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Details

Stereochemistry UNKNOWN
Molecular Formula C18H22N2O2S
Molecular Weight 330.444
Optical Activity ( - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXOMEMAZINE, (-)-

SMILES

CC(CN(C)C)CN1C2=CC=CC=C2S(=O)(=O)C3=CC=CC=C13

InChI

InChIKey=QTQPVLDZQVPLGV-UHFFFAOYSA-N
InChI=1S/C18H22N2O2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)23(21,22)18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C18H22N2O2S
Molecular Weight 330.444
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Oxomemazine is a histamine H₁-receptor antagonist. Additionally, oxomemazine could be classified as a ligand for M1 receptors. It is used in the symptomatic treatment of non-productive coughs that occur specifically at night.

Approval Year

PubMed

PubMed

TitleDatePubMed
[Comparative study of two antitussive drugs in the treatment of acute dry cough of infectious origin (prospective, randomized, single blind study)].
2002 Sep-Oct
Extractive spectrophotometric methods for the determination of oxomemazine hydrochloride in bulk and pharmaceutical formulations using bromocresol green, bromocresol purple and bromophenol blue.
2005 Apr
Preliminary studies on phenothiazine-mediated reversal of multidrug resistance in mouse lymphoma and COLO 320 cells.
2005 Nov-Dec
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec

Sample Use Guides

Oxomemazine 0.33 mg/ml syrup. Suitable for adults and children over 40 kg (from the age of 12 years old). 10 ml 4 times per day. For children: The daily dose according to a child’s weight (1ml of syrup per kg per day): · Child between 13-20 kg (between 2-6 years old): 5ml 2-3 times per day. · Child between 20-30 kg (between 6-10 years old): 10 ml 2-3 times per day. · Child between 30-40 kg (between 10-12 years old): 10 ml 3-4 times a day. Repeat if necessary minimum every 4 hours. Due to the sedative effect of oxomemazine it is advisable to take this medication in the evening.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:24:57 GMT 2023
Edited
by admin
on Sat Dec 16 10:24:57 GMT 2023
Record UNII
5GP9538P4S
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OXOMEMAZINE, (-)-
Common Name English
10H-PHENOTHIAZINE-10-PROPANAMINE, N,N,.BETA.-TRIMETHYL-, 5,5-DIOXIDE, (-)-
Systematic Name English
(-)-OXOMEMAZINE
Common Name English
Code System Code Type Description
FDA UNII
5GP9538P4S
Created by admin on Sat Dec 16 10:24:57 GMT 2023 , Edited by admin on Sat Dec 16 10:24:57 GMT 2023
PRIMARY
CAS
174508-14-6
Created by admin on Sat Dec 16 10:24:57 GMT 2023 , Edited by admin on Sat Dec 16 10:24:57 GMT 2023
PRIMARY
Related Record Type Details
RACEMATE -> ENANTIOMER
ENANTIOMER -> ENANTIOMER