Surzebiclimab

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 04:33:28 GMT 2025` Edited by `admin` on `Wed Apr 02 04:33:28 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	53YMC3A1CU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Immunoglobulin G1 [235-proline,236-alanine,237-alanine,de-239-glycine,331-alanine], anti-(human hepatitis A virus cellular receptor 2) (human-Mus musculus monoclonal BGB-A425 ?1-chain), disulfide with human-Mus musculus monoclonal BGB-A425 ?-chain, dimer

Preferred Name

English

Surzebiclimab

Official Name

English

BGB-A425

Code

English

surzebiclimab [INN]

Common Name

English

BGBA425

Code

English

SURZEBICLIMAB [USAN]

Common Name

English

BGB A425 [WHO-DD]

Common Name

English

ANTI-TIM-3 MONOCLONAL ANTIBODY BGB-A425

Common Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens HAVCR2 (hepatitis A virus cellular receptor 2, T-cell immunoglobulin mucin family member 3, Tim-3, TIM3, TIMD3, CD366)], monoclonal antibody; gamma1 heavy chain (1-448) [VH (Homo sapiens IGHV3-23*04 (93.8%) -(I

Common Name

English

Code System Code Type Description

SMS_ID

300000000321

Created by admin on Wed Apr 02 04:33:28 GMT 2025 , Edited by admin on Wed Apr 02 04:33:28 GMT 2025

PRIMARY

CAS

2342597-90-2

Created by admin on Wed Apr 02 04:33:28 GMT 2025 , Edited by admin on Wed Apr 02 04:33:28 GMT 2025

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NCI_THESAURUS

C157242

Created by admin on Wed Apr 02 04:33:28 GMT 2025 , Edited by admin on Wed Apr 02 04:33:28 GMT 2025

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NCIT

INN

11453

Created by admin on Wed Apr 02 04:33:28 GMT 2025 , Edited by admin on Wed Apr 02 04:33:28 GMT 2025

PRIMARY

INN

USAN

KL-130

Created by admin on Wed Apr 02 04:33:28 GMT 2025 , Edited by admin on Wed Apr 02 04:33:28 GMT 2025

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FDA UNII

53YMC3A1CU

Created by admin on Wed Apr 02 04:33:28 GMT 2025 , Edited by admin on Wed Apr 02 04:33:28 GMT 2025

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From	To
1_22	1_95
1_146	1_202
1_222	3_218
1_228	2_228
1_231	2_231
1_262	1_322
1_368	1_426
2_22	2_95
2_146	2_202
2_222	4_218
2_262	2_322
2_368	2_426
3_23	3_92
3_138	3_198
4_23	4_92
4_138	4_198

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					PBG9RMW5RU

HEPATITIS A VIRUS CELLULAR RECEPTOR 2

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					53YMC3A1CU

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_448] [2_448]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL