BENZYLPIPERAZINE DIHYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H16N2.2ClH
Molecular Weight	249.18
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of BENZYLPIPERAZINE DIHYDROCHLORIDE

Structure Search

SMILES

Cl.Cl.C(N1CCNCC1)C2=CC=CC=C2

InChI

InChIKey=BBUJLUKPBBBXMU-UHFFFAOYSA-N

InChI=1S/C11H16N2.2ClH/c1-2-4-11(5-3-1)10-13-8-6-12-7-9-13;;/h1-5,12H,6-10H2;2*1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C11H16N2
Molecular Weight	176.2581
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine transporter 180 Target ID: CHEMBL238 Sources: https://doi.org/10.1080/03036758.2011.557036	Blocker 537
Serotonin 1 (5-HT1) receptor 9 Target ID: CHEMBL2095159 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2448760	Agonist 2678
Adrenergic receptor alpha-2 113 Target ID: CHEMBL2095158 Sources: Chan Wai Yeap, Chan Kee Bian, Ahmad Fahmi, Ahmad Fahmi Lim Abdullah, A Review on Benzylpiperazine and Trifluoromethylphenypiperazine: Origins, Effects, Prevalence and Legal Status. retrieved from: https://www.researchgate.net/publication/266484660_A_Review_on_Benzylpiperazine_and_Trifluoromethylphenypiperazine_Origins_Effects_Prevalence_and_Legal_Status	Antagonist 2778

PubMed

Title	Date	PubMed
Acute psychosis following ingestion of 'Rapture'.	2004 Dec	15715818
Multicomponent screening for drugs of abuse: direct analysis of urine by LC-MS-MS.	2004 Feb	14749556
Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.	2005 Dec 15	16257398
Researching the toxicity of party pills.	2005 Dec-2006 Jan	16529277
Simultaneous separation of different types of amphetamine and piperazine designer drugs by capillary electrophoresis with a chiral selector.	2005 Mar	15813543
Rewarding properties of 1-benzylpiperazine, a new drug of abuse, in rats.	2006 Apr	16623856
Treatment of adolescent rats with 1-benzylpiperazine: a preliminary study of subsequent behavioral effects.	2006 Jul-Aug	16828257
Seizures in a night club.	2007 Jul 21	17658391
MDMA-like behavioral effects of N-substituted piperazines in the mouse.	2007 Nov	17651790
Patterns of benzylpiperazine/trifluoromethylphenylpiperazine party pill use and adverse effects in a population sample in New Zealand.	2008 Nov	19378447
Selective suppression of cocaine- versus food-maintained responding by monoamine releasers in rhesus monkeys: benzylpiperazine, (+)phenmetrazine, and 4-benzylpiperidine.	2009 Apr	19151247
Pharmacokinetics of 'party pill' drug N-benzylpiperazine (BZP) in healthy human participants.	2009 Apr 15	19261399
Party pills and drug-drug interactions.	2009 Apr 24	19448787
Synthesis, optimization and structure-activity relationships of 3,5-disubstituted isoxazolines as new anti-tuberculosis agents.	2009 Feb	18524421
Metabolic interactions with piperazine-based 'party pill' drugs.	2009 Jul	19589229
1-benzylpiperazine (BZP) abuse amongst attendees of the Drug Treatment Centre Board.	2009 Jun	19722361
Differences in harm from legal BZP/TFMPP party pills between North Island and South Island users in New Zealand: a case of effective industry self-regulation?	2010 Jan	19359158
Purchasing 'legal highs' on the Internet--is there consistency in what you get?	2010 Jul	20413562
New benzofuran derivatives as an antioxidant agent.	2010 Mar	20838529
Multiorgan failure from 1-benzylpiperazine ingestion--legal high or lethal high?	2010 Mar	20184432
Hydride transfer reactions via ion-neutral complex: fragmentation of protonated N-benzylpiperidines and protonated N-benzylpiperazines in mass spectrometry.	2010 May	20301171
Detection of 1-benzylpiperazine, 1-(3-trifluoromethylphenyl)-piperazine, and 1-(3-chlorophenyl)-piperazine in 3,4-methylenedioxymethamphetamine-positive urine samples.	2010 Oct	21819791
A hybrid liquid chromatography-mass spectrometry strategy in a forensic laboratory for opioid, cocaine and amphetamine classes in human urine using a hybrid linear ion trap-triple quadrupole mass spectrometer.	2010 Oct 29	20855077
Randomised double-blind, placebo-controlled trial of the effects of the 'party pills' BZP/TFMPP alone and in combination with alcohol.	2010 Sep	19329546
Estrogenic effects and their action mechanism of the major active components of party pill drugs.	2012 Nov 15	23026265
Structure-dependent inhibition of the human α1β2γ2 GABAA receptor by piperazine derivatives: A novel mode of action.	2015 Dec	26344803

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 12:18:18 GMT 2023` Edited by `admin` on `Sat Dec 16 12:18:18 GMT 2023`
Record UNII	5CFGYMNN06
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BENZYLPIPERAZINE DIHYDROCHLORIDE

Common Name

English

N-BENZYLPIPERAZINE DIHYDROCHLORIDE

Systematic Name

English

1-BENZYLPIPERAZINE DIHYDROCHLORIDE

Systematic Name

English

PIPERAZINE, 1-(PHENYLMETHYL)-, DIHYDROCHLORIDE

Systematic Name

English

NSC-163993

Code

English

PIPERAZINE, 1-(PHENYLMETHYL)-, HYDROCHLORIDE (1:2)

Systematic Name

English

PIPERAZINE, 1-BENZYL-, DIHYDROCHLORIDE

Systematic Name

English

Code System Code Type Description

NSC

163993