DEXECADOTRIL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H23NO4S
Molecular Weight	385.477
Optical Activity	( + )
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)SC[C@H](CC1=CC=CC=C1)C(=O)NCC(=O)OCC2=CC=CC=C2

InChI

InChIKey=ODUOJXZPIYUATO-IBGZPJMESA-N

InChI=1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25)/t19-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H23NO4S
Molecular Weight	385.477
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12370063 | https://www.ncbi.nlm.nih.gov/pubmed/28477056 | DOI: 10.3390/molecules21010075

Dexecadotril is powerful and selective inhibitor of neprilysin. It is anti-hypotensive agent. Dexecadotril was found to possess chemoprotective activity. It might be biologically active against multiple myeloma. It was under clinical evaluation as an intestinal antisecretatory agent.

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

Dose: 75 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:19:07 GMT 2025` Edited by `admin` on `Mon Mar 31 18:19:07 GMT 2025`
Record UNII	5OFI9D9892
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DEXECADOTRIL

Official Name

English

(+)-N-((R)-.ALPHA.-(MERCAPTOMETHYL)HYDROCINNAMOYL)GLYCINE, BENZYL ESTER, ACETATE (ESTER)

Preferred Name

English

Retorphan

Common Name

English

dexecadotril [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C783