CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE B

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 01:21:09 GMT 2025` Edited by `admin` on `Wed Apr 02 01:21:09 GMT 2025`
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	5AYQ2F6KU4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE B

Common Name

English

CGIPDE1

Preferred Name

English

CYCLIC GMP-INHIBITED PHOSPHODIESTERASE B

Common Name

English

PDE3B

Common Name

English

Code System Code Type Description

UNIPROT

Q13370

Created by admin on Wed Apr 02 01:21:09 GMT 2025 , Edited by admin on Wed Apr 02 01:21:09 GMT 2025

PRIMARY

FDA UNII

5AYQ2F6KU4

Created by admin on Wed Apr 02 01:21:09 GMT 2025 , Edited by admin on Wed Apr 02 01:21:09 GMT 2025

PRIMARY

Related Record Type Details


					V8Q1Z0GK92

RAFIGRELIDE

INHIBITOR->OFF-TARGET

Comments:

.


					2PCP9N33NH

PAROGRELIL

INHIBITOR -> TARGET

Amount:


					CYJ9ATV1IJ

PF-04217903

WEAK INHIBITOR->OFF TARGET

Comments:

No cardiac toxicity seen in clinical trials

Qualification:

IC50

Amount:


					UN4C7N5KVB

PF-04254644

INHIBITOR->OFF-TARGET

Comments:

May be responsible for myocarditis and cardiac toxicity

Qualification:

IC50

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_13] [1_296] [1_442]				DEXFOSFOSERINE	VI4F0K069V
AMINO ACID SUBSTITUTION	[1_295]				DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL