Boserolimab

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 22:32:09 GMT 2025` Edited by `admin` on `Tue Apr 01 22:32:09 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	576SCZ7V2P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Boserolimab

Official Name

English

MK-5890

Preferred Name

English

boserolimab [INN]

Common Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN CD27 ANTIGEN) (HUMAN-MUS MUSCULUS CLONE 131A6 .GAMMA.1-CHAIN)

Common Name

English

BOSEROLIMAB [USAN]

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens CD27 (TNFRSF7, tumor necrosis factor receptor (TNFR) superfamily member 7)]

Common Name

English

MK 5890 [WHO-DD]

Common Name

English

gamma1 heavy chain (1-446) [VH (Homo sapiens IGHV1-2*02 (79.6%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.8.9] (26- 33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*01, G1m17,1 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 (230- 339), CH3 D12 (355), L14

Common Name

English

MK5890

Code

English

Code System Code Type Description

INN

11948

Created by admin on Tue Apr 01 22:32:09 GMT 2025 , Edited by admin on Tue Apr 01 22:32:09 GMT 2025

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FDA UNII

576SCZ7V2P

Created by admin on Tue Apr 01 22:32:09 GMT 2025 , Edited by admin on Tue Apr 01 22:32:09 GMT 2025

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CAS

2444297-08-7

Created by admin on Tue Apr 01 22:32:09 GMT 2025 , Edited by admin on Tue Apr 01 22:32:09 GMT 2025

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CAS

2209116-30-1

Created by admin on Tue Apr 01 22:32:09 GMT 2025 , Edited by admin on Tue Apr 01 22:32:09 GMT 2025

MAJOR COMPONENT STRUCTURE/SEQUENCE

SMS_ID

300000023311

Created by admin on Tue Apr 01 22:32:09 GMT 2025 , Edited by admin on Tue Apr 01 22:32:09 GMT 2025

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USAN

HI-229

Created by admin on Tue Apr 01 22:32:09 GMT 2025 , Edited by admin on Tue Apr 01 22:32:09 GMT 2025

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NCI_THESAURUS

C172056

Created by admin on Tue Apr 01 22:32:09 GMT 2025 , Edited by admin on Tue Apr 01 22:32:09 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_143	2_199
2_219	4_213
2_260	2_320
1_143	1_199
2_366	2_424
3_23	3_87
3_133	3_193
4_23	4_87
4_133	4_193
1_219	3_213
1_225	2_225
1_228	2_228
1_260	1_320
1_366	1_424

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					NJG4CJ69BB

TARGET -> AGONIST

Amount:

Related Record Type Details


					576SCZ7V2P

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_446] [2_446]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL