Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H22N4O2 |
| Molecular Weight | 278.3501 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C(NN=C1CCCCC1)C(=O)NN=C2CCCCC2
InChI
InChIKey=DSRJIHMZAQEUJV-UHFFFAOYSA-N
InChI=1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)
| Molecular Formula | C14H22N4O2 |
| Molecular Weight | 278.3501 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Developmental cuprizone exposure impairs oligodendrocyte lineages differentially in cortical and white matter tissues and suppresses glutamatergic neurogenesis signals and synaptic plasticity in the hippocampal dentate gyrus of rats. | 2016-01-01 |
|
| Cuprizone decreases intermediate and late-stage progenitor cells in hippocampal neurogenesis of rats in a framework of 28-day oral dose toxicity study. | 2015-09-15 |
|
| Developmental exposure to cuprizone reduces intermediate-stage progenitor cells and cholinergic signals in the hippocampal neurogenesis in rat offspring. | 2015-05-05 |
|
| Enhanced accumulation of Kir4.1 protein, but not mRNA, in a murine model of cuprizone-induced demyelination. | 2013-11-06 |
|
| Cuprizone neurotoxicity, copper deficiency and neurodegeneration. | 2010-09 |
|
| 17beta-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice. | 2009-06 |
|
| Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse. | 2008-12 |
|
| Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination. | 2008-06-11 |
|
| Copper and zinc dismetabolism in the mouse brain upon chronic cuprizone treatment. | 2005-07 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:48:22 GMT 2025
by
admin
on
Mon Mar 31 18:48:22 GMT 2025
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| Record UNII |
5N16U7E0AO
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| Record Status |
Validated (UNII)
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| Record Version |
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