LONIGUTAMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:32:06 GMT 2025` Edited by `admin` on `Wed Apr 02 11:32:06 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Type	COMPLETE
Record UNII	56GN9PT35D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LONIGUTAMAB

Official Name

English

VB-421

Preferred Name

English

lonigutamab [INN]

Common Name

English

IMMUNOGLOBULIN G1 (DE-C-TERMINAL-LYSINE), ANTI-(HUMAN INSULIN-LIKE GROWTH FACTOR I RECEPTOR) (HUMAN-MUS MUSCULUS MONOCLONAL HZ208F2-4 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL HZ208F2-4 .KAPPA.-CHAIN, DIMER

Common Name

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS IGF1R (INSULIN LIKE GROWTH FACTOR 1 RECEPTOR, IGF1-R, IGF-1R, CD221)), HUMANIZED MONOCLONAL ANTIBODY

Common Name

English

VB421

Code

English

Code System Code Type Description

NCI_THESAURUS

C184844

Created by admin on Wed Apr 02 11:32:06 GMT 2025 , Edited by admin on Wed Apr 02 11:32:06 GMT 2025

PRIMARY

SMS_ID

300000038058

Created by admin on Wed Apr 02 11:32:06 GMT 2025 , Edited by admin on Wed Apr 02 11:32:06 GMT 2025

PRIMARY

CAS

2362015-67-4

Created by admin on Wed Apr 02 11:32:06 GMT 2025 , Edited by admin on Wed Apr 02 11:32:06 GMT 2025

PRIMARY

FDA UNII

56GN9PT35D

Created by admin on Wed Apr 02 11:32:06 GMT 2025 , Edited by admin on Wed Apr 02 11:32:06 GMT 2025

PRIMARY

INN

11639

Created by admin on Wed Apr 02 11:32:06 GMT 2025 , Edited by admin on Wed Apr 02 11:32:06 GMT 2025

PRIMARY

INN

From	To
1_22	1_96
2_22	2_96
2_147	2_203
2_223	4_214
2_264	2_324
1_147	1_203
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_223	3_214
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					VJ9X8A8CJ5

LONIGUTAMAB UGODOTIN

CONJUGATE -> PARENT

Amount:


					DK7PL4F3TT

INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR

TARGET->LIGAND

Amount:

Related Record Type Details


					56GN9PT35D

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]				PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL
Molecular Formula	CHEMICAL