Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Mon Mar 31 23:19:52 GMT 2025
by
admin
on
Mon Mar 31 23:19:52 GMT 2025
|
| Protein Type | ENZYME |
| Protein Sub Type | CYTOCHROME P450 |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
5DD3C4WV38
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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Preferred Name | English | ||
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Common Name | English | ||
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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P15538
Created by
admin on Mon Mar 31 23:19:53 GMT 2025 , Edited by admin on Mon Mar 31 23:19:53 GMT 2025
|
PRIMARY | |||
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5DD3C4WV38
Created by
admin on Mon Mar 31 23:19:53 GMT 2025 , Edited by admin on Mon Mar 31 23:19:53 GMT 2025
|
PRIMARY | |||
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457063-33-1
Created by
admin on Mon Mar 31 23:19:53 GMT 2025 , Edited by admin on Mon Mar 31 23:19:53 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TISSUE EXPRESSION -> PARENT |
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SUBSTRATE -> METABOLIC ENZYME |
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INHIBITOR -> TARGET |
osilodrostat inhibited the activity of human CYP11B1 dose-dependently with IC50 values of 2.5 ± 0.1 nM (n = 4).
IC50
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RADIOLIGAND->TARGET |
No selectivity for CYP11B2 over CYP11B1.
IC50
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RADIOLIGAND->TARGET |
BINDING
IC50
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RADIOLIGAND->TARGET |
BINDING
IC50
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INHIBITOR -> TARGET |
BINDING
IC50
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INHIBITOR -> TARGET |
Inhibits cortisol synthesis.
BINDING
IC50
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RADIOLIGAND->OFF TARGET |
Selectivity for CYP11B2 over CYP11B1 was higher for CDP2230 than for MTO and IMTO.
IC50
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INHIBITOR->OFF-TARGET |
IC50
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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| Molecular Formula | CHEMICAL |
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