4-METHYLHISTAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H11N3
Molecular Weight	125.1716
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC1=C(CCN)NC=N1

InChI

InChIKey=UGYXPZQILZRKJJ-UHFFFAOYSA-N

InChI=1S/C6H11N3/c1-5-6(2-3-7)9-4-8-5/h4H,2-3,7H2,1H3,(H,8,9)

HIDE SMILES / InChI

Molecular Formula	C6H11N3
Molecular Weight	125.1716
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H4 receptor 20	Agonist 2,678		31.62 nM [EC50]

PubMed

PubMed

Show entries

Title	Date	PubMed
Histamine regulation of interleukin-18-initiating cytokine cascade is associated with down-regulation of intercellular adhesion molecule-1 expression in human peripheral blood mononuclear cells.	2002 Jan	11752121
Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives.	2006 Apr	16432504
Histamine downregulates monocyte CCL2 production through the histamine H4 receptor.	2007 Aug	17507084
Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses.	2007 Jun	17346280
Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model.	2007 Jun 15	17548646

Showing 1 to 5 of 8 entries

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Substance Class	Chemical
Record UNII	54ST71P9EE
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

4-METHYLHISTAMINE

Systematic Name

English

1H-IMIDAZOLE-4-ETHANAMINE, 5-METHYL-

Systematic Name

English

4-(2-AMINOETHYL)-5-METHYLIMIDAZOLE

Systematic Name

English

2-(5-METHYL-4-IMIDAZOLYL)ETHYLAMINE

Systematic Name

English

1H-IMIDAZOLE-5-ETHANAMINE, 4-METHYL-

Systematic Name

English

Showing 1 to 5 of 7 entries

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Show entries

Code System

Code

Type

Description

CAS

36507-31-0

PRIMARY

PUBCHEM

37463

PRIMARY

MESH

C025566

PRIMARY

EPA CompTox

DTXSID90957812

PRIMARY

FDA UNII

54ST71P9EE

PRIMARY

Showing 1 to 5 of 6 entries

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