Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H3Cl7 |
| Molecular Weight | 395.323 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC(Cl)=C(C=C1Cl)C2=C(Cl)C(Cl)=C(Cl)C(Cl)=C2
InChI
InChIKey=WBHQEUPUMONIKF-UHFFFAOYSA-N
InChI=1S/C12H3Cl7/c13-6-3-8(15)7(14)1-4(6)5-2-9(16)11(18)12(19)10(5)17/h1-3H
| Molecular Formula | C12H3Cl7 |
| Molecular Weight | 395.323 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Hydroxyl metabolite of PCB 180 induces DNA damage signaling and enhances the DNA damaging effect of benzo[a]pyrene. | 2015-09-05 |
|
| Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. | 2015-09 |
|
| Polychlorinated Biphenyls (PCB 101, 153, and 180) Impair Murine Macrophage Responsiveness to Lipopolysaccharide: Involvement of NF-κB Pathway. | 2015-09 |
|
| Non-dioxin-like polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) induce chondrocyte cell death through multiple pathways. | 2015-04-02 |
|
| Lactational exposure to low levels of the six indicator non-dioxin-like polychlorinated biphenyls induces DNA damage and repression of neuronal activity, in juvenile male mice. | 2015-02-03 |
|
| Polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) alter leptin signaling and lipid metabolism in differentiated 3T3-L1 adipocytes. | 2014-09-15 |
|
| Correlation of gene expression and contaminant concentrations in wild largescale suckers: a field-based study. | 2014-06-15 |
|
| Dopamine-dependent behavior in adult rats after perinatal exposure to purity-controlled polychlorinated biphenyl congeners (PCB52 and PCB180). | 2014-01-03 |
|
| Role of the nuclear xenobiotic receptors CAR and PXR in induction of cytochromes P450 by non-dioxinlike polychlorinated biphenyls in cultured rat hepatocytes. | 2013-10-01 |
|
| Sexually dimorphic behavior after developmental exposure to characterize endocrine-mediated effects of different non-dioxin-like PCBs in rats. | 2013-09-06 |
|
| Perinatal exposure to purity-controlled polychlorinated biphenyl 52, 138, or 180 alters toxicogenomic profiles in peripheral blood of rats after 4 months. | 2013-08-19 |
|
| Neurodevelopmental and behavioral toxicity via lactational exposure to the sum of six indicator non-dioxin-like-polychlorinated biphenyls (∑6 NDL-PCBs) in mice. | 2012-09-04 |
|
| Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner. | 2012-08-15 |
|
| Association of serum levels of polychlorinated biphenyls with IL-8 mRNA expression in blood samples from asthmatic and non-asthmatic Japanese children. | 2012-06 |
|
| Non-dioxin-like polychlorinated biphenyls interfere with neuronal differentiation of embryonic neural stem cells. | 2011-11 |
|
| Some OH-PCBs are more potent inhibitors of aromatase activity and (anti-) glucocorticoids than non-dioxin like (NDL)-PCBs and MeSO₂-PCBs. | 2011-10-10 |
|
| Transcriptomics identifies differences between ultrapure non-dioxin-like polychlorinated biphenyls (PCBs) and dioxin-like PCB126 in cultured peripheral blood mononuclear cells. | 2011-09-05 |
|
| In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes. | 2011-09 |
|
| Auditory effects of developmental exposure to purity-controlled polychlorinated biphenyls (PCB52 and PCB180) in rats. | 2011-07 |
|
| Hepatic effects of a highly purified 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in male and female rats. | 2011-06-18 |
|
| In vitro toxicity profiling of ultrapure non-dioxin-like polychlorinated biphenyl congeners and their relative toxic contribution to PCB mixtures in humans. | 2011-05 |
|
| Effects of non-dioxin-like polychlorinated biphenyl congeners (PCB 101, PCB 153 and PCB 180) alone or mixed on J774A.1 macrophage cell line: modification of apoptotic pathway. | 2011-04-10 |
|
| Prenatal PCBs disrupt early neuroendocrine development of the rat hypothalamus. | 2011-04-01 |
|
| Endocrine disruption of brain sexual differentiation by developmental PCB exposure. | 2011-02 |
|
| In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. | 2011-01 |
|
| Activation and potentiation of human GABAA receptors by non-dioxin-like PCBs depends on chlorination pattern. | 2010-11 |
|
| Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms. | 2010-04-19 |
|
| Determination of organochlorine pesticide and polychlorinated biphenyl levels in adipose tissue of infertile men. | 2010-03 |
|
| Evaluation of an hPXR reporter gene assay for the detection of aquatic emerging pollutants: screening of chemicals and application to water samples. | 2010-01 |
|
| Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells. | 2009-12-10 |
|
| Transactivation potencies of Baikal seal constitutive active/androstane receptor by persistent organic pollutants and brominated flame retardants. | 2009-08-15 |
|
| Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat Part 2: Effects on reproductive parameters, on sex behavior, on memory retention and on hypothalamic expression of aromatase and 5alpha-reductases in the offspring. | 2009-08-15 |
|
| Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat: Part 1: Effects on somatic growth, growth hormone-axis activity and bone mass in the offspring. | 2009-06-01 |
|
| A physiologically based pharmacokinetic model for the assessment of infant exposure to persistent organic pollutants in epidemiologic studies. | 2009-03 |
|
| Association of organochlorine pesticides with peripheral neuropathy in patients with diabetes or impaired fasting glucose. | 2008-11 |
|
| Polychlorinated biphenyl exposure and neuropsychological status among older residents of upper Hudson River communities. | 2008-02 |
|
| Dioxin-like compound load in bulk of Chlorofen--a technical chlorobiphenyl formulation from Poland. | 2007-11 |
|
| Constitutive androstane receptor (CAR) as a potential sensing biomarker of persistent organic pollutants (POPs) in aquatic mammal: molecular characterization, expression level, and ligand profiling in Baikal seal (Pusa sibirica). | 2006-11 |
|
| PCB exposure and in vivo CYP1A2 activity among Native Americans. | 2005-03 |
|
| Retention indexes for temperature-programmed gas chromatography of polychlorinated biphenyls. | 2004-09-15 |
|
| Lineage-specific effects of polychlorinated biphenyls (PCB) on gene expression in the rabbit blastocyst. | 2004-04-08 |
|
| Assessment of xenoestrogenic exposure by a biomarker approach: application of the E-Screen bioassay to determine estrogenic response of serum extracts. | 2003-10-15 |
|
| Inhibition of E2-induced expression of BRCA1 by persistent organochlorines. | 2002 |
|
| Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity. | 2001-02-14 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:52:28 GMT 2025
by
admin
on
Mon Mar 31 21:52:28 GMT 2025
|
| Record UNII |
52I0CG8IQX
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| Record Status |
Validated (UNII)
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| Record Version |
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35065-29-3
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37036
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52I0CG8IQX
Created by
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