Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C10H16N2O2.H2O |
| Molecular Weight | 214.2615 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O=C([C@H]1CCC(=O)N1)N2CCCCC2
InChI
InChIKey=YUBYMONBCDIKAB-DDWIOCJRSA-N
InChI=1S/C10H16N2O2.H2O/c13-9-5-4-8(11-9)10(14)12-6-2-1-3-7-12;/h8H,1-7H2,(H,11,13);1H2/t8-;/m1./s1
| Molecular Formula | C10H16N2O2 |
| Molecular Weight | 196.2462 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including, https://www.nootropics.eu/a-review-on-the-benefits-of-fasoracetam/
Curator's Comment: description was created based on several sources, including, https://www.nootropics.eu/a-review-on-the-benefits-of-fasoracetam/
Fasoracetam is a cognition enhancer that interacts with GABA(B) receptors, stimulates neuronal ACh receptors and modulates mGlu receptors. The drug is being tested in phase III/II of clinical trials for the treatment of Attention Deficit Disorder With Hyperactivity in people with genetic disorders impacting mGlu receptors and never been approved by FDA. Fasoracetam is also being marketed in the form of capsules for research purposes aimed at investigation of cognition and memory disorders.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2111463 |
|||
Target ID: Acetylcholine receptor |
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Target ID: Metabotropic glutamate receptors Sources: http://www.medgenics.com/c/pipeline/ |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Involvement of metabotropic glutamate receptors in Gi- and Gs-dependent modulation of adenylate cyclase activity induced by a novel cognition enhancer NS-105 in rat brain. | 1997 Apr 18 |
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| A novel cognition enhancer NS-105 modulates adenylate cyclase activity through metabotropic glutamate receptors in primary neuronal culture. | 1997 Aug |
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| Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: possible involvement of GABA(B) receptor up-regulation after repeated treatment. | 1997 Nov 12 |
|
| Comparison of pharmacokinetics of NS-105, a novel agent for cerebrovascular disease, in elderly and young subjects. | 1999 |
|
| Fasoracetam. LAM 105, NS 105. | 1999 Aug |
|
| Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer. | 1999 Sep |
Patents
Sample Use Guides
100, 200, or 400 mg twice daily as capsules for oral administration.
Route of Administration:
Oral
Fasoracetam (10(-7) and 10(-6) M) inhibited forskolin-stimulated cyclic AMP formation in cultured neurons of the mouse cerebral cortex. Conversely, in pertussis toxin-pretreated neurons, the drug (10(-7)-10(-5) M) significantly enhanced the forskolin-stimulated cyclic AMP formation, and this action was completely reversed by cholera toxin.
| Substance Class |
Chemical
Created
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| Record UNII |
55BRM1BEZN
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| Record Status |
Validated (UNII)
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ACTIVE MOIETY |