Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C16H32O2.C12H26N4O6 |
Molecular Weight | 578.7821 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 10 / 10 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCCCCC(O)=O.[H][C@]2(O[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O)O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2N
InChI
InChIKey=XBJFIVWYEHFNML-SJHBPNDZSA-N
InChI=1S/C16H32O2.C12H26N4O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;13-2-5-8(18)9(19)6(16)12(21-5)22-11-4(15)1-3(14)7(17)10(11)20/h2-15H2,1H3,(H,17,18);3-12,17-20H,1-2,13-16H2/t;3-,4+,5-,6-,7+,8-,9-,10-,11-,12-/m.1/s1
Molecular Formula | C16H32O2 |
Molecular Weight | 256.4241 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C12H26N4O6 |
Molecular Weight | 322.358 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 10 / 10 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Study of aminoglycoside-nucleic acid interactions by an HPLC method. | 2001 Apr 23 |
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An efficient synthesis of mimetics of neamine for RNA recognition. | 2001 May 31 |
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Design of novel antibiotics that bind to the ribosomal acyltransfer site. | 2002 Apr 3 |
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Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site. | 2002 Jun |
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Neamine inhibits xenografic human tumor growth and angiogenesis in athymic mice. | 2005 Dec 15 |
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Neamine derivatives having a nucleobase with a lysine or an arginine as a linker, their synthesis and evaluation as potential inhibitors for HIV TAR-Tat. | 2006 Apr 15 |
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Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site. | 2006 Feb |
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Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides. | 2006 Jul |
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Cationic polyamines inhibit anthrax lethal factor protease. | 2006 Jun 8 |
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Mechanism of RNA cleavage catalyzed by sequence specific polyamide nucleic acid-neamine conjugate. | 2007 Fall |
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Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. | 2007 Feb 12 |
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Unique O-ribosylation in the biosynthesis of butirosin. | 2007 Jul 1 |
|
Design and synthesis of a structurally constrained aminoglycoside. | 2007 Jul 6 |
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Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. | 2007 Jun 1 |
|
Monitoring aminoglycoside-induced conformational changes in 16S rRNA through acrylamide quenching. | 2007 Jun 1 |
|
Fluorescent HIV-1 Dimerization Initiation Site: design, properties, and use for ligand discovery. | 2007 Mar 21 |
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Copper(II) complexes of lipophilic aminoglycoside derivatives for the amino acid enantiomeric separation by ligand-exchange liquid chromatography. | 2008 Mar 28 |
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Synthesis and evaluation of novel neamine derivatives effectively targeting to RNA. | 2009 Apr 15 |
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Aminoglycosides: molecular insights on the recognition of RNA and aminoglycoside mimics. | 2009 Apr 28 |
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Enantioseparation by MEKC using a ligand exchange-based chiral pseudostationary phase. | 2009 Aug |
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Search for novel aminoglycosides by combining fragment-based virtual screening and 3D-QSAR scoring. | 2009 Feb |
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Neamine inhibits prostate cancer growth by suppressing angiogenin-mediated rRNA transcription. | 2009 Mar 15 |
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Synthesis of neamine-derived pseudodisaccharides by stereo- and regio-selective functional group transformations. | 2009 Oct 21 |
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Mutation K42R in ribosomal protein S12 does not affect susceptibility of Mycobacterium smegmatis 16S rRNA A-site mutants to 2-deoxystreptamines. | 2010 Aug 5 |
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Neamine inhibits cell proliferation, migration, and invasion in H7402 human hepatoma cells. | 2010 Dec |
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The nebramycin aminoglycoside profiles of Streptomyces tenebrarius and their characterization using an integrated liquid chromatography-electrospray ionization-tandem mass spectrometric analysis. | 2010 Feb 19 |
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Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. | 2010 Jan 14 |
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Antibacterial activities of aminoglycoside antibiotics-derived cationic amphiphiles. Polyol-modified neomycin B-, kanamycin A-, amikacin-, and neamine-based amphiphiles with potent broad spectrum antibacterial activity. | 2010 May 13 |
|
Aminoglycoside binding to Oxytricha nova telomeric DNA. | 2010 Nov 16 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:25:24 GMT 2023
by
admin
on
Sat Dec 16 01:25:24 GMT 2023
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Record UNII |
5LPX2HRF67
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Record Status |
Validated (UNII)
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Record Version |
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-
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5LPX2HRF67
Created by
admin on Sat Dec 16 01:25:24 GMT 2023 , Edited by admin on Sat Dec 16 01:25:24 GMT 2023
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123133527
Created by
admin on Sat Dec 16 01:25:24 GMT 2023 , Edited by admin on Sat Dec 16 01:25:24 GMT 2023
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PARENT -> SALT/SOLVATE |