ATOMOXETINE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H21NO.ClH
Molecular Weight	291.816
Optical Activity	( - )
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CNCC[C@@H](OC1=C(C)C=CC=C1)C2=CC=CC=C2

InChI

InChIKey=LUCXVPAZUDVVBT-UNTBIKODSA-N

InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C17H21NO
Molecular Weight	255.3547
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21411_strattera_lbl.pdf
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/pro/atomoxetine.html

Atomoxetine is indicated for the treatment of Attention-Deficit/Hyperactivity Disorder. The precise mechanism by which atomoxetine produces its therapeutic effects in Attention-Deficit/Hyperactivity Disorder (ADHD) is unknown, but is thought to be related to selective inhibition of the pre-synaptic norepinephrine transporter. Most common adverse reactions are: nausea, vomiting, fatigue, decreased appetite, abdominal pain, and somnolence, constipation, dry mouth, dizziness, erectile dysfunction, and urinary hesitation. Atomoxetine is a substrate for CYP2D6 and hence concurrent treatment with CYP2D6 inhibitors such as bupropion (Wellbutrin) or fluoxetine (Prozac) is not recommended, as this can lead to significant elevations of plasma atomoxetine levels.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Norepinephrine transporter 183 Target ID: CHEMBL222 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21411_strattera_lbl.pdf \| https://www.ncbi.nlm.nih.gov/pubmed/12431845 \| https://www.ncbi.nlm.nih.gov/pubmed/23933039	Inhibitor 8146	5.0 nM [Ki]
Serotonin transporter 172 Target ID: CHEMBL228 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12431845 \| https://www.ncbi.nlm.nih.gov/pubmed/23933039	Inhibitor 8146	77.0 nM [Ki]
Dopamine transporter 172 Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12431845	Inhibitor 8146	1451.0 nM [Ki]
Glutamate receptor ionotropic, NMDA 2A 2 Target ID: Q00959 Gene ID: 24409.0 Gene Symbol: Grin2a Target Organism: Rattus norvegicus (Rat) Sources: https://www.ncbi.nlm.nih.gov/pubmed/20423340	Antagonist 2737	1.58 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Attention deficit hyperactivity disorder 66 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21411_strattera_lbl.pdf	Primary		Approved 8307	STRATTERA Approved Use Attention-Deficit/Hyperactivity Disorder (ADHD) STRATTERA is indicated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD). The efficacy of STRATTERA Capsules was established in seven clinical trials in outpatients with ADHD: four 6 to 9-week trials in pediatric patients (ages 6 to 18), two 10-week trial in adults, and one maintenance trial in pediatrics (ages 6 to 15) [see Clinical Studies (14) Launch Date 1.03826883E12

C_max

Value	Dose	Co-administered	Analyte	Population
414.82 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23812961	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:		ATOMOXETINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
2693.29 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23812961	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:		ATOMOXETINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
3.64 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23812961	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:		ATOMOXETINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
2% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021411s035lbl.pdf			ATOMOXETINE plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
180 mg single, oral Overdose Dose: 180 mg Route: oral Route: single Dose: 180 mg Sources: https://pubmed.ncbi.nlm.nih.gov/15732449/	unhealthy, 12 years n = 1 Health Status: unhealthy Condition: mistakenly instead of dextroampheta Age Group: 12 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/15732449/	Disc. AE: Tachycardia... AEs leading to discontinuation/dose reduction: Tachycardia (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/15732449/
480 mg 1 times / day steady, oral Highest studied dose Dose: 480 mg, 1 times / day Route: oral Route: steady Dose: 480 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, 14 years n = 1 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: 14 years Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	Disc. AE: Hypertension... AEs leading to discontinuation/dose reduction: Hypertension (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
2840 mg single, oral Overdose Dose: 2840 mg Route: oral Route: single Dose: 2840 mg Sources: https://pubmed.ncbi.nlm.nih.gov/17307628/	healthy, 17 years n = 1 Health Status: healthy Condition: attempted suicide Age Group: 17 years Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/17307628/	Disc. AE: Sinus tachycardia... AEs leading to discontinuation/dose reduction: Sinus tachycardia (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/17307628/
1.2 g single, oral Overdose Dose: 1.2 g Route: oral Route: single Dose: 1.2 g Co-administed with:: oxcarbazepine(36 g) Quetiapine(9 mg) Sources: https://pubmed.ncbi.nlm.nih.gov/15171487/	unknown, 19 years n = 1 Health Status: unknown Age Group: 19 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/15171487/	Disc. AE: Depression central nervous system... AEs leading to discontinuation/dose reduction: Depression central nervous system (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/15171487/
40 mg 2 times / day steady, oral Recommended Dose: 40 mg, 2 times / day Route: oral Route: steady Dose: 40 mg, 2 times / day Co-administed with:: fluoxetine Sources: https://pubmed.ncbi.nlm.nih.gov/27123802/	unhealthy, 26 years n = 1 Health Status: unhealthy Condition: temper outbursts, impulsivity, difficulty paying attention, marital discord Age Group: 26 years Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/27123802/	Disc. AE: ST segment elevation myocardial infarction... AEs leading to discontinuation/dose reduction: ST segment elevation myocardial infarction (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/27123802/
1.8 mg/kg 1 times / day steady, oral Highest studied dose Dose: 1.8 mg/kg, 1 times / day Route: oral Route: steady Dose: 1.8 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21422081/	unhealthy, 5 - 6 years n = 44 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: 5 - 6 years Sex: M+F Population Size: 44 Sources: https://pubmed.ncbi.nlm.nih.gov/21422081/	Sources: https://pubmed.ncbi.nlm.nih.gov/21422081/
120 mg 1 times / day steady, oral (max) Studied dose Dose: 120 mg, 1 times / day Route: oral Route: steady Dose: 120 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/	unhealthy, adult n = 45 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: adult Sex: unknown Population Size: 45 Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/	Disc. AE: Nausea, Malaise... AEs leading to discontinuation/dose reduction: Nausea (1 patient) Malaise (1 patient) Anorexia (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/
249 mg 1 times / day steady, oral (mean) Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children n = 40 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: children Sex: M+F Population Size: 40 Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	Other AEs: Drowsiness, Tachycardia... Other AEs: Drowsiness (10 patients) Tachycardia (6 patients) Nausea (3 patients) Hypertension (2 patients) Vomiting (2 patients) Seizure (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/

AEs

AE	Significance	Dose	Population
Tachycardia	1 patient Disc. AE	180 mg single, oral Overdose Dose: 180 mg Route: oral Route: single Dose: 180 mg Sources: https://pubmed.ncbi.nlm.nih.gov/15732449/	unhealthy, 12 years n = 1 Health Status: unhealthy Condition: mistakenly instead of dextroampheta Age Group: 12 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/15732449/
Hypertension	1 patient Disc. AE	480 mg 1 times / day steady, oral Highest studied dose Dose: 480 mg, 1 times / day Route: oral Route: steady Dose: 480 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, 14 years n = 1 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: 14 years Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
Sinus tachycardia	1 patient Disc. AE	2840 mg single, oral Overdose Dose: 2840 mg Route: oral Route: single Dose: 2840 mg Sources: https://pubmed.ncbi.nlm.nih.gov/17307628/	healthy, 17 years n = 1 Health Status: healthy Condition: attempted suicide Age Group: 17 years Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/17307628/
Depression central nervous system	1 patient Disc. AE	1.2 g single, oral Overdose Dose: 1.2 g Route: oral Route: single Dose: 1.2 g Co-administed with:: oxcarbazepine(36 g) Quetiapine(9 mg) Sources: https://pubmed.ncbi.nlm.nih.gov/15171487/	unknown, 19 years n = 1 Health Status: unknown Age Group: 19 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/15171487/
ST segment elevation myocardial infarction	1 patient Disc. AE	40 mg 2 times / day steady, oral Recommended Dose: 40 mg, 2 times / day Route: oral Route: steady Dose: 40 mg, 2 times / day Co-administed with:: fluoxetine Sources: https://pubmed.ncbi.nlm.nih.gov/27123802/	unhealthy, 26 years n = 1 Health Status: unhealthy Condition: temper outbursts, impulsivity, difficulty paying attention, marital discord Age Group: 26 years Sex: F Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/27123802/
Anorexia	1 patient Disc. AE	120 mg 1 times / day steady, oral (max) Studied dose Dose: 120 mg, 1 times / day Route: oral Route: steady Dose: 120 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/	unhealthy, adult n = 45 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: adult Sex: unknown Population Size: 45 Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/
Malaise	1 patient Disc. AE	120 mg 1 times / day steady, oral (max) Studied dose Dose: 120 mg, 1 times / day Route: oral Route: steady Dose: 120 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/	unhealthy, adult n = 45 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: adult Sex: unknown Population Size: 45 Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/
Nausea	1 patient Disc. AE	120 mg 1 times / day steady, oral (max) Studied dose Dose: 120 mg, 1 times / day Route: oral Route: steady Dose: 120 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/	unhealthy, adult n = 45 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: adult Sex: unknown Population Size: 45 Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/
Seizure	1 patient	249 mg 1 times / day steady, oral (mean) Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children n = 40 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: children Sex: M+F Population Size: 40 Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
Drowsiness	10 patients	249 mg 1 times / day steady, oral (mean) Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children n = 40 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: children Sex: M+F Population Size: 40 Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
Hypertension	2 patients	249 mg 1 times / day steady, oral (mean) Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children n = 40 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: children Sex: M+F Population Size: 40 Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
Vomiting	2 patients	249 mg 1 times / day steady, oral (mean) Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children n = 40 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: children Sex: M+F Population Size: 40 Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
Nausea	3 patients	249 mg 1 times / day steady, oral (mean) Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children n = 40 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: children Sex: M+F Population Size: 40 Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
Tachycardia	6 patients	249 mg 1 times / day steady, oral (mean) Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children n = 40 Health Status: unhealthy Condition: attention deficit hyperactivity disorder Age Group: children Sex: M+F Population Size: 40 Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 1532 inducer 753 substrate 1670	inhibitor 1695 inducer 372 substrate 985	substrate 1168 inhibitor 1789 inducer 97	inhibitor 1570

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP1A2 1463	P-gp 1491 CYP2C19 955 CYP1A2 1013 CYP2A6 510 CYP2B6 648 CYP2E1 633	CYP1A2 671

Drug as perpetrator

Target	Modality	Activity	Clinical evidence
CYP1A2 1620	inducer 1515 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 30	no
CYP1A2 1620	inhibitor 3185 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 30	no
CYP2C9 1747	inducer 1515 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 30	no
CYP2C9 1747	inhibitor 3185 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 30	no
CYP2D6 1826	inducer 1515 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 30	no
CYP3A4 1857	inducer 1515 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 30	no
CYP2D6 1826	inhibitor 3185 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 28, 30	no	no (co-administration study) Comment: coadministration with desipramine did not alter the PK of desipramine Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 28, 30
CYP3A4 1857	inhibitor 3185 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 28, 30	no	no (co-administration study) Comment: coadministration with midazolam increased AUC by 15% Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 28, 30

Drug as victim

Target	Modality	Activity	Clinical evidence
CYP2D6 1168	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 8, 11, 22	major	yes (co-administration study) Comment: coadministration with paroxetine or fluoxetine increased atomoxetine steady-state plasma concentrations Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 8, 11, 22
P-gp 1491	substrate 3264 Sources: https://pubmed.ncbi.nlm.nih.gov/17963743/	unlikely
CYP1A2 1013	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22.0	weak
CYP2A6 510	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22.0	weak
CYP2B6 648	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22.0	weak
CYP2C9 985	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22.0	weak
CYP2E1 633	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22.0	weak
CYP3A4 1670	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22.0	weak
CYP2C19 955	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22.0	yes

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 1603	inhibitor 1584 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_pharmr_P1.pdf Page: 15.0

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:127342	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:127342
ChemicalBook	CB3378328	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB3378328
MolPort	MolPort-002-052-062	https://www.molport.com/shop/molecule-link/MolPort-002-052-062
ZINC	ZINC000001842633	http://zinc15.docking.org/substances/ZINC000001842633
eMolecules	1883572	https://www.emolecules.com/cgi-bin/more?vid=1883572

PubMed

Title	Date	PubMed
New treatments and approaches for attention deficit hyperactivity disorder.	2001 Apr	11276402
Safety profile of atomoxetine in the treatment of children and adolescents with ADHD.	2002	12562062
Drug development process for a product with a primary pediatric indication.	2002	12562061
Brain circuits determine destiny in depression: a novel approach to the psychopharmacology of wakefulness, fatigue, and executive dysfunction in major depressive disorder.	2003	14658930
Atomoxetine.	2003	12765489
Pharmacologic treatment approaches for children and adolescents with posttraumatic stress disorder.	2003 Apr	12725011
Atomoxetine (strattera) for ADHD.	2003 Feb 3	12571539
Disposition and metabolic fate of atomoxetine hydrochloride: the role of CYP2D6 in human disposition and metabolism.	2003 Jan	12485958
Atomoxetine: a selective noradrenaline reuptake inhibitor for the treatment of attention-deficit/hyperactivity disorder.	2003 Jul	12831341
Strattera approved to treat ADHD.	2003 Mar-Apr	12715751
Gateways to clinical trials.	2003 May	12808477
Atomoxetine for attention deficit/hyperactivity disorder.	2003 May	12751480
Atomoxetine for ADHD.	2003 Nov 1	14620603
The use of antidepressants to treat attention deficit hyperactivity disorder in adults.	2003 Sep	14513926
Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential.	2003 Sep	12768267
Atomoxetine pharmacokinetics in children and adolescents with attention deficit hyperactivity disorder.	2003 Spring	12804126
Non-stimulant medications in the treatment of ADHD.	2004	15322961
Spotlight on atomoxetine in adults with attention-deficit hyperactivity disorder.	2004	15089111
Impact of ADHD and its treatment on substance abuse in adults.	2004	15046534
ADHD treatment across the life cycle.	2004	15046532
A prospective, multicenter, open-label assessment of atomoxetine in non-North American children and adolescents with ADHD.	2004 Aug	15365896
Atomoxetine (Strattera) revisited.	2004 Aug 16	15314585
Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial kappa-opioid agonist effect.	2004 Aug 2	15225731
[Tourette syndrome: an analysis of its comorbidity and specific treatment].	2004 Feb	15011166
[New therapeutic options in the treatment of attention deficit/hyperactivity disorder].	2004 Feb	15011165
New drugs 04, part 1.	2004 Feb	14758333
Atomoxetine hydrochloride: clinical drug-drug interaction prediction and outcome.	2004 Feb	14610241
[Medical treatments of hyperactive child].	2004 Jan	14700769
Gateways to clinical trials.	2004 Jan-Feb	14988742
Once-daily atomoxetine treatment for children with attention-deficit/hyperactivity disorder, including an assessment of evening and morning behavior: a double-blind, placebo-controlled trial.	2004 Jul	15231966
Relapse prevention in pediatric patients with ADHD treated with atomoxetine: a randomized, double-blind, placebo-controlled study.	2004 Jul	15213591
The link between health-related quality of life and clinical symptoms among children with attention-deficit hyperactivity disorder.	2004 Jun	15194901
Acute oxcarbazepine and atomoxetine overdose with quetiapine.	2004 Jun	15171487
Pharmacological management of attention-deficit hyperactivity disorder.	2004 Jun	15163276
New drugs of 2003.	2004 Mar-Apr	15098851
Atomoxetine--treatment of attention deficit hyperactivity disorder: beyond stimulants.	2004 May	15319800
Atomoxetine hydrochloride.	2004 May	15152632
New drugs for the treatment of attention-deficit/hyperactivity disorder.	2004 Nov	15571486
Combining stimulants with monoamine oxidase inhibitors: a review of uses and one possible additional indication.	2004 Nov	15554766
Atomoxetine: the first nonstimulant for the management of attention-deficit/hyperactivity disorder.	2004 Nov 15	15581262
A lifetime of distractions. ADHD is no longer just a children's disease. Many adults are being diagnosed and treated for the condition.	2004 Oct	15496372
[Atomoxetine for the treatment of attention-deficit/hyperactivity disorder].	2004 Oct	15472782
Mania induction associated with atomoxetine.	2004 Oct	15349024
Management of hyperactivity and other acting-out problems in patients with autism spectrum disorder.	2004 Sep	15575418
Aggression, mania, and hypomania induction associated with atomoxetine.	2004 Sep	15342872
Atomoxetine and tics in ADHD.	2004 Sep	15322408
Atomoxetine and stimulants in combination for treatment of attention deficit hyperactivity disorder: four case reports.	2004 Spring	15142400

Patents

Sample Use Guides

In Vivo Use Guide

Atomoxetine should be initiated at a total daily dose of approximately 0.5 mg/kg and increased after a minimum of 3 days to a target total daily dose of approximately 1.2 mg/kg administered either as a single daily dose in the morning or as evenly divided doses in the morning and late afternoon/early evening. No additional benefit has been demonstrated for doses higher than 1.2 mg/kg/day.

Route of Administration: Oral

In Vitro Use Guide

Electrophysiological recordings was performed with the extracellular standard solution at different membrane potentials ranging from -80 mV to +40 mV while the concentration of the agonists (100 uM NMDA/10 uM glycine) and the antagonist (25 uM atomoxetine) were kept constant. The inhibitory effect was clearly voltage-dependent, so that the inhibition was attenuated by depolarization.

Substance Class	Chemical Created by `admin` on `Fri Dec 16 16:00:43 UTC 2022` Edited by `admin` on `Fri Dec 16 16:00:43 UTC 2022`
Record UNII	57WVB6I2W0
Record Status	`Validated (UNII)`
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Name

Type

Language

ATOMOXETINE HYDROCHLORIDE

Official Name

English

NSC-759104

Code

English

ATOMOXETINE HCL [VANDF]

Common Name

English

(-)-N-METHYL-3-PHENYL-3-(O-TOLYLOXY)PROPYLAMINE HYDROCHLORIDE

Systematic Name

English

ATOMOXETINE HYDROCHLORIDE [EP MONOGRAPH]

Common Name

English

ATOMOXETINE HCL

Common Name

English

ATOMOXETINE HYDROCHLORIDE [USP-RS]

Common Name

English

ATOMOXETINE HYDROCHLORIDE [JAN]

Common Name

English

LY-139603

Code

English

ATOMOXETINE HYDROCHLORIDE [USP MONOGRAPH]

Common Name

English

ATOMOXETINE (AS HYDROCHLORIDE)

Common Name

English

TOMOXETINE HYDROCHLORIDE

Common Name

English

Atomoxetine hydrochloride [WHO-DD]

Common Name

English

ATOMOXETINE HYDROCHLORIDE [MI]

Common Name

English

STRATTERA

Brand Name

English

ATOMOXETINE HYDROCHLORIDE [MART.]

Common Name

English

ATOMOXETINE HYDROCHLORIDE [ORANGE BOOK]

Common Name

English

BENZENEPROPANAMINE, N-METHYL-.GAMMA.-(2-METHYLPHENOXY)-, HYDROCHLORIDE, (-)

Common Name

English

ATOMOXETINE HYDROCHLORIDE [USAN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

173003