Lasmecabtagene Timgedleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 13:56:01 GMT 2025` Edited by `admin` on `Wed Apr 02 13:56:01 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	ALLOGENIC HUMAN
Source Materials State	LIVE
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cell
Fraction Name	t cells
Record UNII	5GP3N2YX96
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

allogeneic T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis of healthy donors, transduced with a selfinactivating, non-replicating lentiviral vector encoding a depletion ligand and a chimeric antigen receptor (CAR) targetin

Preferred Name

English

Lasmecabtagene Timgedleucel

Official Name

English

lasmecabtagene timgedleucel [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C211698

Created by admin on Wed Apr 02 13:56:01 GMT 2025 , Edited by admin on Wed Apr 02 13:56:01 GMT 2025

PRIMARY

INN

13170

Created by admin on Wed Apr 02 13:56:01 GMT 2025 , Edited by admin on Wed Apr 02 13:56:01 GMT 2025

PRIMARY

FDA UNII

5GP3N2YX96

Created by admin on Wed Apr 02 13:56:01 GMT 2025 , Edited by admin on Wed Apr 02 13:56:01 GMT 2025

PRIMARY

Related Record Type Details


					RCH7C9TW12

B-CELL RECEPTOR CD22

TARGET->CYTOTOXIC T-CELL

Comments:

CD22+ B-cell acute lymphoblastic leukemia (B-ALL)

Interaction Type:

IN-VIVO

Amount:

Related Record Type Details


					5GP3N2YX96

Lasmecabtagene Timgedleucel

ACTIVE MOIETY

Interaction Type:

IN-VIVO

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
TRANSESTERIFICATION		LENTIVIRAL TRANSFECTION		Lasmecabtagene timgedleucel lentiviral vector	8P4782A3C7
	ACTIVATOR	CELL SEPARATION		ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M

Structural Modifications

Modification Type	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN	RQR8	VE78CL7WYM
PROTEIN NOT EXPRESSED (GENE DISRUPTION)	HUMAN T-CELL ALPHA/BETA RECEPTOR	8OO8E2BVQ4
PROTEIN NOT EXPRESSED (GENE DISRUPTION)	T CELL RECEPTOR ALPHA CHAIN CONSTANT	782D7EP5JS
VECTOR EXPRESSED PROTEIN	Lasmecabtagene timgedleucel chimeric antigen receptor (CAR) targeting CD22	T6YAE69V4Z

Name	Property Type	Referenced Substance
ANTIGEN EXPRESSED	BIOLOGICAL	`8OYI5QX0HL` T-CELL SURFACE GLYCOPROTEIN CD4
ANTIGEN EXPRESSED	BIOLOGICAL	`2946IE3VYD` CD8
ANTIGEN EXPRESSED	BIOLOGICAL	`80A297KX6N` CAMPATH-1 ANTIGEN