U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Corticorelin ovine is an analogue of the naturally occurring human corticotropin-releasing hormone (hCRH) peptide. Corticorelin ovine is a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. ACTH stimulates cortisol production from the adrenal cortex. Corticorelin ovine was marketed under the brand name ACTHREL for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing’s syndrome.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P34998
Gene ID: 104909134|||1394
Gene Symbol: CRHR1
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
ACTHREL

Approved Use

ACTHREL® is indicated for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing’s syndrome.

Launch Date

8.3272322E11

Sample Use Guides

A single intravenous dose of ACTHREL® (corticorelin ovine) at 1 mcg/kg is recommended for the testing of pituitary corticotrophin function. A dose of 1 mcg/kg is the lowest dose that produces maximal cortisol responses and significant (though apparently sub-maximal) ACTH responses. Doses above 1 mcg/kg are not recommended.
Route of Administration: Intravenous
Substance Class Protein
Created
by admin
on Sun Dec 18 02:21:15 UTC 2022
Edited
by admin
on Sun Dec 18 02:21:15 UTC 2022
Protein Sub Type
Record UNII
56X54T817Q
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CORTICORELIN OVINE TRIFLUTATE
ORANGE BOOK   USAN   VANDF  
USAN  
Official Name English
CORTICORELIN [MART.]
Common Name English
Corticotropin-releasing factor (sheep), trifluoroacetate (salt)
Common Name English
CORTICORELIN OVINE TRIFLUTATE [USAN]
Common Name English
CORTICORELIN OVINE TRIFLUTATE [ORANGE BOOK]
Common Name English
CORTICORELIN TRIFLUTATE [MART.]
Common Name English
ACTHREL
Brand Name English
CORTICORELIN OVINE TRIFLUTATE [VANDF]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C394
Created by admin on Sun Dec 18 02:21:15 UTC 2022 , Edited by admin on Sun Dec 18 02:21:15 UTC 2022
FDA ORPHAN DRUG 35089
Created by admin on Sun Dec 18 02:21:15 UTC 2022 , Edited by admin on Sun Dec 18 02:21:15 UTC 2022
Code System Code Type Description
DRUG BANK
DB09067
Created by admin on Sun Dec 18 02:21:15 UTC 2022 , Edited by admin on Sun Dec 18 02:21:15 UTC 2022
PRIMARY
FDA UNII
56X54T817Q
Created by admin on Sun Dec 18 02:21:15 UTC 2022 , Edited by admin on Sun Dec 18 02:21:15 UTC 2022
PRIMARY
CAS
121249-14-7
Created by admin on Sun Dec 18 02:21:15 UTC 2022 , Edited by admin on Sun Dec 18 02:21:15 UTC 2022
PRIMARY
EVMPD
SUB129331
Created by admin on Sun Dec 18 02:21:15 UTC 2022 , Edited by admin on Sun Dec 18 02:21:15 UTC 2022
PRIMARY
RXCUI
74670
Created by admin on Sun Dec 18 02:21:15 UTC 2022 , Edited by admin on Sun Dec 18 02:21:15 UTC 2022
PRIMARY RxNorm
ChEMBL
CHEMBL1201591
Created by admin on Sun Dec 18 02:21:15 UTC 2022 , Edited by admin on Sun Dec 18 02:21:15 UTC 2022
PRIMARY
PUBCHEM
121494108
Created by admin on Sun Dec 18 02:21:15 UTC 2022 , Edited by admin on Sun Dec 18 02:21:15 UTC 2022
PRIMARY
EVMPD
SUB23368
Created by admin on Sun Dec 18 02:21:15 UTC 2022 , Edited by admin on Sun Dec 18 02:21:15 UTC 2022
PRIMARY
DAILYMED
56X54T817Q
Created by admin on Sun Dec 18 02:21:15 UTC 2022 , Edited by admin on Sun Dec 18 02:21:15 UTC 2022
PRIMARY
NCI_THESAURUS
C47463
Created by admin on Sun Dec 18 02:21:15 UTC 2022 , Edited by admin on Sun Dec 18 02:21:15 UTC 2022
PRIMARY
Related Record Type Details
STARTING MATERIAL -> INGREDIENT
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL