6-METHYLURACIL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H6N2O2
Molecular Weight	126.1133
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC(=O)NC(=O)N1

InChI

InChIKey=SHVCSCWHWMSGTE-UHFFFAOYSA-N

InChI=1S/C5H6N2O2/c1-3-2-4(8)7-5(9)6-3/h2H,1H3,(H2,6,7,8,9)

HIDE SMILES / InChI

Molecular Formula	C5H6N2O2
Molecular Weight	126.1133
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
nucleic acid metabolic process 2 Target ID: GO:0090304 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5641146	Modulator 828

PubMed

Title	Date	PubMed
Structure-activity relationship of ligands of uracil phosphoribosyltransferase from Toxoplasma gondii.	1994 Aug 17	8080452
Tetraalkylammonium derivatives of 6-methyluracil, a new class of cholinesterase inhibitors: characteristics of interaction with cholinesterases from different groups of animals.	2001 Jan-Feb	11712130
Effect of tetraalkylammonium derivative of 6-methyluracil on amplitude and temporal parameters of miniature endplate potentials in frog neuromuscular junction.	2001 May	11550049
[Morphological aspects of dermatotrophic action of methyluracil applied epicutaneously].	2002	12530313
[Studies of biological activity of mineral oil dialkyl disulfide (an experimental study)].	2002	12520911
The acidity of uracil and uracil analogs in the gas phase: four surprisingly acidic sites and biological implications.	2002 Aug	12216739
Genotoxicity study of a new tetraalkylammonium derivative of 6-methyluracil (agent No. 547).	2002 Mar	11914783
[Photophoresis of methyluracil ointment in the complex treatment of temporomandibular pain syndrome].	2002 May-Jun	12221836
[Surgical infected wound treatment in patients with severe gastrointestinal ulcer hemorrhage].	2002 Nov-Dec	12549260
[Current methods for local drug therapy of infected wounds].	2003	12645211
Antiparasitic activity of highly conjugated pyrimidine-2,4-dione derivatives.	2003 Dec	14630237
Pyrrolidino-DNA.	2003 May-Aug	14565376
Biological activity of bacterial lectins and their molecular complexes with heterocyclic bis-adducts.	2003 Sep-Oct	14723158
Effect of tetraalkylammonium derivatives of 6-methyluracil on the endplate potentials of muscles of different functional types.	2004 Nov-Dec	15717607
Electron impact mass spectral study of 1,2-di-o-(m- and p-)nitro-(bromo-)benzyl-2-thio-6-methyluracils and 1,2-di-o-(m- and p-)nitro-(bromo-)benzyl-2-thio-5-bromo-6-methyluracils.	2005	15678523
Reaction of substituted pyrimidines with photochemically generated t-BuO* radicals.	2005 Dec	16955740
Different sensitivity of miniature endplate currents of the rat extensor digitorum longus, soleus and diaphragm muscles to a novel acetylcholinesterase inhibitor C-547.	2006	16792471
[Realization of optic activatory mechanism in laser-medication impact].	2006 Mar-Apr	16752823
The design and synthesis of N-1-alkylated-5-aminoarylalkylsubstituted-6-methyluracils as potential non-nucleoside HIV-1 RT inhibitors.	2007 Dec 1	17870545
Tetrakis- and tris(1-Methyluracil) complexes of Pt(II): formation and properties of a carbon-bonded nucleobase species as well as of heternonuclear derivatives.	2007 Dec 24	18047329
[Studying the nootropic effects of betamecil].	2007 Jul-Aug	18078033
Effect of a tetraalkylammonium derivative of 6-methyluracil from a new class of acetylcholinesterase inhibitors on the endplate potential amplitude in muscles of different function types under high-frequency nerve stimulation.	2007 Jul-Aug	17929660
Selective oxidation of key functional groups in cyanotoxins during drinking water ozonation.	2007 Jun 15	17626442
Compounds with the dioxopyrimidine cycle inhibit cholinesterases from different groups of animals.	2008 Sep 25	18585370
Different sensitivity of miniature endplate currents in rat external and internal intercostal muscles to the acetylcholinesterase inhibitor C-547 as compared with diaphragm and extensor digitorum longus.	2009	19331513
An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial.	2009 Dec	19646523
Mechanisms of cardiac muscle insensitivity to a novel acetylcholinesterase inhibitor C-547.	2009 Feb	19188831
1,3-Bis(4-meth-oxy-benz-yl)-6-methyl-pyrimidine-2,4(1H,3H)-dione.	2010 Jun 30	21588055

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:19:29 GMT 2023` Edited by `admin` on `Fri Dec 15 17:19:29 GMT 2023`
Record UNII	5O052W0G6I
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

6-METHYLURACIL

Systematic Name

English

4-METHYLURACIL

Common Name

English

Methyluracil [WHO-DD]

Common Name

English

6-METHYLURACIL [MI]

Common Name

English

METHYLURACIL

Systematic Name

English

NSC-9456

Code

English

6-METHYL-2,4(1H,3H)-PYRIMIDINEDIONE

Systematic Name

English

6-METHYLURACIL [HSDB]

Common Name

English

METHYLURACIL, 4-

Common Name

English

Code System Code Type Description

PUBCHEM

12283