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Details

Stereochemistry ABSOLUTE
Molecular Formula C16H32O2.C12H26N4O6
Molecular Weight 578.7821
Optical Activity UNSPECIFIED
Defined Stereocenters 10 / 10
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NEAMINE PALMITATE

SMILES

CCCCCCCCCCCCCCCC(O)=O.[H][C@]2(O[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O)O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2N

InChI

InChIKey=XBJFIVWYEHFNML-SJHBPNDZSA-N
InChI=1S/C16H32O2.C12H26N4O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;13-2-5-8(18)9(19)6(16)12(21-5)22-11-4(15)1-3(14)7(17)10(11)20/h2-15H2,1H3,(H,17,18);3-12,17-20H,1-2,13-16H2/t;3-,4+,5-,6-,7+,8-,9-,10-,11-,12-/m.1/s1

HIDE SMILES / InChI

Molecular Formula C16H32O2
Molecular Weight 256.4241
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C12H26N4O6
Molecular Weight 322.358
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 10 / 10
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

PubMed

PubMed

TitleDatePubMed
Study of aminoglycoside-nucleic acid interactions by an HPLC method.
2001 Apr 23
An efficient synthesis of mimetics of neamine for RNA recognition.
2001 May 31
Design of novel antibiotics that bind to the ribosomal acyltransfer site.
2002 Apr 3
Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site.
2002 Jun
Neamine inhibits xenografic human tumor growth and angiogenesis in athymic mice.
2005 Dec 15
Neamine derivatives having a nucleobase with a lysine or an arginine as a linker, their synthesis and evaluation as potential inhibitors for HIV TAR-Tat.
2006 Apr 15
Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site.
2006 Feb
Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides.
2006 Jul
Cationic polyamines inhibit anthrax lethal factor protease.
2006 Jun 8
Mechanism of RNA cleavage catalyzed by sequence specific polyamide nucleic acid-neamine conjugate.
2007 Fall
Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin.
2007 Feb 12
Unique O-ribosylation in the biosynthesis of butirosin.
2007 Jul 1
Design and synthesis of a structurally constrained aminoglycoside.
2007 Jul 6
Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity.
2007 Jun 1
Monitoring aminoglycoside-induced conformational changes in 16S rRNA through acrylamide quenching.
2007 Jun 1
Fluorescent HIV-1 Dimerization Initiation Site: design, properties, and use for ligand discovery.
2007 Mar 21
Copper(II) complexes of lipophilic aminoglycoside derivatives for the amino acid enantiomeric separation by ligand-exchange liquid chromatography.
2008 Mar 28
Synthesis and evaluation of novel neamine derivatives effectively targeting to RNA.
2009 Apr 15
Aminoglycosides: molecular insights on the recognition of RNA and aminoglycoside mimics.
2009 Apr 28
Enantioseparation by MEKC using a ligand exchange-based chiral pseudostationary phase.
2009 Aug
Search for novel aminoglycosides by combining fragment-based virtual screening and 3D-QSAR scoring.
2009 Feb
Neamine inhibits prostate cancer growth by suppressing angiogenin-mediated rRNA transcription.
2009 Mar 15
Synthesis of neamine-derived pseudodisaccharides by stereo- and regio-selective functional group transformations.
2009 Oct 21
Mutation K42R in ribosomal protein S12 does not affect susceptibility of Mycobacterium smegmatis 16S rRNA A-site mutants to 2-deoxystreptamines.
2010 Aug 5
Neamine inhibits cell proliferation, migration, and invasion in H7402 human hepatoma cells.
2010 Dec
The nebramycin aminoglycoside profiles of Streptomyces tenebrarius and their characterization using an integrated liquid chromatography-electrospray ionization-tandem mass spectrometric analysis.
2010 Feb 19
Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives.
2010 Jan 14
Antibacterial activities of aminoglycoside antibiotics-derived cationic amphiphiles. Polyol-modified neomycin B-, kanamycin A-, amikacin-, and neamine-based amphiphiles with potent broad spectrum antibacterial activity.
2010 May 13
Aminoglycoside binding to Oxytricha nova telomeric DNA.
2010 Nov 16
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 01:25:24 GMT 2023
Edited
by admin
on Sat Dec 16 01:25:24 GMT 2023
Record UNII
5LPX2HRF67
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NEAMINE PALMITATE
Common Name English
NEOMYCIN A PALMITATE
Common Name English
Code System Code Type Description
FDA UNII
5LPX2HRF67
Created by admin on Sat Dec 16 01:25:24 GMT 2023 , Edited by admin on Sat Dec 16 01:25:24 GMT 2023
PRIMARY
PUBCHEM
123133527
Created by admin on Sat Dec 16 01:25:24 GMT 2023 , Edited by admin on Sat Dec 16 01:25:24 GMT 2023
PRIMARY
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