U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 00:41:13 GMT 2023
Edited
by admin
on Sat Dec 16 00:41:13 GMT 2023
Source Materials Class ORGANISM
Source Materials Type BACTERIUM
Source Materials Parent
Part BACTERIAL CAPSULE
Fraction Material Type POLYSACCHARIDE
Fraction Name POLYSACCHARIDE
Record UNII
5JT3N61JSP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NEISSERIA MENINGITIDIS GROUP W-135 CAPSULAR OLIGOSACCHARIDE DIPHTHERIA CRM197 PROTEIN CONJUGATE ANTIGEN
Common Name English
Classification Tree Code System Code
NDF-RT N0000183895
Created by admin on Sat Dec 16 00:41:13 GMT 2023 , Edited by admin on Sat Dec 16 00:41:13 GMT 2023
Code System Code Type Description
FDA UNII
5JT3N61JSP
Created by admin on Sat Dec 16 00:41:13 GMT 2023 , Edited by admin on Sat Dec 16 00:41:13 GMT 2023
PRIMARY
NDF-RT
N0000183364
Created by admin on Sat Dec 16 00:41:13 GMT 2023 , Edited by admin on Sat Dec 16 00:41:13 GMT 2023
PRIMARY Actively Acquired Immunity [PE]
DRUG BANK
DB14429
Created by admin on Sat Dec 16 00:41:13 GMT 2023 , Edited by admin on Sat Dec 16 00:41:13 GMT 2023
PRIMARY
DAILYMED
5JT3N61JSP
Created by admin on Sat Dec 16 00:41:13 GMT 2023 , Edited by admin on Sat Dec 16 00:41:13 GMT 2023
PRIMARY
NDF-RT
N0000170916
Created by admin on Sat Dec 16 00:41:13 GMT 2023 , Edited by admin on Sat Dec 16 00:41:13 GMT 2023
PRIMARY Vaccines, Inactivated [Chemical/Ingredient]
NDF-RT
N0000170889
Created by admin on Sat Dec 16 00:41:13 GMT 2023 , Edited by admin on Sat Dec 16 00:41:13 GMT 2023
PRIMARY Meningococcal Vaccines [Chemical/Ingredient]
Related Record Type Details
TARGET ORGANISM->VACCINE ANTIGEN

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
CONJUGATION CONJUGATION CONJUGATING AGENT ADIPIC ACID BIS(N-HYDROXYSUCCINIMIDE) ESTER W98WEU25G4
REDUCTION REDUCE END GROUPS REDUCING AGENT SODIUM BOROHYDRIDE 87L0B9CPPA
ACTIVATION FOR REDUCTIVE AMINATION ACTIVATION FOR REDUCTIVE AMINATION AMINATION AMMONIUM ACETATE RRE756S6Q2
CONJUGATION CONJUGATION PROTEIN CONJUGATE CORYNEBACTERIUM DIPHTHERIAE CRM197 PROTEIN 08VC9WC084
PARTIAL HYDROLYSIS DEPOLYMERIZATION Acetic acid Q40Q9N063P

Physical Modifications

Modification Role Parameter Name Amount
MOLECULAR SIZING SIZING

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
PROTEIN CONJUGATION CORYNEBACTERIUM DIPHTHERIAE CRM197 PROTEIN 08VC9WC084
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:WEIGHT AVERAGE CHEMICAL
POLYSACCHARIDE TO PROTEIN RATIO CHEMICAL