BENZYLPIPERAZINE DIHYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H16N2.2ClH
Molecular Weight	249.18
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of BENZYLPIPERAZINE DIHYDROCHLORIDE

Structure Search

SMILES

Cl.Cl.C(N1CCNCC1)C2=CC=CC=C2

InChI

InChIKey=BBUJLUKPBBBXMU-UHFFFAOYSA-N

InChI=1S/C11H16N2.2ClH/c1-2-4-11(5-3-1)10-13-8-6-12-7-9-13;;/h1-5,12H,6-10H2;2*1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C11H16N2
Molecular Weight	176.2581
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine transporter 180 Target ID: CHEMBL238 Sources: https://doi.org/10.1080/03036758.2011.557036	Blocker 537
Serotonin 1 (5-HT1) receptor 9 Target ID: CHEMBL2095159 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2448760	Agonist 2678
Adrenergic receptor alpha-2 113 Target ID: CHEMBL2095158 Sources: Chan Wai Yeap, Chan Kee Bian, Ahmad Fahmi, Ahmad Fahmi Lim Abdullah, A Review on Benzylpiperazine and Trifluoromethylphenypiperazine: Origins, Effects, Prevalence and Legal Status. retrieved from: https://www.researchgate.net/publication/266484660_A_Review_on_Benzylpiperazine_and_Trifluoromethylphenypiperazine_Origins_Effects_Prevalence_and_Legal_Status	Antagonist 2778

PubMed

Title	Date	PubMed
Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.	2005 Dec 15	16257398
Toxic effects of BZP-based herbal party pills in humans: a prospective study in Christchurch, New Zealand.	2005 Dec 16	16372033
Researching the toxicity of party pills.	2005 Dec-2006 Jan	16529277
Simultaneous separation of different types of amphetamine and piperazine designer drugs by capillary electrophoresis with a chiral selector.	2005 Mar	15813543
Application of direct urine LC-MS-MS analysis for screening of novel substances in drug abusers.	2005 May-Jun	15975252
Metabolism and the urinary excretion profile of the recently scheduled designer drug N-Benzylpiperazine (BZP) in the rat.	2006 Jan-Feb	16620530
Copper(I) cyanide networks: synthesis, structure, and luminescence behavior. Part 2. Piperazine ligands and hexamethylenetetramine.	2008 Aug 4	18597424
Detection of 1-benzylpiperazine and 1-(3-trifluoromethylphenyl)-piperazine in urine analysis specimens using GC-MS and LC-ESI-MS.	2008 Jul-Aug	18652752
Selective suppression of cocaine- versus food-maintained responding by monoamine releasers in rhesus monkeys: benzylpiperazine, (+)phenmetrazine, and 4-benzylpiperidine.	2009 Apr	19151247
Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors.	2010 Dec	20926161
Purchasing 'legal highs' on the Internet--is there consistency in what you get?	2010 Jul	20413562
Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.	2010 Jul 22	20565112
Multiorgan failure from 1-benzylpiperazine ingestion--legal high or lethal high?	2010 Mar	20184432
Detection of 1-benzylpiperazine, 1-(3-trifluoromethylphenyl)-piperazine, and 1-(3-chlorophenyl)-piperazine in 3,4-methylenedioxymethamphetamine-positive urine samples.	2010 Oct	21819791
A hybrid liquid chromatography-mass spectrometry strategy in a forensic laboratory for opioid, cocaine and amphetamine classes in human urine using a hybrid linear ion trap-triple quadrupole mass spectrometer.	2010 Oct 29	20855077
Validation of an LC-MS method for the detection and quantification of BZP and TFMPP and their hydroxylated metabolites in human plasma and its application to the pharmacokinetic study of TFMPP in humans.	2010 Sep	20533987
Estrogenic effects and their action mechanism of the major active components of party pill drugs.	2012 Nov 15	23026265
Structure-dependent inhibition of the human α1β2γ2 GABAA receptor by piperazine derivatives: A novel mode of action.	2015 Dec	26344803

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 12:18:18 UTC 2023` Edited by `admin` on `Sat Dec 16 12:18:18 UTC 2023`
Record UNII	5CFGYMNN06
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BENZYLPIPERAZINE DIHYDROCHLORIDE

Common Name

English

N-BENZYLPIPERAZINE DIHYDROCHLORIDE

Systematic Name

English

1-BENZYLPIPERAZINE DIHYDROCHLORIDE

Systematic Name

English

PIPERAZINE, 1-(PHENYLMETHYL)-, DIHYDROCHLORIDE

Systematic Name

English

NSC-163993

Code

English

PIPERAZINE, 1-(PHENYLMETHYL)-, HYDROCHLORIDE (1:2)

Systematic Name

English

PIPERAZINE, 1-BENZYL-, DIHYDROCHLORIDE

Systematic Name

English

Code System Code Type Description

NSC

163993