TRIBUFOS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H27OPS3
Molecular Weight	314.511
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CCCCSP(=O)(SCCCC)SCCCC

InChI

InChIKey=ZOKXUAHZSKEQSS-UHFFFAOYSA-N

InChI=1S/C12H27OPS3/c1-4-7-10-15-14(13,16-11-8-5-2)17-12-9-6-3/h4-12H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C12H27OPS3
Molecular Weight	314.511
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Tribufos is an organophosphate defoliant used for cotton crops. It is specifically used to defoliate cotton in preparation for machine harvesting. Tribufos inhibits CB1 in vivo, without cholinergic poisoning signs, by 50% at 50 mg/kg intraperitoneally with a recovery half-time of 3-4 days, indicating covalent derivatization.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cannabinoid CB1 receptor 85	Antagonist 2,849
Anandamide amidohydrolase 27	Inhibitor 8,504		52.0 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2,596

PubMed

Show entries

Title	Date	PubMed
Pharmacokinetic mechanisms associated with synergism by DEF of cypermethrin toxicity in larval and adult Helicoverpa zea, Spodoptera frugiperda, and Agrotis ipsilon (Lepidoptera: Noctuidae).	2001 Aug	11561846
Toxicity of pyrethroids and effect of synergists to larval and adult Helicoverpa zea, Spodoptera frugiperda, and Agrotis ipsilon (Lepidoptera: Noctuidae).	2001 Aug	11561845
Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides.	2001 May 15	11350214
Effects of the synergists piperonyl butoxide and S,S,S-tributyl phosphorotrithioate on propoxur pharmacokinetics in Blattella germanica (Blattodea: Blattellidae).	2001 Oct	11681686
High level methoprene resistance in the mosquito Ochlerotatus nigromaculis (Ludlow) in central California.	2002 Aug	12192903

Showing 1 to 5 of 37 entries

Previous1 2 3 4 5…8Next

Patents

Sample Use Guides

In Vivo Use Guide

Mice: Tribufos inhibits CB1 in vivo, without cholinergic poisoning signs, by 50% at 50 mg/kg intraperitoneally with a recovery half-time of 3-4 days.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Tribufos inhibited mouse liver FAAH with IC 50 value of 52 uM.

Substance Class	Chemical
Record UNII	53075G8GRF
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

FOSFALL

Preferred Name

English

TRIBUFOS

Common Name

English

B 1,776

Code

English

BUTYL PHOSPHOROTRITHIOATE

Systematic Name

English

S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE

Systematic Name

English

Showing 1 to 5 of 16 entries

Previous1 2 3 4Next

Show entries

Classification Tree

Code System

Code

EPA PESTICIDE

EPA PESTICIDE CODE

74801

Showing 1 to 1 of 1 entries

Previous1Next

Show entries

Code System

Code

Type

Description

MESH

C006863

PRIMARY

MERCK INDEX

m11049

PRIMARY

Merck Index

CHEBI

38737

PRIMARY

ECHA (EC/EINECS)

201-120-8

PRIMARY

EPA CompTox

DTXSID1024174

PRIMARY

Showing 1 to 5 of 10 entries

Previous1 2Next