U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 14:24:17 UTC 2023
Edited
by admin
on Sat Dec 16 14:24:17 UTC 2023
Nucleic Acid Type DNA
Nucleic Acid Subtype
Sequence Type COMPLETE
Record UNII
5EO3CIJ3H7
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TOMINERSEN SODIUM
Common Name English
TOMINERSEN SODIUM [JAN]
Common Name English
DNA, D((2'-O-(2-METHOXYETHYL))M5RC-SP-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-SP-T-SP-A-SP-A-SP-M5C-SP-A-SP-T-SP-T-SP-G-SP-A-SP-M5C-SP-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))M5
Systematic Name English
ISIS-443139
Code English
Code System Code Type Description
FDA UNII
5EO3CIJ3H7
Created by admin on Sat Dec 16 14:24:17 UTC 2023 , Edited by admin on Sat Dec 16 14:24:17 UTC 2023
PRIMARY
Sugar Site Range Site Count
Deoxyribose (DNA) 1_6-1_15 10 / 20
2'-O-Methoxyethyl ribose 1_1-1_5;1_16-1_20 10 / 20
Linkage Site Range Site Count
Sodium Phosporothioate 1_1;1_5-1_16;1_19 14 / 19
1_2-1_4;1_17-1_18 5 / 19
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOSIDE_SUBSTITUTION [1_1] [1_3] [1_17] [1_18] [1_20] SITE_SPECIFIC 2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE AOQ54IZZ6J
NUCLEOSIDE_SUBSTITUTION [1_2] SITE_SPECIFIC 2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE 9Q36I4D9VB
NUCLEOSIDE_SUBSTITUTION [1_9] [1_15] SITE_SPECIFIC 5-METHYLDEOXYCYTIDINE B200GV71QM