U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 15:42:14 GMT 2023
Edited
by admin
on Sat Dec 16 15:42:14 GMT 2023
Nucleic Acid Type OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type COMPLETE
Record UNII
5G6HL9K2G4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Zifcasiran
INN   USAN  
Official Name English
ADS-007
Code English
zifcasiran [INN]
Common Name English
ZIFCASIRAN [USAN]
Common Name English
RNA, (CM-SP-AM-AM-CM-GM-UM-AM-AM-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)G-(2'-DEOXY-2'-FLUORO)A-UM-UM-(2'-O-((1-(2-(2-(2-(2-(2-FLUORO-4-((1R)-3-HYDROXY-3-OXO-1-(2-OXO-3-(3-(5,6,7,8-TETRAHYDRO-1,8-NAPHTHYRIDIN-2-YL)PROPYL)-1-IMIDAZOLIDINYL)PROPYL)PHENO
Common Name English
ARO HIF2 [WHO-DD]
Common Name English
Code System Code Type Description
NCI_THESAURUS
C170918
Created by admin on Sat Dec 16 15:42:14 GMT 2023 , Edited by admin on Sat Dec 16 15:42:14 GMT 2023
PRIMARY
FDA UNII
5G6HL9K2G4
Created by admin on Sat Dec 16 15:42:14 GMT 2023 , Edited by admin on Sat Dec 16 15:42:14 GMT 2023
PRIMARY
CAS
2437257-11-7
Created by admin on Sat Dec 16 15:42:14 GMT 2023 , Edited by admin on Sat Dec 16 15:42:14 GMT 2023
PRIMARY
USAN
JK-38
Created by admin on Sat Dec 16 15:42:14 GMT 2023 , Edited by admin on Sat Dec 16 15:42:14 GMT 2023
PRIMARY
INN
12163
Created by admin on Sat Dec 16 15:42:14 GMT 2023 , Edited by admin on Sat Dec 16 15:42:14 GMT 2023
PRIMARY
Sugar Site Range Site Count
2'-O-Methyl-Ribose 1_1-1_8;1_12-1_21;2_1;2_3;2_5;2_7;2_9;2_11;2_13;2_15;2_17;2_19;2_21 29 / 42
2'-Fluoro-Ribose 1_9-1_11;2_2;2_4;2_6;2_8;2_10;2_12;2_14;2_16;2_18;2_20 13 / 42
Linkage Site Range Site Count
Phosphate 1_3-1_21;2_5-2_20 35 / 40
Phosporothioate 1_2;2_2-2_4;2_21 5 / 40
Related Record Type Details
ACTIVE MOIETY