Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H11N3 |
| Molecular Weight | 125.1716 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=C(CCN)NC=N1
InChI
InChIKey=UGYXPZQILZRKJJ-UHFFFAOYSA-N
InChI=1S/C6H11N3/c1-5-6(2-3-7)9-4-8-5/h4H,2-3,7H2,1H3,(H,8,9)
| Molecular Formula | C6H11N3 |
| Molecular Weight | 125.1716 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The effect of intracerebroventricular injection of histamine in visceral nociception induced by acetic acid in rats. | 2010-10 |
|
| Histamine inhibits adhesion molecule expression in human monocytes, induced by advanced glycation end products, during the mixed lymphocyte reaction. | 2010-07 |
|
| Molecular determinants of ligand binding to H4R species variants. | 2010-05 |
|
| Histamine H(4) receptor antagonist ameliorates chronic allergic contact dermatitis induced by repeated challenge. | 2010-03 |
|
| Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands. | 2010-02 |
|
| Inhibition of basophil activation by histamine: a sensitive and reproducible model for the study of the biological activity of high dilutions. | 2009-10 |
|
| Histamine inhibits advanced glycation end products-induced adhesion molecule expression on human monocytes. | 2009-09 |
|
| Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430. | 2009-05 |
|
| Role of histamine H(4) receptor in allergic conjunctivitis in mice. | 2009-04-17 |
|
| The histamine H4 receptor is functionally expressed on T(H)2 cells. | 2009-03 |
|
| Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. | 2008-06-06 |
|
| Comparison of the effect of 4-methyl histamine on human and mouse basophil activation. | 2008 |
|
| Confirmation of biological effects of high dilutions. Effects of submolecular concentrations of histamine and 1-, 3- and 4-methylhistamines on human basophil activation. | 2008 |
|
| Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors. | 2007-09-01 |
|
| Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. | 2007-08 |
|
| Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. | 2007-06-15 |
|
| Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. | 2007-06 |
|
| Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. | 2006-04 |
|
| Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. | 2005-09 |
|
| Histamine downregulates CD14 expression via H2 receptors on human monocytes. | 2003-09 |
|
| Histamine inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in an intercellular adhesion molecule-1- and B7.1-dependent manner. | 2003-02 |
|
| Effect of histamine on intercellular adhesion molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18. | 2002-09-27 |
|
| Histamine H(2) -like receptors in chick cerebral cortex: effects on cyclic AMP synthesis and characterization by [(3) H]tiotidine binding. | 2002-06 |
|
| Histamine regulation of interleukin-18-initiating cytokine cascade is associated with down-regulation of intercellular adhesion molecule-1 expression in human peripheral blood mononuclear cells. | 2002-01 |
|
| Effects of histamine and related compounds on the differentiation of HL-60-Eo cells into eosinophils. | 2001-09 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:28:13 GMT 2025
by
admin
on
Mon Mar 31 19:28:13 GMT 2025
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| Record UNII |
54ST71P9EE
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| Record Status |
Validated (UNII)
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| Record Version |
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36507-31-0
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37463
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C025566
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DTXSID90957812
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54ST71P9EE
Created by
admin on Mon Mar 31 19:28:13 GMT 2025 , Edited by admin on Mon Mar 31 19:28:13 GMT 2025
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4-METHYLHISTAMINE
Created by
admin on Mon Mar 31 19:28:13 GMT 2025 , Edited by admin on Mon Mar 31 19:28:13 GMT 2025
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PRIMARY |