BIA-10-2474

CN(C1CCCCC1)C(=O)N2C=NC(=C2)C3=C[N+]([O-])=CC=C3

InChIKey=DOWVMJFBDGWVML-UHFFFAOYSA-N

InChI=1S/C16H20N4O2/c1-18(14-7-3-2-4-8-14)16(21)19-11-15(17-12-19)13-6-5-9-20(22)10-13/h5-6,9-12,14H,2-4,7-8H2,1H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Anandamide amidohydrolase 26 Target ID: CHEMBL2243 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28596366 \| https://www.ncbi.nlm.nih.gov/pubmed/27650910	Inhibitor 8297		4.9 nM [IC50]

PubMed

Title	Date	PubMed
Lessons from the fatal French study BIA-10-2474.	2016 May 18	27193592
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.	2017 Jun 9	28596366
Inhibition of fatty acid amide hydrolase by BIA 10-2474 in rat brain.	2017 Nov	27650910

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:14:52 UTC 2023` Edited by `admin` on `Sat Dec 16 10:14:52 UTC 2023`
Record UNII	5AP1ZW859M
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

BIA-10-2474

Common Name

English

BIA-102474-101

Code

English

BIA 10-2474

Code

English

1H-IMIDAZOLE-1-CARBOXAMIDE, N-CYCLOHEXYL-N-METHYL-4-(1-OXIDO-3-PYRIDINYL)-

Systematic Name

English

Code System Code Type Description

SMS_ID

300000041440