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Details

Stereochemistry MIXED
Molecular Formula C14H19N3O.2C12H19NO3
Molecular Weight 695.8885
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of QUINETOLATE

SMILES

CCN(CC)C(=O)C1CC=CCC1C(O)=O.CCN(CC)C(=O)C2CC=CCC2C(O)=O.COC3=CC4=C(C=C3)N=CC=C4NCCN(C)C

InChI

InChIKey=IYQFWDZTTDVVBP-UHFFFAOYSA-N
InChI=1S/C14H19N3O.2C12H19NO3/c1-17(2)9-8-16-14-6-7-15-13-5-4-11(18-3)10-12(13)14;2*1-3-13(4-2)11(14)9-7-5-6-8-10(9)12(15)16/h4-7,10H,8-9H2,1-3H3,(H,15,16);2*5-6,9-10H,3-4,7-8H2,1-2H3,(H,15,16)

HIDE SMILES / InChI
Molecular Formula C14H19N3O
Molecular Weight 245.3202
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C12H19NO3
Molecular Weight 225.2842
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Quinetolate is a quinolone derivative patented by The Geschickter Fund for Medical Research, Inc. for the treatment of bronchial asthma. In preclinical studies, Quinetolate antagonized the effect of histamine on the lung in rabbits and blocked arrhythmias induced by chloroform in mice. Quinetholate shows potent antiarrhythmic activities on ouabain-induced tachycardia. Quinetholate caused the longest lasting reversions of ouabain-induced tachycardia, i.e. usually lasting at least 30 min after infusion was stopped.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Cardiopulmonary effects of antimalarial drugs. 1. 4-Aminoquinolines: chloroquine quinetholate.
1970 Jul
Bromocriptine treatment of digitalis-induced ventricular tachyarrhythmias: studies in a canine model.
1984 Dec
Patents

Patents

20070116729
157
2721867
1
WO2010024870A1
59
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:45:08 GMT 2023
Edited
by admin
on Fri Dec 15 18:45:08 GMT 2023
Record UNII
56UTZ1RCNO
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
QUINETOLATE
USAN  
USAN  
Official Name English
QUINETOLATE [USAN]
Common Name English
quinetalate [INN]
Common Name English
QUINETALATE
INN  
INN  
Official Name English
Classification Tree Code System Code
NCI_THESAURUS C29712
Created by admin on Fri Dec 15 18:45:08 GMT 2023 , Edited by admin on Fri Dec 15 18:45:08 GMT 2023
Code System Code Type Description
FDA UNII
56UTZ1RCNO
Created by admin on Fri Dec 15 18:45:08 GMT 2023 , Edited by admin on Fri Dec 15 18:45:08 GMT 2023
PRIMARY
ECHA (EC/EINECS)
227-207-0
Created by admin on Fri Dec 15 18:45:08 GMT 2023 , Edited by admin on Fri Dec 15 18:45:08 GMT 2023
PRIMARY
MESH
C017700
Created by admin on Fri Dec 15 18:45:08 GMT 2023 , Edited by admin on Fri Dec 15 18:45:08 GMT 2023
PRIMARY
NCI_THESAURUS
C152123
Created by admin on Fri Dec 15 18:45:08 GMT 2023 , Edited by admin on Fri Dec 15 18:45:08 GMT 2023
PRIMARY
INN
2112
Created by admin on Fri Dec 15 18:45:08 GMT 2023 , Edited by admin on Fri Dec 15 18:45:08 GMT 2023
PRIMARY
EPA CompTox
DTXSID30972605
Created by admin on Fri Dec 15 18:45:08 GMT 2023 , Edited by admin on Fri Dec 15 18:45:08 GMT 2023
PRIMARY
PUBCHEM
21947
Created by admin on Fri Dec 15 18:45:08 GMT 2023 , Edited by admin on Fri Dec 15 18:45:08 GMT 2023
PRIMARY
CAS
5714-76-1
Created by admin on Fri Dec 15 18:45:08 GMT 2023 , Edited by admin on Fri Dec 15 18:45:08 GMT 2023
PRIMARY
EVMPD
SUB10212MIG
Created by admin on Fri Dec 15 18:45:08 GMT 2023 , Edited by admin on Fri Dec 15 18:45:08 GMT 2023
PRIMARY
SMS_ID
100000080296
Created by admin on Fri Dec 15 18:45:08 GMT 2023 , Edited by admin on Fri Dec 15 18:45:08 GMT 2023
PRIMARY
NIH
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