TALOPRAM

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H25NO
Molecular Weight	295.4186
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNCCCC1(OC(C)(C)C2=C1C=CC=C2)C3=CC=CC=C3

InChI

InChIKey=LJBBMCNHIUJBDU-UHFFFAOYSA-N

InChI=1S/C20H25NO/c1-19(2)17-12-7-8-13-18(17)20(22-19,14-9-15-21-3)16-10-5-4-6-11-16/h4-8,10-13,21H,9,14-15H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C20H25NO
Molecular Weight	295.4186
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5768100 | https://www.ncbi.nlm.nih.gov/pubmed/4165059

Talopram (Lu 3-010) is a selective inhibitor norepinephrine transporter belonging to the antidepressants of the thymoleptic group.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Norepinephrine transporter 191 Target ID: CHEMBL222 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21730142 \| https://www.ncbi.nlm.nih.gov/pubmed/5768100	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Depression 235 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5796678 https://www.ncbi.nlm.nih.gov/pubmed/4912084	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Pharmacological studies of a new series of bicyclic thymoleptics.	1966	4165059
Tonic immobility in guinea pigs: a behavioural response for detecting an anxiolytic-like effect?	2002 Jul	12218506
Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter.	2004 Aug	15246361
PET imaging of norepinephrine transporters.	2006	17073682
Synthesis and positron emission tomography evaluation of three norepinephrine transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram.	2006 Jan-Feb	16322935
From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies.	2008 May 22	18429609

Patents

Sample Use Guides

In Vivo Use Guide

rodents: 12.5-50 mg/kg i.p.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:26:14 GMT 2023` Edited by `admin` on `Sat Dec 16 05:26:14 GMT 2023`
Record UNII	5PY881HC79
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TALOPRAM

Official Name

English

N,3,3-TRIMETHYL-1-PHENYL-1-PHTHALANPROPYLAMINE

Common Name

English

talopram [INN]

Common Name

English

1-ISOBENZOFURANPROPANAMINE, 1,3-DIHYDRO-N,3,3-TRIMETHYL-1-PHENYL-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29747