Zifcasiran

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 15:42:14 GMT 2023` Edited by `admin` on `Sat Dec 16 15:42:14 GMT 2023`
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	5G6HL9K2G4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Zifcasiran

Official Name

English

ADS-007

Code

English

zifcasiran [INN]

Common Name

English

ZIFCASIRAN [USAN]

Common Name

English

RNA, (CM-SP-AM-AM-CM-GM-UM-AM-AM-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)G-(2'-DEOXY-2'-FLUORO)A-UM-UM-(2'-O-((1-(2-(2-(2-(2-(2-FLUORO-4-((1R)-3-HYDROXY-3-OXO-1-(2-OXO-3-(3-(5,6,7,8-TETRAHYDRO-1,8-NAPHTHYRIDIN-2-YL)PROPYL)-1-IMIDAZOLIDINYL)PROPYL)PHENO

Common Name

English

ARO HIF2 [WHO-DD]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C170918

Created by admin on Sat Dec 16 15:42:14 GMT 2023 , Edited by admin on Sat Dec 16 15:42:14 GMT 2023

PRIMARY

FDA UNII

5G6HL9K2G4

Created by admin on Sat Dec 16 15:42:14 GMT 2023 , Edited by admin on Sat Dec 16 15:42:14 GMT 2023

PRIMARY

CAS

2437257-11-7

Created by admin on Sat Dec 16 15:42:14 GMT 2023 , Edited by admin on Sat Dec 16 15:42:14 GMT 2023

PRIMARY

USAN

JK-38

Created by admin on Sat Dec 16 15:42:14 GMT 2023 , Edited by admin on Sat Dec 16 15:42:14 GMT 2023

PRIMARY

INN

12163

Created by admin on Sat Dec 16 15:42:14 GMT 2023 , Edited by admin on Sat Dec 16 15:42:14 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1-1_8;1_12-1_21;2_1;2_3;2_5;2_7;2_9;2_11;2_13;2_15;2_17;2_19;2_21	29 / 42
2'-Fluoro-Ribose	1_9-1_11;2_2;2_4;2_6;2_8;2_10;2_12;2_14;2_16;2_18;2_20	13 / 42

Linkage	Site Range	Site Count
Phosphate	1_3-1_21;2_5-2_20	35 / 40
Phosporothioate	1_2;2_2-2_4;2_21	5 / 40

Related Record Type Details


					5G6HL9K2G4

ACTIVE MOIETY

Amount: