TOMINERSEN SODIUM

Investigational

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Tue Apr 01 23:31:01 GMT 2025` Edited by `admin` on `Tue Apr 01 23:31:01 GMT 2025`
Nucleic Acid Type	DNA
Sequence Type	COMPLETE
Record UNII	5EO3CIJ3H7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TOMINERSEN SODIUM

Common Name

English

ISIS-443139

Preferred Name

English

TOMINERSEN SODIUM [JAN]

Common Name

English

DNA, D((2'-O-(2-METHOXYETHYL))M5RC-SP-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-SP-T-SP-A-SP-A-SP-M5C-SP-A-SP-T-SP-T-SP-G-SP-A-SP-M5C-SP-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))M5

Systematic Name

English

Code System Code Type Description

FDA UNII

5EO3CIJ3H7

Created by admin on Tue Apr 01 23:31:01 GMT 2025 , Edited by admin on Tue Apr 01 23:31:01 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_6-1_15	10 / 20
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_1;1_5-1_16;1_19	14 / 19
	1_2-1_4;1_17-1_18	5 / 19

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Amount:

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ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_1] [1_3] [1_17] [1_18] [1_20]	SITE_SPECIFIC	2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE	AOQ54IZZ6J
NUCLEOSIDE_SUBSTITUTION	[1_2]	SITE_SPECIFIC	2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE	9Q36I4D9VB
NUCLEOSIDE_SUBSTITUTION	[1_9] [1_15]	SITE_SPECIFIC	5-METHYLDEOXYCYTIDINE	B200GV71QM