Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C12H14N4O3 |
Molecular Weight | 262.2646 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC=CC2=C1N=CN2[C@@H]3C=C(CO)[C@@H](O)[C@H]3O
InChI
InChIKey=OMKHWTRUYNAGFG-IEBDPFPHSA-N
InChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1
Molecular Formula | C12H14N4O3 |
Molecular Weight | 262.2646 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2189110 |
0.08 µM [IC50] | ||
Target ID: CHEMBL2664 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3790170 |
50.0 pM [Ki] | ||
Target ID: CHEMBL613493 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26314922 |
|||
Target ID: CHEMBL613731 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26314922 |
|||
Target ID: CHEMBL613126 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26314922 |
PubMed
Title | Date | PubMed |
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Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives. | 1989 Aug |
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Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities. | 1989 Jul |
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Inhibitory activity of S-adenosylhomocysteine hydrolase inhibitors against human cytomegalovirus replication. | 1993 Jul |
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Anti-human immunodeficiency virus 1 (HIV-1) activities of 3-deazaadenosine analogs: increased potency against 3'-azido-3'-deoxythymidine-resistant HIV-1 strains. | 1995 Jan 3 |
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S-adenosylhomocysteine hydrolase inhibitors interfere with the replication of human immunodeficiency virus type 1 through inhibition of the LTR transactivation. | 1997 Dec |
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Carbocyclic adenosine analogues as S-adenosylhomocysteine hydrolase inhibitors and antiviral agents: recent advances. | 1998 Jan-Mar |
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Carboxy terminal variants of Epstein-Barr virus-encoded latent membrane protein 1 during long-term human immunodeficiency virus infection: reliable markers for individual strain identification. | 1999 Jan |
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Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor. | 2000 Feb |
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Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections. | 2001 Apr |
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3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice. | 2002 Jul |
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Identification of active antiviral compounds against a New York isolate of West Nile virus. | 2002 Jul |
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Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. | 2003 Jan |
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Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. | 2003 Sep |
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Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine. | 2004 Jan |
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Disruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity. | 2013 Dec |
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Epigenetic silencing of microRNA-218 via EZH2-mediated H3K27 trimethylation is involved in malignant transformation of HBE cells induced by cigarette smoke extract. | 2016 Feb |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:39:58 GMT 2023
by
admin
on
Sat Dec 16 08:39:58 GMT 2023
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Record UNII |
544SH4020S
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Record Status |
Validated (UNII)
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Record Version |
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544SH4020S
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102052-95-9
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3-Deazaneplanocin A
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DTXSID30144562
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73087
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