ATOMOXETINE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H21NO.ClH
Molecular Weight	291.8163
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cc1ccccc1O[C@]([H])(CCNC)c2ccccc2.Cl

InChI

InChIKey=LUCXVPAZUDVVBT-UNTBIKODSA-N

InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.4609
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C17H21NO
Molecular Weight	255.3554
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21411_strattera_lbl.pdf
Curator's Comment:: https://www.drugs.com/pro/atomoxetine.html

Atomoxetine is indicated for the treatment of Attention-Deficit/Hyperactivity Disorder. The precise mechanism by which atomoxetine produces its therapeutic effects in Attention-Deficit/Hyperactivity Disorder (ADHD) is unknown, but is thought to be related to selective inhibition of the pre-synaptic norepinephrine transporter. Most common adverse reactions are: nausea, vomiting, fatigue, decreased appetite, abdominal pain, and somnolence, constipation, dry mouth, dizziness, erectile dysfunction, and urinary hesitation. Atomoxetine is a substrate for CYP2D6 and hence concurrent treatment with CYP2D6 inhibitors such as bupropion (Wellbutrin) or fluoxetine (Prozac) is not recommended, as this can lead to significant elevations of plasma atomoxetine levels.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Norepinephrine transporter 183 Target ID: CHEMBL222 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21411_strattera_lbl.pdf \| https://www.ncbi.nlm.nih.gov/pubmed/12431845 \| https://www.ncbi.nlm.nih.gov/pubmed/23933039	Inhibitor 7687	Attention deficit hyperactivity disorder	5 nM [Ki]
Serotonin transporter 163 Target ID: CHEMBL228 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12431845 \| https://www.ncbi.nlm.nih.gov/pubmed/23933039	Inhibitor 7687	Attention deficit hyperactivity disorder	77 nM [Ki]
Dopamine transporter 173 Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12431845	Inhibitor 7687	Attention deficit hyperactivity disorder	1451 nM [Ki]
Glutamate receptor ionotropic, NMDA 2A 2 Target ID: Q00959 Gene ID: 24409 Gene Symbol: Grin2a Target Organism: Rattus norvegicus (Rat) Sources: https://www.ncbi.nlm.nih.gov/pubmed/20423340	Antagonist 2575	Attention deficit hyperactivity disorder	1.58000000000000007 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Attention deficit hyperactivity disorder 63 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21411_strattera_lbl.pdf	Primary	Norepinephrine transporter Serotonin transporter Dopamine transporter Glutamate receptor ionotropic, NMDA 2A	Approved 7968	STRATTERA Approved Use Attention-Deficit/Hyperactivity Disorder (ADHD) STRATTERA is indicated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD). The efficacy of STRATTERA Capsules was established in seven clinical trials in outpatients with ADHD: four 6 to 9-week trials in pediatric patients (ages 6 to 18), two 10-week trial in adults, and one maintenance trial in pediatrics (ages 6 to 15) [see Clinical Studies (14) Launch Date 1038268800000

C_max

Value	Dose	Co-administered	Analyte	Population
414.82 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23812961	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:		ATOMOXETINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
2693.29 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23812961	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:		ATOMOXETINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
3.64 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23812961	40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered:		ATOMOXETINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
2% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021411s035lbl.pdf			ATOMOXETINE plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
180 mg single, oral Overdose Dose: 180 mg Route: oral Route: single Dose: 180 mg Sources: https://pubmed.ncbi.nlm.nih.gov/15732449/	unhealthy, 12 years Health Status: unhealthy Age Group: 12 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/15732449/	Disc. AE: Tachycardia... AEs leading to discontinuation/dose reduction: Tachycardia (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/15732449/
480 mg 1 times / day steady, oral Highest studied dose Dose: 480 mg, 1 times / day Route: oral Route: steady Dose: 480 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, 14 years Health Status: unhealthy Age Group: 14 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	Disc. AE: Hypertension... AEs leading to discontinuation/dose reduction: Hypertension (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
2840 mg single, oral Overdose Dose: 2840 mg Route: oral Route: single Dose: 2840 mg Sources: https://pubmed.ncbi.nlm.nih.gov/17307628/	healthy, 17 years Health Status: healthy Age Group: 17 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/17307628/	Disc. AE: Sinus tachycardia... AEs leading to discontinuation/dose reduction: Sinus tachycardia (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/17307628/
1.2 g single, oral Overdose Dose: 1.2 g Route: oral Route: single Dose: 1.2 g Sources: https://pubmed.ncbi.nlm.nih.gov/15171487/	unknown, 19 years Health Status: unknown Age Group: 19 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/15171487/	Disc. AE: Depression central nervous system... AEs leading to discontinuation/dose reduction: Depression central nervous system (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/15171487/
40 mg 2 times / day steady, oral Recommended Dose: 40 mg, 2 times / day Route: oral Route: steady Dose: 40 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/27123802/	unhealthy, 26 years Health Status: unhealthy Age Group: 26 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/27123802/	Disc. AE: ST segment elevation myocardial infarction... AEs leading to discontinuation/dose reduction: ST segment elevation myocardial infarction (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/27123802/
1.8 mg/kg 1 times / day steady, oral Highest studied dose Dose: 1.8 mg/kg, 1 times / day Route: oral Route: steady Dose: 1.8 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21422081/	unhealthy, 5 - 6 years Health Status: unhealthy Age Group: 5 - 6 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/21422081/	Sources: https://pubmed.ncbi.nlm.nih.gov/21422081/
120 mg 1 times / day steady, oral Studied dose Dose: 120 mg, 1 times / day Route: oral Route: steady Dose: 120 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/	unhealthy, adult Health Status: unhealthy Age Group: adult Sex: unknown Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/	Disc. AE: Nausea, Malaise... AEs leading to discontinuation/dose reduction: Nausea (1 patient) Malaise (1 patient) Anorexia (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/
249 mg 1 times / day steady, oral Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children Health Status: unhealthy Age Group: children Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	Other AEs: Drowsiness, Tachycardia... Other AEs: Drowsiness (10 patients) Tachycardia (6 patients) Nausea (3 patients) Hypertension (2 patients) Vomiting (2 patients) Seizure (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/

AEs

AE	Significance	Dose	Population
Tachycardia	1 patient Disc. AE	180 mg single, oral Overdose Dose: 180 mg Route: oral Route: single Dose: 180 mg Sources: https://pubmed.ncbi.nlm.nih.gov/15732449/	unhealthy, 12 years Health Status: unhealthy Age Group: 12 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/15732449/
Hypertension	1 patient Disc. AE	480 mg 1 times / day steady, oral Highest studied dose Dose: 480 mg, 1 times / day Route: oral Route: steady Dose: 480 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, 14 years Health Status: unhealthy Age Group: 14 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
Sinus tachycardia	1 patient Disc. AE	2840 mg single, oral Overdose Dose: 2840 mg Route: oral Route: single Dose: 2840 mg Sources: https://pubmed.ncbi.nlm.nih.gov/17307628/	healthy, 17 years Health Status: healthy Age Group: 17 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/17307628/
Depression central nervous system	1 patient Disc. AE	1.2 g single, oral Overdose Dose: 1.2 g Route: oral Route: single Dose: 1.2 g Sources: https://pubmed.ncbi.nlm.nih.gov/15171487/	unknown, 19 years Health Status: unknown Age Group: 19 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/15171487/
ST segment elevation myocardial infarction	1 patient Disc. AE	40 mg 2 times / day steady, oral Recommended Dose: 40 mg, 2 times / day Route: oral Route: steady Dose: 40 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/27123802/	unhealthy, 26 years Health Status: unhealthy Age Group: 26 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/27123802/
Anorexia	1 patient Disc. AE	120 mg 1 times / day steady, oral Studied dose Dose: 120 mg, 1 times / day Route: oral Route: steady Dose: 120 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/	unhealthy, adult Health Status: unhealthy Age Group: adult Sex: unknown Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/
Malaise	1 patient Disc. AE	120 mg 1 times / day steady, oral Studied dose Dose: 120 mg, 1 times / day Route: oral Route: steady Dose: 120 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/	unhealthy, adult Health Status: unhealthy Age Group: adult Sex: unknown Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/
Nausea	1 patient Disc. AE	120 mg 1 times / day steady, oral Studied dose Dose: 120 mg, 1 times / day Route: oral Route: steady Dose: 120 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/	unhealthy, adult Health Status: unhealthy Age Group: adult Sex: unknown Sources: https://pubmed.ncbi.nlm.nih.gov/21265936/
Seizure	1 patient	249 mg 1 times / day steady, oral Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children Health Status: unhealthy Age Group: children Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
Drowsiness	10 patients	249 mg 1 times / day steady, oral Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children Health Status: unhealthy Age Group: children Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
Hypertension	2 patients	249 mg 1 times / day steady, oral Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children Health Status: unhealthy Age Group: children Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
Vomiting	2 patients	249 mg 1 times / day steady, oral Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children Health Status: unhealthy Age Group: children Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
Nausea	3 patients	249 mg 1 times / day steady, oral Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children Health Status: unhealthy Age Group: children Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/
Tachycardia	6 patients	249 mg 1 times / day steady, oral Highest studied dose Dose: 249 mg, 1 times / day Route: oral Route: steady Dose: 249 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/	unhealthy, children Health Status: unhealthy Age Group: children Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/15870137/

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 1171 inducer 657 substrate 1469	inhibitor 1318 inducer 343 substrate 865	substrate 1038 inhibitor 1421 inducer 93	inhibitor 1359

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP1A2 1268	P-gp 1222 CYP2C19 830 CYP1A2 892 CYP2A6 452 CYP2B6 575 CYP2E1 567	CYP1A2 618

Drug as perpetrator

Target	Modality	Activity	Clinical evidence
CYP1A2 1406	inducer 1333 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 30	no
CYP1A2 1406	inhibitor 2612 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 30	no
CYP2C9 1362	inducer 1333 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 30	no
CYP2C9 1362	inhibitor 2612 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 30	no
CYP2D6 1455	inducer 1333 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 30	no
CYP3A4 1461	inducer 1333 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 30	no
CYP2D6 1455	inhibitor 2612 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 28, 30	no	no (co-administration study) Comment: coadministration with desipramine did not alter the PK of desipramine Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 28, 30
CYP3A4 1461	inhibitor 2612 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 28, 30	no	no (co-administration study) Comment: coadministration with midazolam increased AUC by 15% Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 11, 28, 30

Drug as victim

Target	Modality	Activity	Clinical evidence
CYP2D6 1038	substrate 2751 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 8, 11, 22	major	yes (co-administration study) Comment: coadministration with paroxetine or fluoxetine increased atomoxetine steady-state plasma concentrations Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 8, 11, 22
P-gp 1222	substrate 2751 Sources: https://pubmed.ncbi.nlm.nih.gov/17963743/	unlikely
CYP1A2 892	substrate 2751 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22	weak
CYP2A6 452	substrate 2751 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22	weak
CYP2B6 575	substrate 2751 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22	weak
CYP2C9 865	substrate 2751 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22	weak
CYP2E1 567	substrate 2751 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22	weak
CYP3A4 1469	substrate 2751 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22	weak
CYP2C19 830	substrate 2751 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_biopharmr_P1.pdf Page: 22	yes

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 1391	inhibitor 1373 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-411_Strattera_pharmr_P1.pdf Page: 15

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:127342	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:127342
MolPort	MolPort-002-052-062	https://www.molport.com/shop/molecule-link/MolPort-002-052-062
ZINC	ZINC000001842633	http://zinc15.docking.org/substances/ZINC000001842633

PubMed

Title	Date	PubMed
Non-stimulant treatment for Attention-Deficit/Hyperactivity Disorder.	2002	12685525
Cardiovascular effects of atomoxetine in children, adolescents, and adults.	2003	12862507
Atomoxetine.	2003	12765489
Pharmacologic treatment approaches for children and adolescents with posttraumatic stress disorder.	2003 Apr	12725011
Pharmacological treatments for ADHD and the novel agent atomoxetine.	2003 Aug	13677007
Atomoxetine: a selective noradrenaline reuptake inhibitor for the treatment of attention-deficit/hyperactivity disorder.	2003 Jul	12831341
Strattera approved to treat ADHD.	2003 Mar-Apr	12715751
Gateways to clinical trials.	2003 May	12808477
Atomoxetine for attention deficit/hyperactivity disorder.	2003 May	12751480
Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential.	2003 Sep	12768267
Atomoxetine pharmacokinetics in children and adolescents with attention deficit hyperactivity disorder.	2003 Spring	12804126
Non-stimulant medications in the treatment of ADHD.	2004	15322961
Involvement of norepinephrine in the control of activity and attentive processes in animal models of attention deficit hyperactivity disorder.	2004	15303310
Spotlight on atomoxetine in adults with attention-deficit hyperactivity disorder.	2004	15089111
Impact of ADHD and its treatment on substance abuse in adults.	2004	15046534
ADHD treatment across the life cycle.	2004	15046532
Seizures and prolonged QTc with atomoxetine overdose.	2004 Apr	15056530
Role of presynaptic alpha2-adrenoceptors in antidepressant action: recent findings from microdialysis studies.	2004 Aug	15363606
Atomoxetine, a novel treatment for attention-deficit-hyperactivity disorder.	2004 Aug	15338851
Improvement in health-related quality of life in children with ADHD: an analysis of placebo controlled studies of atomoxetine.	2004 Aug	15308927
Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial kappa-opioid agonist effect.	2004 Aug 2	15225731
[Tourette syndrome: an analysis of its comorbidity and specific treatment].	2004 Feb	15011166
The use of atomoxetine adjunctively in fibromyalgia syndrome.	2004 Jul	15362262
Attention-deficit/hyperactivity disorder: medication treatment-dosing and duration of action.	2004 Jul	15352536
Once-daily atomoxetine treatment for children with attention-deficit/hyperactivity disorder, including an assessment of evening and morning behavior: a double-blind, placebo-controlled trial.	2004 Jul	15231966
Relapse prevention in pediatric patients with ADHD treated with atomoxetine: a randomized, double-blind, placebo-controlled study.	2004 Jul	15213591
The link between health-related quality of life and clinical symptoms among children with attention-deficit hyperactivity disorder.	2004 Jun	15194901
Acute oxcarbazepine and atomoxetine overdose with quetiapine.	2004 Jun	15171487
Pharmacological management of attention-deficit hyperactivity disorder.	2004 Jun	15163276
Nonstimulant treatment of adult attention-deficit/hyperactivity disorder.	2004 Jun	15064003
Driving impairments in teens and adults with attention-deficit/hyperactivity disorder.	2004 Jun	15063996
New drugs of 2003.	2004 Mar-Apr	15098851
[Attention-deficit/hyperactivity disorder (ADHS) in adulthood].	2004 Mar-Apr	15037976
Atomoxetine--treatment of attention deficit hyperactivity disorder: beyond stimulants.	2004 May	15319800
Atomoxetine hydrochloride.	2004 May	15152632
Potential noradrenergic targets for cognitive enhancement in schizophrenia.	2004 May	15115947
Adrenergic alpha 2C receptor genomic organization: association study in adult ADHD.	2004 May 15	15108182
New drugs for the treatment of attention-deficit/hyperactivity disorder.	2004 Nov	15571486
Combining stimulants with monoamine oxidase inhibitors: a review of uses and one possible additional indication.	2004 Nov	15554766
Atomoxetine: the first nonstimulant for the management of attention-deficit/hyperactivity disorder.	2004 Nov 15	15581262
A lifetime of distractions. ADHD is no longer just a children's disease. Many adults are being diagnosed and treated for the condition.	2004 Oct	15496372
Mania induction associated with atomoxetine.	2004 Oct	15349024
Management of hyperactivity and other acting-out problems in patients with autism spectrum disorder.	2004 Sep	15575418
Gateways to clinical trials.	2004 Sep	15538546
Aggression, mania, and hypomania induction associated with atomoxetine.	2004 Sep	15342872
Atomoxetine and nonresponders to stimulants.	2004 Sep	15337674
Atomoxetine and tics in ADHD.	2004 Sep	15322408
Evaluation of the reinforcing effects of atomoxetine in monkeys: comparison to methylphenidate and desipramine.	2004 Sep 6	15283948
Atomoxetine and stimulants in combination for treatment of attention deficit hyperactivity disorder: four case reports.	2004 Spring	15142400
Evaluation of the reinforcing effects of monoamine reuptake inhibitors under a concurrent schedule of food and i.v. drug delivery in rhesus monkeys.	2005 Apr	15526000

Patents

Sample Use Guides

In Vivo Use Guide

Atomoxetine should be initiated at a total daily dose of approximately 0.5 mg/kg and increased after a minimum of 3 days to a target total daily dose of approximately 1.2 mg/kg administered either as a single daily dose in the morning or as evenly divided doses in the morning and late afternoon/early evening. No additional benefit has been demonstrated for doses higher than 1.2 mg/kg/day.

Route of Administration: Oral

In Vitro Use Guide

Electrophysiological recordings was performed with the extracellular standard solution at different membrane potentials ranging from -80 mV to +40 mV while the concentration of the agonists (100 uM NMDA/10 uM glycine) and the antagonist (25 uM atomoxetine) were kept constant. The inhibitory effect was clearly voltage-dependent, so that the inhibition was attenuated by depolarization.

Substance Class	Chemical Created by `admin` on `Fri Jun 25 21:08:15 UTC 2021` Edited by `admin` on `Fri Jun 25 21:08:15 UTC 2021`
Record UNII	57WVB6I2W0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ATOMOXETINE HYDROCHLORIDE

Official Name

English

NSC-759104

Code

English

ATOMOXETINE HCL [VANDF]

Common Name

English

(-)-N-METHYL-3-PHENYL-3-(O-TOLYLOXY)PROPYLAMINE HYDROCHLORIDE

Systematic Name

English

ATOMOXETINE HYDROCHLORIDE [EP MONOGRAPH]

Common Name

English

ATOMOXETINE HCL

Common Name

English

ATOMOXETINE HYDROCHLORIDE [USP-RS]

Common Name

English

ATOMOXETINE HYDROCHLORIDE [WHO-DD]

Common Name

English

ATOMOXETINE HYDROCHLORIDE [JAN]

Common Name

English

LY-139603

Code

English

ATOMOXETINE HYDROCHLORIDE [USP MONOGRAPH]

Common Name

English

ATOMOXETINE (AS HYDROCHLORIDE)

Common Name

English

TOMOXETINE HYDROCHLORIDE

Common Name

English

ATOMOXETINE HYDROCHLORIDE [MI]

Common Name

English

STRATTERA

Brand Name

English

ATOMOXETINE HYDROCHLORIDE [MART.]

Common Name

English

ATOMOXETINE HYDROCHLORIDE [ORANGE BOOK]

Common Name

English

BENZENEPROPANAMINE, N-METHYL-.GAMMA.-(2-METHYLPHENOXY)-, HYDROCHLORIDE, (-)

Common Name

English

ATOMOXETINE HYDROCHLORIDE [USAN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

173003