HYDROXYDIONE SODIUM SUCCINATE

First approved in 1955

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H35O6.Na
Molecular Weight	454.5316
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of HYDROXYDIONE SODIUM SUCCINATE

Structure Search

SMILES

[Na+].C[C@]12CC[C@H]3[C@@H](CC[C@@H]4CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)COC(=O)CCC([O-])=O

InChI

InChIKey=BFQDICGJHAONBN-OOFWROCWSA-M

InChI=1S/C25H36O6.Na/c1-24-11-9-16(26)13-15(24)3-4-17-18-5-6-20(25(18,2)12-10-19(17)24)21(27)14-31-23(30)8-7-22(28)29;/h15,17-20H,3-14H2,1-2H3,(H,28,29);/q;+1/p-1/t15-,17+,18+,19+,20-,24+,25+;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C25H35O6
Molecular Weight	431.5418
Charge	-1
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.hmdb.ca/metabolites/HMDB0062609 | https://www.ncbi.nlm.nih.gov/pubmed/13329402 | https://www.ncbi.nlm.nih.gov/pubmed/1156941

HYDROXYDIONE is a neuroactive steroid used formerly as a general anesthetic. It was discontinued due to a high incidence of post-anesthetic thrombophlebitis, delayed onset of anesthesia and an unacceptably long duration of action.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
pain 5 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13356183	Preventing		Approved 8583	Viadril Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
AAA Chemistry	AR-1D7886
ABI Chem	AC1L5X6T
ABI Chem	AC1Q6OLH
Chemieliva Pharmaceutical Co., Ltd	PBCM1266033
NCI Plated 2007	86000
NovoSeek	257630
THE BioTek	bt-432595	https://www.thebiotek.com/product/others/bt-432595
TimTec	ST50410049
Toronto Research Chemicals	H941558
ZINC	ZINC000004900230	http://zinc15.docking.org/substances/ZINC000004900230

PubMed

Title	Date	PubMed
Studies on the clinical and pathological effects of hydroxydione.	1961-10	14492824
Hydroxydione sodium (viadril) for anesthesia; a report of clinical experience.	1956-09	13356183
Viadril: a new steroid anaesthetic; preliminary communication.	1956-07-21	13329402
Steroid anesthetic agent.	1955-07-08	14385824

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:49:39 GMT 2025` Edited by `admin` on `Mon Mar 31 17:49:39 GMT 2025`
Record UNII	53J8I8O5EW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

21-(3-CARBOXY-1-OXOPROPOXY)-5-.BETA.-PREGNANE-3,20-DIONE SODIUM SALT

Preferred Name

English

HYDROXYDIONE SODIUM SUCCINATE

Official Name

English

VIADRIL

Brand Name

English

hydroxydione sodium succinate [INN]

Common Name

English

SODIUM HYDROXYDIONE

Common Name

English

21-HYDROXY-5-.BETA.-PREGNANE-3,20-DIONE, SODIUM SALT, HEMISUCCINATE

Common Name

English

HYDROXYDIONE SODIUM [MI]

Common Name

English

21-HYDROXY-5.BETA.-PREGNANE-3,20-DIONE 21-(SODIUM SUCCINATE)

Common Name

English

21-HYDROXY-5.BETA.-PREGNANE-3,20-DIONE SODIUM SUCCINATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C245