U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

2024
711
Substance Class Protein
Created
by admin
on Wed Apr 02 17:23:29 GMT 2025
Edited
by admin
on Wed Apr 02 17:23:29 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
557S3L3FAP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Pemivibart
INN  
Official Name English
Immunoglobulin G1 [435-leucine,441-alanine], anti-(severe acute respiratory syndrome coronavirus 2 spike glycoprotein receptor-binding domain) (human monoclonal VYD222 ?1-chain), disulfide with human monoclonal VYD222 ?2-chain, dimer
Preferred Name English
PEMIVIBART [USAN]
Common Name English
gamma1 heavy chain Homo sapiens (1-454) [VH (Homo sapiens IGHV3-21*07 (88.8%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.17] (26-33.51-58.97-113)) (1-124) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v78 L107, A114 (CH1 R120 (221) (125-222
Common Name English
immunoglobulin G1-lambda2, anti-[severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein, receptor binding domain (RBD)], Homo sapiens monoclonal antibody
Common Name English
pemivibart [INN]
Common Name English
Immunoglobulin G1-lambda2, anti-[severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein, receptor binding domain (RBD)], Homo sapiens monoclonal antibody; gamma1 heavy chain Homo sapiens (1-454) [VH (Homo sapiens IGHV3-21*07 (88.8
Common Name English
Pemivibart [WHO-DD]
Common Name English
Code System Code Type Description
INN
13017
Created by admin on Wed Apr 02 17:23:29 GMT 2025 , Edited by admin on Wed Apr 02 17:23:29 GMT 2025
PRIMARY
DAILYMED
557S3L3FAP
Created by admin on Wed Apr 02 17:23:29 GMT 2025 , Edited by admin on Wed Apr 02 17:23:29 GMT 2025
PRIMARY
FDA UNII
557S3L3FAP
Created by admin on Wed Apr 02 17:23:29 GMT 2025 , Edited by admin on Wed Apr 02 17:23:29 GMT 2025
PRIMARY
SMS_ID
300000049475
Created by admin on Wed Apr 02 17:23:29 GMT 2025 , Edited by admin on Wed Apr 02 17:23:29 GMT 2025
PRIMARY
USAN
MN-184
Created by admin on Wed Apr 02 17:23:29 GMT 2025 , Edited by admin on Wed Apr 02 17:23:29 GMT 2025
PRIMARY
CAS
2858673-18-2
Created by admin on Wed Apr 02 17:23:29 GMT 2025 , Edited by admin on Wed Apr 02 17:23:29 GMT 2025
PRIMARY
NCI_THESAURUS
C203086
Created by admin on Wed Apr 02 17:23:29 GMT 2025 , Edited by admin on Wed Apr 02 17:23:29 GMT 2025
PRIMARY
USAN
MN-184
Created by admin on Wed Apr 02 17:23:29 GMT 2025 , Edited by admin on Wed Apr 02 17:23:29 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_151 2_207
2_227 4_217
2_268 2_328
1_151 1_207
2_374 2_432
3_22 3_90
3_140 3_199
4_22 4_90
4_140 4_199
1_227 3_217
1_233 2_233
1_236 2_236
1_268 1_328
1_374 1_432
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_304
N 2_304
Related Record Type Details
Pemivibart
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID REMOVAL [1_454] [2_454] C-TERMINUS Amount: LYSINE K3Z4F929H6
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS E Amount: PIDOLIC ACID SZB83O1W42
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
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