Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C36H56O9 |
| Molecular Weight | 632.8244 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 15 / 15 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]6(O[C@H]1CC[C@@]2(C)[C@@]([H])(CC[C@]3(C)[C@]2([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C(O)=O)C(O)=O)C1(C)C)O[C@H](C)[C@@H](O)[C@H](O)[C@H]6O
InChI
InChIKey=PUOQHFWXBKTHST-DLCGLXBKSA-N
InChI=1S/C36H56O9/c1-18-10-15-35(30(40)41)16-17-36(31(42)43)21(25(35)19(18)2)8-9-23-33(6)13-12-24(32(4,5)22(33)11-14-34(23,36)7)45-29-28(39)27(38)26(37)20(3)44-29/h8,18-20,22-29,37-39H,9-17H2,1-7H3,(H,40,41)(H,42,43)/t18-,19+,20-,22+,23-,24+,25+,26-,27+,28-,29+,33+,34-,35+,36-/m1/s1
| Molecular Formula | C36H56O9 |
| Molecular Weight | 632.8244 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 15 / 15 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/12135095 | https://www.ncbi.nlm.nih.gov/pubmed/12462343
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/12135095 | https://www.ncbi.nlm.nih.gov/pubmed/12462343
Quinovin is a glucoside isolated from bark of Cortex chinae and Mitragyna stipulosa. Quinovin is a mixture of three glycosides, 60% A (Quinovic acid b-D-quinovoside), 5% B (Cincholic acid b-D-quinovoside) and 30% C (Quinovic acid b-D-glucoside). Quinovine was shown to inhibit PDE1 from snake venom in submillimolar concentrations.
Approval Year
Sample Use Guides
Activity against snake venom phosphodiesterase I (Sigma P 4631) (EC 3.1.4.1) was assayed.
33mM tris-HCl buffer pH 8.8 containing 30mM Mg(C2H3O2)2 4H2O with 0.000742 U/well final concentration was prepared using microtiter plate, and 0.33mM bis-( p-nitrophenyl) phosphate was used as a substrate. Quinovine was added, and after 30 min incubation the enzyme activity was monitored spectrophotometrically at 37C on a microtitre plate reader by following the release of p-nitrophenol from p-nitrophenyl phosphate at 410 nm.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:03:45 GMT 2023
by
admin
on
Sat Dec 16 09:03:45 GMT 2023
|
| Record UNII |
5655DJH94B
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
53516-73-7
Created by
admin on Sat Dec 16 09:03:45 GMT 2023 , Edited by admin on Sat Dec 16 09:03:45 GMT 2023
|
SUPERSEDED | |||
|
107870-05-3
Created by
admin on Sat Dec 16 09:03:45 GMT 2023 , Edited by admin on Sat Dec 16 09:03:45 GMT 2023
|
PRIMARY | |||
|
5655DJH94B
Created by
admin on Sat Dec 16 09:03:45 GMT 2023 , Edited by admin on Sat Dec 16 09:03:45 GMT 2023
|
PRIMARY | |||
|
11411086
Created by
admin on Sat Dec 16 09:03:45 GMT 2023 , Edited by admin on Sat Dec 16 09:03:45 GMT 2023
|
PRIMARY | |||
|
m9463
Created by
admin on Sat Dec 16 09:03:45 GMT 2023 , Edited by admin on Sat Dec 16 09:03:45 GMT 2023
|
PRIMARY | Merck Index |