U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 15:08:59 GMT 2023
Edited
by admin
on Sat Dec 16 15:08:59 GMT 2023
Source Materials Class ORGANISM
Source Materials Type RECOMBINANT VIRUS
Source Materials State LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family Parvoviridae
Organism Genus Dependovirus
Organism Species adeno-associated virus
Author NONE
Infraspecific Type SUBSTRAIN
Infraspecific Name rAAV Rep2-Cap6/ expressing a cDNA that targets 468-485 bp of the albumin locus fused to the obligate heterodimeric FokI nuclease domainELD, under the control of an apolipoprotein E hepatic control region and human alpha-1-antitrypsin promoter (ApoE/hAAT)
Part WHOLE
Record UNII
52XT2AZD2N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RANUZIFIGENE CIVAPARVOVEC
INN  
Official Name English
A RECOMBINANT NON-REPLICATING ADENO-ASSOCIATED VIRUS TYPE 2/6 (RAAV REP2-CAP6) VECTOR, EXPRESSING A CDNA THAT TARGETS 468-485 BP OF THE ALBUMIN LOCUS (RELATIVE TO THE TRANSCRIPTION INITIATION SITE), FUSED TO THE OBLIGATE HETERODIMERIC FOKI NUCLEASE DOMAI
Systematic Name English
ranuzifigene civaparvovec [INN]
Common Name English
Code System Code Type Description
NCI_THESAURUS
C171801
Created by admin on Sat Dec 16 15:08:59 GMT 2023 , Edited by admin on Sat Dec 16 15:08:59 GMT 2023
PRIMARY
FDA UNII
52XT2AZD2N
Created by admin on Sat Dec 16 15:08:59 GMT 2023 , Edited by admin on Sat Dec 16 15:08:59 GMT 2023
PRIMARY
INN
10980
Created by admin on Sat Dec 16 15:08:59 GMT 2023 , Edited by admin on Sat Dec 16 15:08:59 GMT 2023
PRIMARY
CAS
2143578-32-7
Created by admin on Sat Dec 16 15:08:59 GMT 2023 , Edited by admin on Sat Dec 16 15:08:59 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
INSERTED GENE EXPRESSION VECTOR RANUZIFIGENE CIVAPARVOVEC TRANSGENE INSERT 07GL25B550