Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C6H14N2O3.2BrH |
| Molecular Weight | 324.011 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Br.Br.N[C@H]1C[C@@H](N)[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChIKey=FQPOWLZRZNUTOR-SKIYRPIFSA-N
InChI=1S/C6H14N2O3.2BrH/c7-2-1-3(8)5(10)6(11)4(2)9;;/h2-6,9-11H,1,7-8H2;2*1H/t2-,3+,4+,5-,6-;;
| Molecular Formula | BrH |
| Molecular Weight | 80.912 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C6H14N2O3 |
| Molecular Weight | 162.187 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| An efficient synthesis of mimetics of neamine for RNA recognition. | 2001 May 31 |
|
| Identification of L-glutamine: 2-deoxy-scyllo-inosose aminotransferase required for the biosynthesis of butirosin in Bacillus circulans. | 2002 Aug |
|
| Significance of the 20-kDa subunit of heterodimeric 2-deoxy-scyllo-inosose synthase for the biosynthesis of butirosin antibiotics in Bacillus circulans. | 2002 Jul |
|
| Importance of specific hydrogen-bond donor-acceptor interactions for the key carbocycle-forming reaction catalyzed by 2-deoxy-scyllo-inosose synthase in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics. | 2002 Jun 14 |
|
| Sequence-specific recognition of the major groove of RNA by deoxystreptamine. | 2002 May 21 |
|
| Molecular cloning and characterization of a 2-deoxystreptamine biosynthetic gene cluster in gentamicin-producing Micromonospora echinospora ATCC15835. | 2004 Aug 31 |
|
| Active site mapping of 2-deoxy-scyllo-inosose synthase, the key starter enzyme for the biosynthesis of 2-deoxystreptamine. Mechanism-based inhibition and identification of lysine-141 as the entrapped nucleophile. | 2004 Feb 6 |
|
| Rational design of azepane-glycoside antibiotics targeting the bacterial ribosome. | 2004 Feb 9 |
|
| Efficient preparation of a 1,3-diazidocyclitol as a versatile 2-deoxystreptamine precursor. | 2004 Jun 25 |
|
| Thermodynamics of aminoglycoside binding to aminoglycoside-3'-phosphotransferase IIIa studied by isothermal titration calorimetry. | 2004 Nov 23 |
|
| Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes. | 2005 Nov 15 |
|
| Biochemical and thermodynamic characterization of compounds that bind to RNA hairpin loops: toward an understanding of selectivity. | 2006 Sep 12 |
|
| A convenient synthesis of orthogonally protected 2-deoxystreptamine (2-DOS) as an aminocyclitol scaffold for the development of novel aminoglycoside antibiotic derivatives against bacterial resistance. | 2008 Aug 21 |
|
| Medium- and short-chain dehydrogenase/reductase gene and protein families : the MDR superfamily. | 2008 Dec |
|
| Heterologous production and detection of recombinant directing 2-deoxystreptamine (DOS) in the non-aminoglycoside-producing host Streptomyces venezuelae YJ003. | 2008 May |
|
| The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase. | 2008 Sep 21 |
|
| Aminoglycosides: molecular insights on the recognition of RNA and aminoglycoside mimics. | 2009 Apr 28 |
|
| Asymmetric desymmetrization of 4,5-epoxycyclohex-1-ene by enantioselective allylic oxidation. | 2009 Aug 6 |
|
| Revisiting plus-strand DNA synthesis in retroviruses and long terminal repeat retrotransposons: dynamics of enzyme: substrate interactions. | 2009 Dec |
|
| Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853. | 2009 May 31 |
|
| Synthesis of neamine-derived pseudodisaccharides by stereo- and regio-selective functional group transformations. | 2009 Oct 21 |
|
| Development of a multicommutated flow system with chemiluminometric detection for quantification of gentamicin in pharmaceuticals. | 2010 |
|
| Mutation K42R in ribosomal protein S12 does not affect susceptibility of Mycobacterium smegmatis 16S rRNA A-site mutants to 2-deoxystreptamines. | 2010 Aug 5 |
|
| Biosynthesis of paromamine derivatives in engineered Escherichia coli by heterologous expression. | 2010 May |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 19:57:31 GMT 2023
by
admin
on
Sat Dec 16 19:57:31 GMT 2023
|
| Record UNII |
58G24HT23E
|
| Record Status |
Validated (UNII)
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| Record Version |
|
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| Name | Type | Language | ||
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Systematic Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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84107-26-6
Created by
admin on Sat Dec 16 19:57:31 GMT 2023 , Edited by admin on Sat Dec 16 19:57:31 GMT 2023
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PRIMARY | |||
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58G24HT23E
Created by
admin on Sat Dec 16 19:57:31 GMT 2023 , Edited by admin on Sat Dec 16 19:57:31 GMT 2023
|
PRIMARY |
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PARENT -> SALT/SOLVATE |
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