U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C4H6O2S
Molecular Weight 118.154
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VINYL SULFONE

SMILES

C=CS(=O)(=O)C=C

InChI

InChIKey=AFOSIXZFDONLBT-UHFFFAOYSA-N
InChI=1S/C4H6O2S/c1-3-7(5,6)4-2/h3-4H,1-2H2

HIDE SMILES / InChI

Molecular Formula C4H6O2S
Molecular Weight 118.154
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Fasciola gigantica: evaluation of the effect of phenyl vinyl sulfone in vitro.
2008-05
"Click" synthesis of small-molecule inhibitors targeting caspases.
2008-03-07
Laccase immobilization on the tailored cellulose-based Granocel carriers.
2008-03-01
Vinyl sulfones.
2008-03
Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.
2008-02-28
Interaction of pepsin with aromatic amino acids and their derivatives immobilized to Sepharose.
2008-02-15
Carbon nanotubes as structural nanofibers for hyaluronic acid hydrogel scaffolds.
2008-02
Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes.
2008-01-15
Application and properties of butyl acrylate/pentaerythrite triacrylate copolymers and cellulose-based Granocel as carriers for trypsin immobilization.
2008-01-15
Fabrication and characterization of cross-linkable hydrogel particles based on hyaluronic acid: potential application in vocal fold regeneration.
2008
Dipeptidyl alpha-fluorovinyl Michael acceptors: synthesis and activity against cysteine proteases.
2007-12-01
Tandem conjugate addition-elimination for the diastereoselective synthesis of 4E-alkenyl syn-1,3-diols.
2007-10-11
Michael acceptors as cysteine protease inhibitors.
2007-10
Release of model proteins and basic fibroblast growth factor from in situ forming degradable dextran hydrogels.
2007-09-11
Diastereoselective C-C bond formation at C-5 of vinyl sulfone-modified hex-5-enofuranosyl carbohydrates: diversity-oriented synthesis of branched-chain sugars and beyond.
2007-07-20
A smart membrane based on an antigen-responsive hydrogel.
2007-07-01
Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model.
2007-07
Evaluation of man-tailored cellulose-based carriers in glucoamylase immobilization.
2007-06-11
The vinyl-sulfonium bond in human myeloperoxidase: impact on compound I formation and reduction by halides and thiocyanate.
2007-05-04
Rapidly in situ-forming degradable hydrogels from dextran thiols through Michael addition.
2007-05
Activity-based fingerprinting and inhibitor discovery of cysteine proteases in a microarray.
2007-04-21
Effects of gamma-irradiation on physical and biologic properties of crosslinked hyaluronan tissue engineering scaffolds.
2007-03
Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor.
2007-01
Use of hyaluronic acid fillers for the treatment of the aging face.
2007
A highly selective synthesis of dialkenyl sulfones via cross-metathesis of divinyl sulfone.
2006-12-07
3,3'-bimorpholine derivatives as a new class of organocatalysts for asymmetric Michael addition.
2006-06-08
Enantioselective construction of quaternary carbon centre catalysed by bifunctional organocatalyst.
2006-06-07
Physical matrices stabilized by enzymatically sensitive covalent crosslinks.
2006-05
Cobalt-catalyzed reductive coupling of saturated alkyl halides with activated alkenes.
2006-01-20
Three-dimensional domain-swapped oligomers of ribonuclease A: identification of a fifth tetramer, pentamers and hexamers, and detection of trace heptameric, octameric and nonameric species.
2006-01
Reuse of reactive dyes for dyeing of jute fabric.
2006-01
Principles of soft tissue augmentation for the aging face.
2006
Functional inhibition of NF-kappaB signal transduction in alphavbeta3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IkappaB gene.
2006
Inhibitors of cysteine proteases.
2006
Synthesis and evaluation of hydrolyzable hyaluronan-tethered bupivacaine delivery systems.
2005-11-17
Novel synthesis of 2-aryl and 2,3-disubstituted indoles by modified double elimination protocol.
2005-10-13
A diastereoselective and general route to 5-amino-5-deoxysugars: influence of C-3 substitution on the addition of amines to C-5 of vinyl sulfone-modified hex-5-enofuranosyl carbohydrates.
2005-09-30
Zn/CuI-mediated coupling of alkyl halides with vinyl sulfones, vinyl sulfonates, and vinyl sulfonamides.
2005-08-19
Response of intestinal cells and macrophages to an orally administered cellulose-PEG based polymer as a potential treatment for intractable edemas.
2005-07
Effect of shear on intramolecular and intermolecular association during cross-linking of hydroxyethylcellulose in dilute aqueous solutions.
2005-06-30
Kinetics of degradation of sulphur mustard on impregnated carbons.
2005-05-20
Recombinant protein-co-PEG networks as cell-adhesive and proteolytically degradable hydrogel matrixes. Part I: Development and physicochemical characteristics.
2005-05-10
Thiophilic paramagnetic particles as a batch separation medium for the purification of antibodies from various source materials.
2005-03-15
Screening for selective small molecule inhibitors of the proteasome using activity-based probes.
2005
Reactions of sulphur mustard on impregnated carbons.
2004-12-31
Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach.
2004-11-29
Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases.
2004-10-01
Mercaptoheterocyclic ligands grafted on a poly(ethylene vinyl alcohol) membrane for the purification of immunoglobulin G in a salt independent thiophilic chromatography.
2004-08-25
Divinyl sulfone as a postdigestion modifier for enhancing the a(1) Ion in MS/MS and postsource decay: potential applications in proteomics.
2004-07-15
Anti-inflammatory drug delivery from hyaluronic acid hydrogels.
2004
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:35:07 GMT 2025
Edited
by admin
on Mon Mar 31 18:35:07 GMT 2025
Record UNII
5PFN71LP8M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VINYL SULFONE
HSDB  
Systematic Name English
NSC-133793
Preferred Name English
VINYL SULFONE [HSDB]
Common Name English
NSC-57304
Code English
ETHENYLSULFONYLETHENE
Systematic Name English
VINYL SULPHONE
Systematic Name English
VINYLSULFONYLETHENE
Systematic Name English
1-VINYLSULFONYLETHYLENE
Systematic Name English
DIVINYL SULFONE
Systematic Name English
BIS(ETHENYL)SULFONE
Systematic Name English
ETHENE, 1,1'-SULFONYLBIS-
Systematic Name English
NSC-18590
Code English
Code System Code Type Description
CHEBI
53729
Created by admin on Mon Mar 31 18:35:07 GMT 2025 , Edited by admin on Mon Mar 31 18:35:07 GMT 2025
PRIMARY
EPA CompTox
DTXSID6031253
Created by admin on Mon Mar 31 18:35:07 GMT 2025 , Edited by admin on Mon Mar 31 18:35:07 GMT 2025
PRIMARY
PUBCHEM
6496
Created by admin on Mon Mar 31 18:35:07 GMT 2025 , Edited by admin on Mon Mar 31 18:35:07 GMT 2025
PRIMARY
CAS
77-77-0
Created by admin on Mon Mar 31 18:35:07 GMT 2025 , Edited by admin on Mon Mar 31 18:35:07 GMT 2025
PRIMARY
NSC
18590
Created by admin on Mon Mar 31 18:35:07 GMT 2025 , Edited by admin on Mon Mar 31 18:35:07 GMT 2025
PRIMARY
NSC
57304
Created by admin on Mon Mar 31 18:35:07 GMT 2025 , Edited by admin on Mon Mar 31 18:35:07 GMT 2025
PRIMARY
NSC
133793
Created by admin on Mon Mar 31 18:35:07 GMT 2025 , Edited by admin on Mon Mar 31 18:35:07 GMT 2025
PRIMARY
FDA UNII
5PFN71LP8M
Created by admin on Mon Mar 31 18:35:07 GMT 2025 , Edited by admin on Mon Mar 31 18:35:07 GMT 2025
PRIMARY
ECHA (EC/EINECS)
201-057-6
Created by admin on Mon Mar 31 18:35:07 GMT 2025 , Edited by admin on Mon Mar 31 18:35:07 GMT 2025
PRIMARY
HSDB
2028
Created by admin on Mon Mar 31 18:35:07 GMT 2025 , Edited by admin on Mon Mar 31 18:35:07 GMT 2025
PRIMARY