LEMINOPRAZOLE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H23N3OS
Molecular Weight	341.47
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)CN(C)C1=C(C[S+]([O-])C2=NC3=C(N2)C=CC=C3)C=CC=C1

InChI

InChIKey=PSIREIZGKQBEEO-UHFFFAOYSA-N

InChI=1S/C19H23N3OS/c1-14(2)12-22(3)18-11-7-4-8-15(18)13-24(23)19-20-16-9-5-6-10-17(16)21-19/h4-11,14H,12-13H2,1-3H3,(H,20,21)

HIDE SMILES / InChI

Molecular Formula	C19H23N3OS
Molecular Weight	341.47
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8569059 | https://adisinsight.springer.com/drugs/800000604

LEMINOPRAZOLE is an inhibitor of the gastric mucosal proton pump. Its development for the treatment of peptic ulcer was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Validity of kissing gastric ulcers induced in rats for screening of antiulcer drugs.	1994	7881021
Effects of NC-1300-O-3 on gastric mucus secretion and prostaglandin release in rats.	1994 Aug	7990269
Effect on gastric mucus of the proton pump inhibitor leminoprazole and its cytoprotective action against ethanol-induced gastric injury in rats.	1994 Jul	7945516
Antisecretory effect of leminoprazole on histamine-stimulated gastric acid secretion in dogs: potent local effect.	1995 Oct	8569059

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:31:44 UTC 2023` Edited by `admin` on `Sat Dec 16 16:31:44 UTC 2023`
Record UNII	59H7G93Y1T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LEMINOPRAZOLE

Official Name

English

LEMINOPRAZOLE [JAN]

Common Name

English

NC1300O3

Code

English

NC-1300O3

Code

English

2-(2-(N-ISOBUTYL-N-METHYLAMINO)BENZYLSULFINYL)BENZIMIDAZOLE

Systematic Name

English

BENZENAMINE, 2-((1H-BENZIMIDAZOL-2-YLSULFINYL)METHYL)-N-METHYL-N-(2-METHYLPROPYL)-

Systematic Name

English

(±)-2-((O-(ISOBUTYLMETHYLAMINO)BENZYL)SULFINYL)BENZIMIDAZOLE

Common Name

English

leminoprazole [INN]

Common Name

English

Code System Code Type Description

INN

7002