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Approval Year

Substance Class Protein
Created
by admin
on Sat Jun 26 16:42:28 UTC 2021
Edited
by admin
on Sat Jun 26 16:42:28 UTC 2021
Protein Type ENZYME
Protein Sub Type CYTOCHROME P450
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
5DD3C4WV38
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYTOCHROME P450 11B1
Common Name English
CYTOCHROME P 450 11B1
Common Name English
HUMAN STEROID 11-BETA-HYDROXYLASE
Common Name English
11-BETA-HYDROXYLASE
Common Name English
CYTOCHROME P450 11B1, MITOCHONDRIAL, HUMAN
Common Name English
CYP11B1
Common Name English
HUMAN CYTOCHROME P450 11B1
Common Name English
Code System Code Type Description
UNIPROT
P15538
Created by admin on Sat Jun 26 16:42:28 UTC 2021 , Edited by admin on Sat Jun 26 16:42:28 UTC 2021
PRIMARY
FDA UNII
5DD3C4WV38
Created by admin on Sat Jun 26 16:42:28 UTC 2021 , Edited by admin on Sat Jun 26 16:42:28 UTC 2021
PRIMARY
CAS
457063-33-1
Created by admin on Sat Jun 26 16:42:28 UTC 2021 , Edited by admin on Sat Jun 26 16:42:28 UTC 2021
PRIMARY
Related Record Type Details
TISSUE EXPRESSION -> PARENT
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> TARGET
osilodrostat inhibited the activity of human CYP11B1 dose-dependently with IC50 values of 2.5 ± 0.1 nM (n = 4).
IC50
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL