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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H32O5
Molecular Weight 364.4766
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TETRAHYDROCORTISONE

SMILES

C[C@@]12CC[C@]([H])(C[C@@]2([H])CC[C@@]3([H])[C@]4([H])CC[C@](C(=O)CO)([C@@]4(C)CC(=O)[C@@]31[H])O)O

InChI

InChIKey=SYGWGHVTLUBCEM-ZIZPXRJBSA-N
InChI=1S/C21H32O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,18,22-23,26H,3-11H2,1-2H3/t12-,13-,14+,15+,18-,19+,20+,21+/m1/s1

HIDE SMILES / InChI

Molecular Formula C21H32O5
Molecular Weight 364.4766
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 8 / 8
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

PubMed

PubMed

TitleDatePubMed
Increased cortisol metabolites and reduced activity of 11beta-hydroxysteroid dehydrogenase in patients on hemodialysis.
2002 May
Modulation of renal calcium handling by 11 beta-hydroxysteroid dehydrogenase type 2.
2002 Oct
11beta-Hydroxysteroid dehydrogenase type 2 activity is associated with left ventricular mass in essential hypertension.
2005 Mar
[The urinary index of intracellular glucocorticoid reactivation--a novel marker of metabolic syndrome and type 2 diabetes].
2006 Dec 28
Comprehensive study of urinary cortisol metabolites in hyperthyroid and hypothyroid patients.
2006 Jan
Direct determination of the ratio of tetrahydrocortisol+allo-tetrahydrocortisol to tetrahydrocortisone in urine by LC-MS-MS.
2006 Jan 18
RP-HPLC method with fluorescence detection for determination of small quantities of triamcinolone in plasma in presence of endogenous steroids after derivatization with 9-anthroyl nitrile; pharmacokinetic studies.
2006 Jul 24
Sex-specific difference in the interconversion of cortisol and cortisone in men and women.
2007 Apr
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.
2007 Mar
Simultaneous measurements of urinary free cortisol and cortisone for the assessment of functional glucocorticoid activity.
2007 Oct
Simultaneous determination of tetrahydrocortisol, allotetrahydrocortisol and tetrahydrocortisone in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry.
2008 Aug
Daily urinary free cortisol and cortisone excretion is associated with urine volume in healthy children.
2008 Dec 22
Development of a liquid chromatography-tandem mass spectrometry method for the determination of 23 endogenous steroids in small quantities of primate urine.
2008 Feb 1
Diagnosis of diseases of steroid hormone production, metabolism and action.
2009
Cortisol metabolism in depressed patients and healthy controls.
2009
Effect of apolipoprotein a-I complex with tetrahydrocortisone on protein biosynthesis and glucose absorption by rat hepatocytes.
2009 Aug
Simultaneous determination of twelve tetrahydrocorticosteroid glucuronides in human urine by liquid chromatography/electrospray ionization-linear ion trap mass spectrometry.
2009 Dec 15
Urinary steroid profile after the completion of concentric and concentric/eccentric trials with the same total workload.
2009 Jun
Heritable forms of hypertension.
2009 Oct
Determination of endocrine disrupting compounds using temperature-dependent inclusion chromatography: I. Optimization of separation protocol.
2009 Oct 30
Application of hyphenated mass spectrometry techniques for the analysis of urinary free glucocorticoids.
2009 Sep
Steroid assays in paediatric endocrinology.
2010
Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS).
2010 Aug
The effect of high level tennis matches on urine steroid profiles in professional tennis players.
2010 Dec
11β-Hydroxysteroid dehydrogenase type-2 and type-1 (11β-HSD2 and 11β-HSD1) and 5β-reductase activities in the pathogenia of essential hypertension.
2010 Feb
HPLC method for determination of fluorescence derivatives of cortisol, cortisone and their tetrahydro- and allo-tetrahydro-metabolites in biological fluids.
2010 Feb 1
Altered urinary profiles of endogenous steroids in postmenopausal women with adenocarcinoma endometrii.
2010 Jan
Potential corticoid metabolites: chemical synthesis of 3- and 21-monosulfates and their double-conjugates of tetrahydrocorticosteroids in the 5alpha- and 5beta-series.
2010 Mar
Intense physical exercise increases systemic 11beta-hydroxysteroid dehydrogenase type 1 activity in healthy adult subjects.
2010 Mar
Substance Class Chemical
Created
by admin
on Sat Jun 26 02:56:11 UTC 2021
Edited
by admin
on Sat Jun 26 02:56:11 UTC 2021
Record UNII
5HF9TM2D15
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TETRAHYDROCORTISONE
MI  
Common Name English
TETRAHYDROCORTISONE [MI]
Common Name English
UROCORTISONE
Common Name English
NSC-76984
Code English
Classification Tree Code System Code
LOINC 82894-7
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82895-4
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82851-7
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 73894-8
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82896-2
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82878-0
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82901-0
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82879-8
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82849-1
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82848-3
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82857-4
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82862-4
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82855-8
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82900-2
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82899-6
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82854-1
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 81795-7
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82856-6
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82861-6
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82898-8
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 73893-0
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82850-9
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
LOINC 82897-0
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
Code System Code Type Description
WIKIPEDIA
TETRAHYDROCORTISONE
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
PRIMARY
MERCK INDEX
M10625
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
PRIMARY Merck Index
PUBCHEM
5866
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
PRIMARY
FDA UNII
5HF9TM2D15
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-161-9
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
PRIMARY
CAS
53-05-4
Created by admin on Sat Jun 26 02:56:11 UTC 2021 , Edited by admin on Sat Jun 26 02:56:11 UTC 2021
PRIMARY
Related Record Type Details
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