DETAJMIUM BITARTRATE ANHYDROUS

Details

Stereochemistry	EPIMERIC
Molecular Formula	C27H42N3O3.C4H5O6
Molecular Weight	605.7196
Optical Activity	UNSPECIFIED
Defined Stereocenters	12 / 13
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DETAJMIUM BITARTRATE ANHYDROUS

Structure Search

SMILES

O[C@H]([C@@H](O)C([O-])=O)C(O)=O.[H][C@]12C[C@]34[C@H](O)[C@@]1([H])[C@]5([H])C[C@@]([H])([C@]3([H])N(C)C6=C4C=CC=C6)[N@+]2(CC(O)CN(CC)CC)[C@H](O)[C@H]5CC

InChI

InChIKey=NXAWWUAMFJNVMF-MIOVOVSCSA-M

InChI=1S/C27H42N3O3.C4H6O6/c1-5-17-18-12-21-24-27(19-10-8-9-11-20(19)28(24)4)13-22(23(18)25(27)32)30(21,26(17)33)15-16(31)14-29(6-2)7-3;5-1(3(7)8)2(6)4(9)10/h8-11,16-18,21-26,31-33H,5-7,12-15H2,1-4H3;1-2,5-6H,(H,7,8)(H,9,10)/q+1;/p-1/t16?,17-,18-,21-,22-,23?,24-,25+,26+,27+,30-;1-,2-/m01/s1

HIDE SMILES / InChI

Molecular Formula	C27H42N3O3
Molecular Weight	456.6407
Charge	1
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	8 / 11
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C4H5O6
Molecular Weight	149.0789
Charge	-1
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8656646 | https://www.ncbi.nlm.nih.gov/pubmed/10420613 | https://www.ncbi.nlm.nih.gov/pubmed/439618 | https://www.ncbi.nlm.nih.gov/pubmed/6815028 | https://www.ncbi.nlm.nih.gov/pubmed/7866551 | Aronson, J.K. (2015) Meyler's Side Effects of Drugs, page 97, retrieved from: https://books.google.ru/books?id=NOKoBAAAQBAJ

Detajmium bitartrate anhydrous is Rauwolfia alkaloid. It is a sodium-channel-blocking drug with an extremely long recovery from use-dependent sodium channel block. Detajmium has antiarrhythmic properties. It caused comparable prolongations of the intraventricular conduction time during sinus rhythm and progressively broadened the QRS complex. Rauwolfia alkaloids use is restricted by serious adverse effects, such as dysrhytmias. Several detajmium bitartrate lethal intoxications were reported.

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:59:37 GMT 2023` Edited by `admin` on `Fri Dec 15 18:59:37 GMT 2023`
Record UNII	5KU1H0W7VZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DETAJMIUM BITARTRATE ANHYDROUS

Common Name

English

AJMALANIUM, 4-(3-(DIETHYLAMINO)-2-HYDROXYPROPYL)-17,21-DIHYDROXY-, (17R,21.ALPHA.)-, SALT WITH (2R,3R)-2,3-DIHYDROXYBUTANEDIOIC ACID (1:1)

Common Name

English

4-(3-(DIETHYLAMINO)-2-HYDROXYPROPYL)AJMALINIUM HYDROGEN TARTRATE

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C166851