Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H10NO3.Na |
Molecular Weight | 275.2346 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[O-]C(=O)CN1C2=C(C=CC=C2)C(=O)C3=C1C=CC=C3
InChI
InChIKey=FQMLTEAEJZVTAJ-UHFFFAOYSA-M
InChI=1S/C15H11NO3.Na/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16;/h1-8H,9H2,(H,17,18);/q;+1/p-1
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C15H10NO3 |
Molecular Weight | 252.2448 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.xeneticbio.com/news-media/press-releases/detail/38/xenetic-biosciences-announces-fda-acceptance-ofCurator's Comment: The description was created based on several sources, including
https://clinicaltrials.gov/ct2/show/NCT02064725 | https://clinicaltrials.gov/ct2/show/NCT03077698
Sources: https://www.xeneticbio.com/news-media/press-releases/detail/38/xenetic-biosciences-announces-fda-acceptance-of
Curator's Comment: The description was created based on several sources, including
https://clinicaltrials.gov/ct2/show/NCT02064725 | https://clinicaltrials.gov/ct2/show/NCT03077698
Cridanimod (Virexxa) is a small-molecule immunomodulator and interferon inducer, which, in preliminary studies, has been shown to increase progesterone receptor expression in endometrial tissue. Restoration of progesterone receptor expression may re-sensitize endometrial tumor tissue to progestin therapy in previously unresponsive tumors. Cridanimod was originally developed by Polysan and Pharmsynthez and licensed to Xenetic Biosciences. Virexxa is currently being studied in an ongoing Phase 2 multi-national study in conjunction with progestin therapy for the treatment of endometrial cancer in women with the recurrent or persistent disease who have failed progestin monotherapy.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
HIV-1 neutralization and tumor cell proliferation inhibition in vitro by simplified analogues of pyrido[4,3,2-mn]thiazolo[5,4-b]acridine marine alkaloids. | 1992 Jul 24 |
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[Increase in NK-activity using superlow doses of the immunomodulator cycloferon]. | 2001 |
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Correlations between in vitro effects of preparations of interferon and its inducers on blood cells in patients with multiple sclerosis. | 2001 Apr |
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[Effect of interferon inductors on infection induced by hepatitis C virus and activity of mRNA cytokines in cell cultures SW-13 and MT-4]. | 2002 Nov-Dec |
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Direct antiviral effect of cycloferon (10-carboxymethyl-9-acridanone) against adenovirus type 6 in vitro. | 2003 Apr |
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[Use of cycloferon in a combined treatment of chlamydial conjunctivitis]. | 2003 Jan-Feb |
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[Neuroimmunopathologic aspects of epilepsy]. | 2004 |
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[The preclinical diagnosis, prevention and treatment of postoperative iridocyclitis in patients after intraocular aphakia correction]. | 2004 Jul-Aug |
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[Cycloferon--a new domestic preparation for the prophylaxis of influenza and other acute respiratory viral infections]. | 2004 Nov-Dec |
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[Cyclopheron pretreatment in opisthorchiasis management in patients with viral hepatitis C]. | 2005 |
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[Influence of cycloferon on the biological properties of bacterial intracellular pathogens]. | 2005 May-Jun |
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Structural, spectroscopic, and magnetic study of bis(9,10-dihydro-9-oxo-10-acridineacetate)bis(imidazole)bis(methanol) nickel(II). | 2006 Dec 25 |
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[Effect of intranasal aerosol-therapy with cycloferon on the function of respiration in patients with some forms of rhinitis]. | 2007 Jan |
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[Cycloferon in the treatment of infectious diseases]. | 2008 |
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[Immunomodulators in the "gold standard" of the chronic viral hepatitis C therapy]. | 2008 |
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[Improvement of natural resistance in children for prophylaxis of influenza and acute respiratory tract viral infections (results of multicenter randomized trials)]. | 2009 |
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[Up-to-date approach to treatment of inflammatory infections in the maxillofacial region]. | 2009 |
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[Cycloferon efficacy in viral and bacterial diseases of children (clinical review)]. | 2010 |
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[Optimization of prophylaxis of relapses of primary erysipelas with the use of cyclopheron]. | 2010 |
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[Use of cycloferon in the treatment of patients with pulmonary tuberculosis with mild clinical manifestations]. | 2010 |
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[Efficiency of using cycloferon as part of combined therapy for chronic hepatitis C (a review of multicenter clinical trials)]. | 2010 |
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[The cytokine profile in the acute period of tick-borne neuroinfections in children]. | 2010 |
|
[Clinical laboratory approaches to parodontitis treatment optimization]. | 2010 |
|
[Effectiveness of cycloferon liniment in a complex treatment, and monitoring of cytokine profile of gingival fluid of patients with paradontitis]. | 2010 |
|
[Optimization of parodontitis treatment of patients with tuberculosis]. | 2010 |
|
[Changes of functional activity of peripheral blood leukocytes during the immunotherapy of tick-borne infections in children]. | 2010 |
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[Cycloferon in complex therapy of chronic brucellosis]. | 2010 |
|
[The use of cycloferon in the combined treatment of tuberculosis patients infected with HIV and viral hepatitis]. | 2010 |
|
[Correction of immunity disorders, treatment of intestinal infections and disbiosis in children (clinical review)]. | 2010 |
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[Pathogenetically substantiated therapy of patients with virus hepatitis C, quality of life, and the disease outcome risk (clinical survey)]. | 2010 |
|
[Efficacy of cycloferon in the treatment of brucellosis]. | 2010 |
|
[Use of immunomodulators in the therapy of chronic hepatitis C: improving standard approach]. | 2010 Apr |
|
[Combined cycloferon treatment of tuberculosis in patients infected with HIV]. | 2010 Jul |
|
[Focal immunophysiotherapy in combined treatment of men with manifestations of papilloma virus infection]. | 2010 Nov-Dec |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT02064725
Eligible patients will be enrolled into the study and administered sodium cridanimod (500 mg i.m./ twice a week) in combination with megestrol acetate (160 mg p.o./ day) or medroxyprogesterone acetate (200 mg p.o./ day).
Route of Administration:
Intramuscular
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:48:47 GMT 2023
by
admin
on
Fri Dec 15 17:48:47 GMT 2023
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Record UNII |
54W868ROLR
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
267508
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NCI_THESAURUS |
C2140
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NCI_THESAURUS |
C308
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C114298
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58880-43-6
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DTXSID10932383
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100000076618
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SUB13209MIG
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54W868ROLR
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23684339
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144696-36-6
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351531-53-8
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |