CUPRIZONE

O=C(NN=C1CCCCC1)C(=O)NN=C2CCCCC2

InChIKey=DSRJIHMZAQEUJV-UHFFFAOYSA-N

InChI=1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
Copper and zinc dismetabolism in the mouse brain upon chronic cuprizone treatment.	2005 Jul	15971002
Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse.	2008 Dec	18938062
Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination.	2008 Jun 11	18550754
17beta-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice.	2009 Jun	19031445
Cuprizone neurotoxicity, copper deficiency and neurodegeneration.	2010 Sep	20685220
Enhanced accumulation of Kir4.1 protein, but not mRNA, in a murine model of cuprizone-induced demyelination.	2013 Nov 6	24070676
Developmental exposure to cuprizone reduces intermediate-stage progenitor cells and cholinergic signals in the hippocampal neurogenesis in rat offspring.	2015 May 5	25704630
Cuprizone decreases intermediate and late-stage progenitor cells in hippocampal neurogenesis of rats in a framework of 28-day oral dose toxicity study.	2015 Sep 15	26057786
Developmental cuprizone exposure impairs oligodendrocyte lineages differentially in cortical and white matter tissues and suppresses glutamatergic neurogenesis signals and synaptic plasticity in the hippocampal dentate gyrus of rats.	2016 Jan 1	26577399

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:34:05 GMT 2023` Edited by `admin` on `Fri Dec 15 17:34:05 GMT 2023`
Record UNII	5N16U7E0AO
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

CUPRIZONE

Common Name

English

BIS(CYCLOHEXANONE)OXALDIHYDRAZONE

Common Name

English

NSC-4283

Code

English

Code System Code Type Description

PUBCHEM

9723