Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H16ClNO3.ClH |
Molecular Weight | 294.174 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN(C)CCOC(=O)COC1=CC=C(Cl)C=C1
InChI
InChIKey=FIVHOHCAXWQPGC-UHFFFAOYSA-N
InChI=1S/C12H16ClNO3.ClH/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11;/h3-6H,7-9H2,1-2H3;1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C12H16ClNO3 |
Molecular Weight | 257.713 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://smart-drugs.net/article-lucidril.htmCurator's Comment: description was created based on several sources, including
http://toppharma.co.uk/top-pharma-product/powder-for-injection/meclofenoxate/
Sources: http://smart-drugs.net/article-lucidril.htm
Curator's Comment: description was created based on several sources, including
http://toppharma.co.uk/top-pharma-product/powder-for-injection/meclofenoxate/
Meclofenoxate (INN, BAN) (brand name Lucidril), also known as centrophenoxine, is a cholinergic nootropic used as a dietary supplement and drug in the treatment of symptoms of senile dementia and Alzheimer's disease. Meclofenoxate has been shown in studies to be effective in enhancing the memory and in improving the cognitive functions of the elderly. Some studies even suggest that Meclofenoxate has the ability to reverse the signs of brain aging. While claims about its ability as a nootropic agent have not been fully established in clinical trials, some studies do strongly suggest that it is indeed very effective in improving memory retention and recall. Meclofenoxate HCL Powder for Injection is also indicated for the following conditions: comma; skull and brain trauma; following a stroke; encephalopathy; mental disorders (in combination with psychotropic agents); mental and psychomotor retardation in children; brain intoxication; alcohol psychoses; neuritis and polyneuritis. The main mechanism of action of Meclofenoxate is generally believed to be cholinergic in nature. As an efficient transporter of DMAE, Meclofenoxate encourages the production of choline in the brain, which is then synthesized into acetylcholine. The more acetylcholine neurotransmitters in the brain, the better and more efficient the cognitive functions will be. Meclofenoxate also increases cellular membrane phospholipids
CNS Activity
Sources: http://nootropicsupplementreview.com/meclofenoxate/
Curator's Comment: Meclofenoxate increases the dimethylethanolamine or DMAE levels in the brain. DMAE is a precursor of acetylcholine, an important neurotransmitter in the brain believed to be responsible for most of the cognitive processes within it.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Can nootropic drugs be effective against the impact of ethanol teratogenicity on cognitive performance? | 2001 Feb |
|
Effect of centrophenoxine on water-immersion restraint stress- and chemically-induced gastric ulcers in rats. | 2003 |
|
Therapy of hearing disorders - conservative procedures. | 2005 |
|
Evidence for centrophenoxine as a protective drug in aluminium induced behavioral and biochemical alteration in rat brain. | 2006 Oct |
|
Stability-indicating electrochemical methods for the determination of meclophenoxate hydrochloride and pyritinol dihydrochloride using ion-selective membrane electrodes. | 2007 Jan |
|
A simple and sensitive HPLC method for quantification of the metabolin of meclofenoxate in human plasma. | 2010 May-Jun |
Patents
Sample Use Guides
Elderly people with significant intellectual decline may chose 3 to 6 Centrophenoxine tablets (250 mg) per day taken preferably with breakfast and lunch, in order to avoid insomnia.
For the non-elderly wishing to utilize the brain boosting benefits of Centrophenoxine, perhaps only 1 or 2 Centrophenoxine tablets (250 mg each) daily with breakfast or lunch.
Route of Administration:
Oral
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/3018064
The superoxide radical scavenging ability of centrophenoxine (CPH/MECLOFENOXATE) was studied in vitro using the method of pyrogallol autoxidation, cytochrome c reduction and photoxidation of o-dianisidine in salt-free assay media and in the presence of increasing NaCl or KCl concentrations. The CPH proved to be a superoxide radical scavenger in all three systems used, however, the rate constant for this reaction was rather low (1.7 X 10(2) M-1 s-1).
Substance Class |
Chemical
Created
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on
Edited
Thu Jul 06 02:03:26 UTC 2023
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Record UNII |
5BK3070BDY
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ACTIVE MOIETY |