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Description

Corticorelin ovine is an analogue of the naturally occurring human corticotropin-releasing hormone (hCRH) peptide. Corticorelin ovine is a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. ACTH stimulates cortisol production from the adrenal cortex. Corticorelin ovine was marketed under the brand name ACTHREL for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing’s syndrome.

Approval Year

1996
225

Targets

Primary TargetPharmacologyConditionPotency
Corticotropin-releasing factor receptor 1
3
Binding Agent
1,064

Conditions

ConditionModalityTargetsHighest PhaseProduct
ACTH-dependent Cushing’s syndrome
2
 Diagnostic
Approved
8,429
ACTHREL

Sample Use Guides

In Vivo Use Guide
A single intravenous dose of ACTHREL® (corticorelin ovine) at 1 mcg/kg is recommended for the testing of pituitary corticotrophin function. A dose of 1 mcg/kg is the lowest dose that produces maximal cortisol responses and significant (though apparently sub-maximal) ACTH responses. Doses above 1 mcg/kg are not recommended.
Route of Administration: Intravenous
Substance Class Protein
Protein Sub Type
Record UNII
56X54T817Q
Record Status Validated (UNII)
Record Version
Subunit 0

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