI

InChIKey=KRTSDMXIXPKRQR-AATRIKPKSA-N

InChI=1S/C7H14NO5P/c1-6(5-7(9)8-2)13-14(10,11-3)12-4/h5H,1-4H3,(H,8,9)/b6-5+

HIDE SMILES / InChI

Molecular Formula	C7H14NO5P
Molecular Weight	223.1635
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Inhibition of interleukin 2 driven proliferation of mouse CTLL2 cells, by selected carbamate and organophosphate insecticides and congeners of carbaryl.	1993 Mar-Jun	8349949
Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds.	1996	8783813
Serotonin and benzylamine oxidation by type A and type B MAO of rat brain in presence of organophosphate pesticides.	2001 Aug	12018584
Effects of organophosphorous pesticides used in china on various mammalian cells.	2005	15793557
Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos.	2005 Feb	15679473
The "intermediate syndrome" as critical sequelae of organophosphate poisoning: the first report of two cases in Thailand.	2005 Sep	16536121
Effect of pesticide residues on health and different enzyme levels in the blood of farm workers from Gadap (rural area) Karachi-Pakistan.	2006 Sep	16487989
Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carbamate insecticides.	2007 Feb	17546082
Comparison of pesticide sensitivity by electrochemical test based on acetylcholinesterase biosensor.	2007 Sep 30	17590326
A comparative study on the relationship between various toxicological endpoints in Caenorhabditis elegans exposed to organophosphorus insecticides.	2008	18569613
Estrogenic effects of monocrotophos evaluated by vitellogenin mRNA and protein induction in male goldfish (Carassius auratus).	2009 Aug	19439194
Impaired mitochondrial functions in organophosphate induced delayed neuropathy in rats.	2009 Dec	19517227
Effects of combined exposure to dichlorvos and monocrotophos on blood and brain biochemical variables in rats.	2010 Feb	20026515
Effects of monocrotophos on the reproductive axis in the female goldfish (Carassius auratus).	2010 Jun	20298809
Effects of monocrotophos on the reproductive axis in the male goldfish (Carassius auratus): potential mechanisms underlying vitellogenin induction.	2010 Jun 1	20149464
Caspase cascade regulated mitochondria mediated apoptosis in monocrotophos exposed PC12 cells.	2010 Nov 15	20957986
Monocrotophos toxicity and bioenergetics of muscle weakness in the rat.	2010 Nov 9	20728503
Esterase metabolism of cholinesterase inhibitors using rat liver in vitro.	2011 Mar 15	21237238
Monocrotophos induced apoptosis in PC12 cells: role of xenobiotic metabolizing cytochrome P450s.	2011 Mar 21	21445290
Concomitant exposure to arsenic and organophosphates on tissue oxidative stress in rats.	2011 May	21349312
Augmentation of hepatic and renal oxidative stress and disrupted glucose homeostasis by monocrotophos in streptozotocin-induced diabetic rats.	2011 Sep 30	21821013
Increased oxidative stress is associated with the development of organophosphate-induced delayed neuropathy.	2012 Dec	22751200
Monocrotophos induced oxidative damage associates with severe acetylcholinesterase inhibition in rat brain.	2012 Mar	22285544
Insights into the mechanisms mediating hyperglycemic and stressogenic outcomes in rats treated with monocrotophos, an organophosphorus insecticide.	2012 Mar 29	22305719
The effect of acute severe monocrotophos poisoning on inhibition, expression and activity of acetylcholinesterase in different rat brain regions.	2012 Oct	22903060
Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells.	2012 Oct	22733800
Trans-resveratrol restores the damages induced by organophosphate pesticide-monocrotophos in neuronal cells.	2013 Jan	23833438
Prolonged monocrotophos intake induces cardiac oxidative stress and myocardial damage in rats.	2013 May 10	23228476
Organophosphate pesticides-induced changes in the redox status of rat tissues and protective effects of antioxidant vitamins.	2015 Apr	24248738
Effects of monocrotophos pesticide on steroidogenesis and transcription of steroidogenic enzymes in rainbow trout RTG-2 cells involving the protein kinase A signal pathway.	2015 Feb	25317747

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:10:32 UTC 2023` Edited by `admin` on `Fri Dec 15 15:10:32 UTC 2023`
Record UNII	5Q3PE07Z18
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MONOCROTOPHOS

Common Name

English

MONOCIL

Brand Name

English

KADETT

Brand Name

English

DIMETHYL (1E)-1-METHYL-3-(METHYLAMINO)-3-OXO-1-PROPENYL PHOSPHATE

Systematic Name

English

AZODRIN

Brand Name

English

MONOCRON

Brand Name

English

MONOCROTOPHOS [ISO]

Common Name

English

NUVACRON

Brand Name

English

DIMETHYL (E)-1-METHYL-2-(METHYLCARBAMOYL)VINYL PHOSPHATE

Systematic Name

English

MONOCROTOPHOS [MI]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

58901